A5064152945- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Olfactory and Sensory Function Studies
- Epilepsy research and treatment
- Biochemical Analysis and Sensing Techniques
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Neonatal and fetal brain pathology
- Genetic Neurodegenerative Diseases
- Sepsis Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Bacterial Infections and Vaccines
- Cardiac Health and Mental Health
- Dementia and Cognitive Impairment Research
- Cerebrospinal fluid and hydrocephalus
- Stroke Rehabilitation and Recovery
- Functional Brain Connectivity Studies
- Dysphagia Assessment and Management
- Gut microbiota and health
- Multisensory perception and integration
- Multiple Sclerosis Research Studies
- Atrial Fibrillation Management and Outcomes
Universitätsklinikum Erlangen
2015-2025
Justus-Liebig-Universität Gießen
2024-2025
Universitätsklinikum Gießen und Marburg
2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
XinHua Hospital
2022
Intracerebral hemorrhage (ICH) contributes significantly to the global burden of disease.
In patients with lobar intracerebral hemorrhage (ICH), etiologic characterization represents a tradeoff between feasibility, resource allocation, and diagnostic certainty. This study investigated the accuracy clinical utility of simplified Edinburgh CT criteria to identify underlying cerebral amyloid angiopathy (CAA).This external validation analyzed 210 consecutive ICH available MRI studies from prospective single-center observational cohort (2006-2015, Longitudinal Cohort Study on Care...
Integrating cerebrospinal fluid-biomarkers into diagnostic workup of patients with sporadic cerebral amyloid angiopathy may support early and correct identification. We aimed to identify validate clinical- for in vivo diagnosis angiopathy. This observational cohort study screened 2795 consecutive admitted cognitive complaints the academic departments neurology psychiatry over a 10-year period (2009-2018). included 372 available hemosiderin-sensitive MR imaging fluid-based neurochemical...
Background: Severe strokes often require deep sedation, yet the optimal sedation regimen remains unclear. This comparative study compared efficacy of achieving target depth using inhaled (isoflurane) versus intravenous (propofol) sedation. Methods: prospective, observational, proof-of-concept was conducted between July 2022 and June 2023 at two University Hospitals with dedicated neurological intensive care units. We included conservatively treated patients severe space-occupying (ischemic...
Abstract Headache is very frequent in multiple sclerosis. However, the question whether headache just coincidental or may be secondary due to inflammatory cerebral sclerosis lesions yet clarified. This study intended evaluate distribution of lesion sites and potential presence specific clusters patients with comorbid using voxel-based symptom mapping (VLSM). Patients were prospectively identified included a university neurological center between 2017 2023. Only onset after first...
ABSTRACT Objective Increasing evidence shows that patients with intracerebral hemorrhage (ICH) can achieve better‐than‐expected outcomes aggressive therapy. However, real‐world long‐term data, patient‐centered outcomes, and societal measures after maximal ICH treatment are lacking. This study aimed to analyze 5‐year survival, utility‐weighted functional burden of disease in maximally treated patients, stratified by max‐ICH Score. Methods investigated consecutive spontaneous included the...
General guideline recommendations in patients with intracerebral hemorrhage (ICH) include blood pressure-, temperature- and glucose management. The therapeutic effect of such a "care bundle" (blood pressure lowering, glycemic control, treatment pyrexia) on clinical outcomes becomes increasingly established. For the present study, we aimed to investigate associations strict bundled care (BCT) characterize key outcome effectors as hematoma enlargement (HE) peak perihemorrhagic edema (PHE).
Altered gut microbiota may trigger or accelerate alpha-synuclein aggregation in the enteric nervous system Parkinson's disease (PD). While several previous studies observed alterations PD, findings like diversity indices, and altered bacterial taxa itself show a considerable heterogeneity across studies. We recruited 179 participants, of whom 101 fulfilled stringent inclusion criteria. Subsequently, composition 71 PD patients 30 healthy controls was analyzed, sequencing V3-V4 regions 16S...
The impact of platelets on hematoma enlargement (HE) intracerebral hemorrhage (ICH) is not yet sufficiently elucidated. Especially the role reduced platelet counts HE and clinical outcomes still poorly understood. This study investigated influence thrombocytopenia HE, functional outcome, mortality in patients with ICH or without prior antiplatelet therapy (APT).Individual participant data multicenter cohort studies (multicenter RETRACE program [German-Wide Multicenter Analysis Oral...
