A5039398407- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Cerebrospinal fluid and hydrocephalus
- Restless Legs Syndrome Research
- Head and Neck Surgical Oncology
- Histone Deacetylase Inhibitors Research
- Ultrasound and Hyperthermia Applications
- Parkinson's Disease and Spinal Disorders
- Epilepsy research and treatment
- Peripheral Artery Disease Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects and Toxicity Studies
- Venous Thromboembolism Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Sinusitis and nasal conditions
- MRI in cancer diagnosis
- ATP Synthase and ATPases Research
- Parkinson's Disease Mechanisms and Treatments
- Cancer Mechanisms and Therapy
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014-2024
Universitätsklinikum Erlangen
2014-2024
Abstract Acute ischemic stroke (AIS) is a leading global cause of mortality and morbidity. Improving long-term outcome predictions after thrombectomy can enhance treatment quality by supporting clinical decision-making. With the advent interpretable deep learning methods in recent years, it now possible to develop trustworthy, high-performing prediction models. This study introduces an uncertainty-aware, graph model that predicts endovascular outcomes using features imaging biomarkers. The...
General guideline recommendations in patients with intracerebral hemorrhage (ICH) include blood pressure-, temperature- and glucose management. The therapeutic effect of such a "care bundle" (blood pressure lowering, glycemic control, treatment pyrexia) on clinical outcomes becomes increasingly established. For the present study, we aimed to investigate associations strict bundled care (BCT) characterize key outcome effectors as hematoma enlargement (HE) peak perihemorrhagic edema (PHE).
Malignant gliomas can be counted to the most devastating tumors in humans. Novel therapies do not achieve significant prolonged survival rates. The cancer cells have an impact on surrounding vital tissue and form tumor zones, which make up microenvironment. We investigated effects of sunitinib, a small molecule multitargeted receptor tyrosine kinase inhibitor, constituents microenvironment such as gliomas, astrocytes, endothelial cells, neurons. Sunitinib has known anti-angiogenic effect....
Several automated computed tomography perfusion software applications have been developed to provide support in the definition of ischemic core and penumbra acute stroke. However, degree interchangeability between packages is not yet clear. Our study aimed evaluate 2 commonly used (Syngo.via RAPID) for indication with respect follow-up infarct volume (FIV) after successful recanalization consideration clinical impact.Retrospectively, 154 patients large vessel occlusion middle cerebral artery...
Primary brain tumors are hallmarked for their destructive activity on the microenvironment and vasculature. However, solely few experimental techniques exist to access tumor under anatomical intact conditions with remaining cellular extracellular composition. Here, we detail an ex vivo vascular glioma impact method (VOGIM) investigate influence of gliomas chemotherapeutics angiogenesis that closely resemble in situation. We generated organotypic slice cultures from rats transgenic mice...
Objective Hematoma expansion (HE) is the most important therapeutic target during acute care of patients with intracerebral hemorrhage (ICH). Imaging biomarkers such as non-contrast CT (NCCT) markers have been associated increasing risk for HE. The aim present study was to evaluate influence NCCT functional long-term outcome and HE in deep (basal ganglia thalamus) ICH who represent an subgroup at highest deterioration due eloquence affected brain region. Methods From our prospective...
// Zheng Fan 1, * , Philipp Bittermann-Rummel Eduard Yakubov 2 Daishi Chen 1 Thomas Broggini 3 Tina Sehm Gökce Hatipoglu Majernik Stefan W. Hock Marc Schwarz 4 Tobias Engelhorn Arnd Doerfler Michael Buchfelder Ilker Y. Eyupoglu # Nicolai E. Savaskan 5, Translational Neurooncology Laboratory, Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander Erlangen-Nürnberg (FAU), Germany Klinikum Nürnberg, Paracelsus Medical University, Charité - Universitätsmedizin Berlin,...
Background: Innovative automated perfusion software solutions offer support in the management of acute stroke by providing information about infarct core and penumbra. While performance different has mainly been investigated patients with successful recanalization, prognostic accuracy hypoperfusion maps cases futile recanalization hardly validated. Methods: In 39 ischemic (AIS) due to large vessel occlusion (LVO) anterior circulation poor revascularization (thrombolysis cerebral infarction...
Hippocampal-sparing radiotherapy (HSR) is a promising approach to alleviate cognitive side effects following cranial radiotherapy. Microstructural brain changes after irradiation have been demonstrated using Diffusion Tensor Imaging (DTI). However, evidence conflicting for certain parameters and anatomic structures. This study examines the of radiation on white matter hippocampal microstructure DTI evaluates whether these may be mitigated HSR. A total 35 tumor patients undergoing prospective...
<h3>Importance</h3> It is uncertain whether thrombectomy associated with benefits in patients prestroke disability. <h3>Objective</h3> To evaluate the use of for large vessel occlusion and <h3>Design, Setting, Participants</h3> This cohort study included stroke disability (modified Rankin Scale score, 3 or 4) admitted to a single tertiary care center between January 1, 2006, June 30, 2019 (controls: 2006-2015; thrombectomy: 2015-2019). Follow-up was conducted at 90 days. Data analysis...
Abstract Background Abrupt visual impairment constitutes a medical urgency, necessitating an interdisciplinary diagnostic and therapeutic approach owing to the broad spectrum of potential etiologies, thereby engaging numerous specialties. Case presentation A 21-year-old Mixed White Asian female patient, with history nonsteroidal antiinflammatory drug-exacerbated respiratory disease previous sinus surgery, reported sudden monocular vision loss. Unremarkable ophthalmological examination fellow...
Abstract Aim The aim of this study was to re‐evaluate risk factors for post‐ICH epilepsy (PICHE) and examine the impact surgical hematoma evacuation on development after ICH. Background purpose Epilepsy is a common complication intracerebral hemorrhage (ICH). Information still scarce role ICH remains uncertain. Methods We retrospectively included patients with spontaneous treated in our hospital 2006–2019. Patients' medical records were analyzed. In addition, mailed questionnaires telephone...
Restless legs syndrome (RLS) is known to be associated with multiple sclerosis (MS) and may caused by MS lesions in specific cerebral brain regions. Applying a voxel-wise lesion analysis, we tried identify the contribution of RLS.In this retrospective study, established cohort people documented RLS controls without matched disease severity. Diagnosis was based on current guidelines. The were analyzed T2-weighted magnetic resonance imaging scans (1.5 or 3 T). After manual delineation, maps...
Purpose Treating cerebral dural arteriovenous fistulas (dAVFs) by transarterial embolization is an established endovascular approach but no data exist regarding the utility of using newly introduced microcatheters with extra-long detachable tip. Aim our study was to evaluate value these and, additionally, combining them simplified pressure cooker technique. Methods Twenty-nine patients treated for dAVF were enrolled. In a subgroup fifteen technique additionally applied. Demographics and...
Background: Hyperdense lesions in CT after EVT of LVO are common. These predictors for haemorrhages and an equivalent the final infarct. The aim this study based on FDCT was evaluation predisposing factors these lesions. Methods: Using a local database, 474 patients with mTICI ≥ 2B were recruited retrospectively. A postinterventional recanalisation analysed regarding such hyperdense This correlated variety items (demographics, past medical history, stroke assessment/treatment...
Differentiation of active multiple sclerosis lesions from non-active ones is done in the clinical environment by using contrast enhanced T1 images. CEST MRI has shown to yield correlations with Gadolinium enhancement tumors and other pathological tissue. In this work, we are trying gain more insight metabolic information regarding brain patients suffering sclerosis.