Introduction Alzheimer’s disease (AD), the most prevalent type of dementia among older individuals, is characterized by severe neurodegeneration with symptoms progressive loss cognitive capacity. We aimed to investigate effects curcumin (Curc) and Inula viscosa (IV) plant extracts on apoptosis oxidative stress in an amyloid-β (Aβ<i></i>)-induced vitro AD model. Material methods The human glioblastoma cell line (U87) was treated Aβ produce Treatment groups were: + Curc, IV, IV...

Plants provide a wealth of bioactive compounds which aid in exerting substantial strategy for the treatment neurological disorders such as Alzheimer's disease and dementia.

One of the prominent health problems caused by Aluminium was decrease in male fertility rates. In study, protective effect Esculetin (ESC) against reproductive toxicity induced chloride (AlCl3) investigated. For this purpose, AlCl3 administrated to Wistar Albino rats at a dose 34 mg/kg and ESC 50 for 70 days. It determined that treatment reduced sperm motility concentration, increased dead/live rate abnormal rate. decreased serum testosterone level, co-treatment significantly regulated these...

Background: Renal tubular cells are exposed to high toxin concentrations more than other tissues because of active secretion, reabsorption and urine concentration mechanisms in kidneys.Due this reason, renal tubules direct targets nephrotoxicity.Alphalinolenic acid is a carboxylic acid, whose anti-inflammatory anti-oxidant effects shown various studies.Because this, study examine the protective alpha-linolenic on nephrotoxicity planned.Materials Methods: Gentamicin administered mice for 9...

Background and Objective: Hypericum perforatum is a plant which blooms between July September at farms, borders of roads woods, top hills grasslands, whose anti-inflammatory effects are shown in various studies.Due to this reason, study planned examine the protective on nephrotoxicity caused by gentamicin.Materials Methods: Gentamicin administered mice for 9 days form extract evaluate effects.Cyclooxygenase-2, phospholipase A2 inducible nitric oxide synthase enzymes their kidneys analysed...

Summary Iron overload is a serious clinical condition for humans and key target in drug development. The aim of this study was to investigate the coordination iron(III) ions with curcumin ligand that may be used treatment iron overload. Iron(III) complex synthesized structurally characterized its solid solution state by FT‐IR, UV‐Vis, elemental analysis, magnetic susceptibility. Electrochemical behaviour complexes were examined using cyclic voltammetry. cytotoxic activities evaluated MTT...

To determine how daylight exposure in mice affects melatonin protein expression blood and Kiss1 gene the hypothalamus. The second aim was to assess relationship between skin cancer formation, exposure, level, kisspeptin level.New-born (n=96) were assigned into blind group or group. raised dark under 12 hours light/12 cycle for 17 weeks. At end of 11th week, melanoma cell line inoculated mice, tumor growth observed 6 experiment, level measured from serum hypothalamus.The had significantly...

Abstract Iron overload is a key target in drug development. This study aimed to investigate the coordination of Fe(III) ions with curcumin‐oxime ligand that may be used treatment iron overload. The synthesis and curcumin‐oxime‐Fe(III) complex was successfully made characterized its solid‐state solution‐state using FT‐IR, UV‐Vis, elemental analysis, 1 H‐NMR. However, this study, we investigated apoptotic effects Fe (III) on SW480. SW480 cells were exposed 99.2% medium for 48 hours. After...

BACKGROUND: Thymoquinone (TQ) is the active compound extracted from Nigella sativa which has been reported to possess various pharmacological attributes.This study shows that an Alzheimer's disease (AD) model cell line on amyloid-beta (Aβ) -induced U87 (human astrocytoma line) in β-amyloid (Aβ)-induced vitro Disease model.AIM: We aimed investigate effects antioxidant and apoptotic pathways.METHODS: In three groups were formed, control group, Aβ + TQ group obtained by adding group.Firstly,...

Background: Iron overload, common in patients with hematological disorders, is a key target drug development. This study investigated the effects of curcumin on iron overload rats.
 Methods: Forty male Wistar rats weighing 139.78 ± 11.95 gm (Mean SD) were divided into three equal groups: (i) controls; (ii) group that received six doses dextran 1000 mg/kg–1 by intraperitoneal injections (i.p.); and (iii) (1000 mg/kg BW i.p.). In addition to i.p., we studied liver function enzymes...

Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose this study was to if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects.Depression-like were investigated an unpredictable chronic mild stress (UCMS) model male female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on floor predator sounds used induce light at different times for six weeks. Dipyrone...

Purpose: The study aims to investigate the effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) administered subacute period neuropathic mice on allodynia and nerve-muscle tissue functions during 24 weeks. Materials Methods: Peripheral neuropathy was induced by partial sciatic nerve ligation. Experiments were conducted in Control, Sham, Neuropathic, BM-MSC, Neuropathic+BM-MSC groups. Allodynia measured cold plate test at 2nd, 6th, 24th Electrophysiological histopathological...

<title>Abstract</title> OBJECTIVES This study investigated the effects of berberine and baicalin, both individually in combination, on cell proliferation apoptosis PC-3 prostate cancer cells. cells were treated with different concentrations berberine, baicalin or their MATERIALS AND METHODS The these treatments viability assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Enzyme-linked immunosorbent (ELISAs) assays also used to measure levels...

Background and Objective: Hypericum perforatum (HP) is known to have therapeutic effects in many types of cancer.Although the active substances hypericin hyperforin composition HP been shown exert apoptotic cancer cell lines, research into anticancer total extract meagre.The aim this study was investigate proapoptotic effect on human colorectal adenocarcinoma line HT29.Materials Methods: HT29 cells (5×10 4 cmG 2 ) were exposed 99.2% medium pharmacologically effective concentration (0.8%) for...

urpose: The aim of this study was to investigate the cytotoxicity effect, iron chelator and antioxidant activities (III) ions with curcumin ligand that may be used in treatment overload. Materials Methods: cytotoxic complex were evaluated by MTT assay. SOD activity determined using its ability inhibit reduction NBT. catalytic studies Fe(III) DMSO towards disproportionation hydrogen peroxide also performed.Results: IC50 values are found 6.8 μM catalase measured. Where at a concentration 2.0...

Purpose: The aim of this study was to investigate the effects Inula viscosa extract and Curcumin on U87 (human astrocytoma cell line) treated with amyloid-beta (Aβ), which is Alzheimer’s disease (AD) model line.&#x0D; Materials Methods: Firstly, cytotoxic potential ınula curcumin investigated in cells by colorimetric MTT (3-4,5-dimethyl-thiazolyl-2,5-diphenyltetrazolium bromide) assay. Then, amount Total Glutathione, Malondialdehyde (MDA), Glutathione reductase (GR) activities were...

Background: An analgesic-antipyretic drug dipyrone shows its effects via central prostaglandin system, opiatergic and cannabinoid systems, cytokine levels, TRP channels descending serotonergic-noradrenergic pathways. The functional roles of all these mechanisms have been established also in mood disorders. It is known that pain depression are frequently seen together. In the light information we aimed to investigate whether has an antidepressant-like effect.

Purpose: The anti-inflammatory and antioxidant properties of D-pantothenic acid have been demonstrated the effects dexpentanol on inflammatory pathways apopototic that trigger cell death are interest. Apoptotic important in resistance to chemotherapeutics cancer diseases development. Therefore, we planned how treatment PC-3 human prostate cells with dexpanthenol will affect levels activities apoptotic inflammation mediators. For this purpose, culture was performed.&#x0D; Materials Methods:...