For outcome assessment in patients surviving subarachnoid hemorrhage (SAH), the modified Rankin scale (mRS) represents mostly established tool, whereas other dimensions of such as mood disorders and impairments social life remain unattended so far.The aim our study was to correlate 12-month functional subjective health outcomes SAH survivors.All treated over a 5-year period received at 12 months, including scores (mRS Barthel Index [BI]), measurement (EQ-5D), whether they returned work....
Based on artificial intelligence (AI), 3D angiography (3DA) is a novel postprocessing algorithm for "DSA-like" imaging of cerebral vasculature. Because 3DA requires neither mask runs nor digital subtraction as the current standard 3D-DSA does, it has potential to cut patient dose by 50%. The object was evaluate 3DA's diagnostic value visualization intracranial artery stenoses (IAS) compared 3D-DSA.3D-DSA datasets IAS (nIAS = 10) were postprocessed using conventional and prototype software...
Objective Hematoma expansion (HE) is the most important therapeutic target during acute care of patients with intracerebral hemorrhage (ICH). Imaging biomarkers such as non-contrast CT (NCCT) markers have been associated increasing risk for HE. The aim present study was to evaluate influence NCCT functional long-term outcome and HE in deep (basal ganglia thalamus) ICH who represent an subgroup at highest deterioration due eloquence affected brain region. Methods From our prospective...
Abstract The role of neuroinflammation in the pathophysiology seizures is increasingly recognized, and evaluation potential biochemical markers inflammatory processes status epilepticus (SE), such as C‐reactive protein (CRP), has gained attention. present study assessed first CRP level obtained an SE episode regarding its value for outcome prediction. Among 362 admissions during period, 231 episodes satisfied inclusion criteria. Higher initial concentrations were independently associated...
There is growing interest in non-motor symptoms Parkinson's disease (PD), due to the impact on quality of life. Anhedonia, inability experience joy and lust, has a prevalence up 46% PD. The perception pleasantness an odor reduced anhedonia without We previously showed hedonic olfactory PD, i.e., patients evaluated odors as less pleasant or unpleasant compared controls. This deficit correlated with anhedonia.We aimed confirm these findings. Moreover, we hypothesized that PD affected...
Data regarding the influence of concomitant parenchymatous hematoma (PH) on long-term outcomes in patients with atraumatic subarachnoid hemorrhage (SAH) are scarce. Further, it is not established if these benefit from surgical intervention.The aim this study was to determine PH SAH functional outcome, and whether may evacuation.Over a 5-year period, all consecutive treated at Departments Neurology, Neuroradiology, Neurosurgery, University Hospital Erlangen (Germany) were recorded. In...
Abstract In community-acquired bacterial meningitis (CABM) intracranial vascular alterations are devastating complications which triggered by neuroinflammation and result in worse clinical outcome. The Neutrophil-to-Lymphocyte ratio (NLR) represents a reliable parameter of the inflammatory response. this study we analyzed association between NLR elevated cerebral blood flow velocity (CBFv) CABM-patients. This included all (CABM)-patients admitted to German tertiary center 2006 2016....
Cervical artery dissection (CAD) is a relevant etiology of transient ischemic attacks and strokes. Several trials explored the significance specific antithrombotic treatments, i.e. oral anticoagulation (OAC) versus antiplatelet treatment (APT), on recurrent complications clinical outcomes. As overall incidence rates were low there still controversy which should be used. However, up to now has been no systematic investigation among CAD-patients with stroke specifically comparing course...
Introduction: Neurocritical care patients with neurovascular disease often face poor long-term outcomes, highlighting the pivotal role of evidence-based interventions. Although International Guidelines emphasize managing basic physiological parameters like temperature, blood glucose, pressure, and oxygen levels, physician adherence to these targets remains uncertain. This study aimed assess guideline-based treatment for in neurocritical care. Patients Methods: multicenter observational was...
Sarcoidosis is a granulomatous disease of unknown etiology affecting the central nervous system in up to 15% patients. Diagnosis neurosarcoidosis very challenging due heterogeneity its clinical manifestation. This study intended evaluate distribution cerebral lesion sites and potential presence specific clusters patients using voxel-based symptom mapping (VLSM).Patients with were retrospectively identified included between 2011 2022. Cerebral correlated voxel-wise absence non-parametric...
Predicting final stent position can be challenging when treating cerebral aneurysms. Third-Party software proved helpful in selecting proper stents treatment planning. Recent angiographic systems provide basic simulation capabilities integrated the post-processing to simulate position. Goal of this analysis was evaluate process and correlation with definite position.Thirty-three datasets fusiform (n = 10) saccular 23) aneurysms, treated or flow-diverter, were processed. A "virtual stent"...