A5013080076- Pancreatic function and diabetes
- Birth, Development, and Health
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
- Metabolism, Diabetes, and Cancer
- Stress Responses and Cortisol
- Gut microbiota and health
- Paraoxonase enzyme and polymorphisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Clostridium difficile and Clostridium perfringens research
- Lipoproteins and Cardiovascular Health
- Blood properties and coagulation
- Extracellular vesicles in disease
- Fatty Acid Research and Health
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
Rzeszów University
2025
Jagiellonian University
2014-2023
Collegium Medicum in Bydgoszcz
2020
John Paul II Hospital
2017-2019
Institute of Cardiology
2017
British Heart Foundation
2016
University of Glasgow
2016
Joslin Diabetes Center
2003-2012
Harvard University
2003-2012
University School of Physical Education in Kraków
2009-2012
OBJECTIVE Despite extensive evidence for genetic susceptibility to diabetic nephropathy, the identification of genes and their variants has had limited success. To search that contribute a genome-wide association scan was implemented on Genetics Kidneys in Diabetes collection. RESEARCH DESIGN AND METHODS We genotyped ∼360,000 single nucleotide polymorphisms (SNPs) 820 case subjects (284 with proteinuria 536 end-stage renal disease) 885 control type 1 diabetes. Confirmation implicated SNPs...
Progressive renal function decline begins in one third of patients with microalbuminuria and type 1 diabetes. This study examined whether this is associated elevated excretion inflammatory markers urine. Five (IL-6, IL-8, monocyte chemoattractant protein-1, interferon-gamma-inducible protein (IP-10), macrophage protein-1delta) were measured urine samples from the First Joslin Study Natural History Microalbuminuria Type Diabetes, a cohort recruited 1991. Samples obtained 43 participants...
Blood is considered to be a sterile microenvironment, in which bacteria appear only periodically. Previously used methods allowed for the detection of either viable with low sensitivity or selected species bacteria. The Next-Generation Sequencing method (NGS) enables identification all sample their taxonomic classification. We NGS analysis blood samples from healthy volunteers (n = 23) and patients sepsis 62) check whether any bacterial DNA exists people identify profile septic patients....
Abstract The aetiology of inflammatory bowel diseases (IBD) seems to be strongly connected changes in the enteral microbiome. dysbiosis pattern seen Crohn’s disease (CD) differs among published studies depending on patients’ age, phenotype and microbiome research methods. aims was investigate treatment-naive paediatric patients get an insight into its structure at early stage comparison healthy. Stool samples were obtained from controls newly diagnosed prior any intervention. Microbiota...
Introduction Scientific data indicate a possible influence of gut microbiota on the development type 1 and 2 diabetes mellitus (T1DM T2DM, respectively). Sequence analysis 16S ribosomal RNA identified several hundred bacterial species intestinal ecosystem, most which cannot be cultured. Objectives We aimed to evaluate composition in adult patients with T1DM T2DM establish link between microbiological test results patients' clinical data. Patients methods examined DNA isolated from fecal...
Decreased plasma levels of microRNA-223 (miR-223), predominantly platelet origin, were proposed as a surrogate marker efficacy antiplatelet therapy. However, higher on-treatment reactivity was associated with lower miR-223 in patients coronary artery disease (CAD) on dual therapy (DAPT) including clopidogrel and aspirin. Our aim to compare CAD DAPT newer P2Y12 antagonists vs. clopidogrel. We studied 21 men admitted our centre owing non-ST-elevation acute syndrome, an uncomplicated hospital...
The human paraoxonase (PON) gene family consists of three members, PON1, PON2, and PON3, located adjacent to each other on chromosome 7. PON catalytic activity may be influenced by frequent amino acid variants. Chronic exposure certain chemicals or environmental factors causing enhanced lipid peroxidation metabolized paraoxonases a risk factor for sporadic ALS (sALS).The aim this study was examine the association between PON1 Q192R, L55M, PON2 C311S functional polymorphisms sALS in Polish...
Background and Purpose— Formation of denser fiber networks has been reported in atrial fibrillation ischemic stroke. In this longitudinal cohort study, we evaluated whether fibrin clot density may predict thromboembolic bleeding risk patients with on vitamin K antagonists. Methods— 236 receiving antagonists treatment, measured ex vivo plasma permeability (K s ), a measure the pore size networks. Results— During median follow-up 4.3 (interquartile range, 3.7–4.8) years, annual rates stroke or...
The proteomic profile of the human cardiac conduction system: sinoatrial node (SAN) and atrioventricular (AVN), remains poorly understood. aim current study is to identify characteristic SAN AVN in comparison working myocardium right atrium (RAM) ventricle (RVM). analysis was performed on 10 autopsied heart specimens collected from healthy adults. During data-independent acquisition proteomics 2752 different proteins were identified all sample sets. In both nodal tissues (compared...
Decreased availability of nitric oxide (NO), which contributes to the development diabetes vascular complications (1), is partially related asymmetric dimethylarginine (ADMA). ADMA an endogenous NO synthase inhibitor (2) and a competitive cellular l-arginine uptake (3). has been associated with atherosclerosis in nondiabetic populations (4) diabetic nephropathy type 1 (5). In humans, stereoisomer ADMA, symmetric (SDMA), produced equivalent quantities; though it does affect synthesis, SDMA...
Abstract Vascular dysfunction is an important phenomenon in hypertension. We hypothesized that angiotensin II (AngII) affects transcriptome the vasculature a region-specific manner, which may help to identify genes related vascular AngII-induced Mesenteric artery and aortic was profiled using Illumina WG-6v2.0 chip control AngII infused (490 ng/kg/min) hypertensive mice. Gene set enrichment leading edge analyses identified Sphingosine kinase 1 (Sphk1) highest number of pathways affected by...
2][3] Its diagnosis helps understand the pathogenesis of disease, defines risk diabetes within a family, and enables to modify treatment in substantial number patients.
Gastric cancer is the fourth most common cause of cancer-related death. Currently, it broadly accepted that molecular complexity and heterogeneity gastric cancer, both inter- intra-tumor, display important barriers for finding specific biomarkers early detection diagnosis this malignancy. Early-onset not as prevalent conventional carcinoma, but a preferable model studying genetic background, young patients are less exposed to environmental factors, which influence development.The main...
The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. FTO (FTO alpha-ketoglutarate dependent dioxygenase) a gene well-established connection with adiposity, while protooncogene PLAG1 (PLAG1 zinc finger) has been only recently linked to this condition. We performed cross-sectional study on cohort 16 obese (aged 6.6–17.7) 10 healthy 11.4–16.9) children. aim was evaluate the relationship between methylation expression aforementioned genes presence as well...
Chemokines and their receptors have been implicated in the development of diabetic nephropathy. To determine whether risk nephropathy is influenced by two functional polymorphisms regulated upon activation normal T-cell expressed secreted (RANTES) receptor gene (CCR5), we recruited patients with type 1 diabetes, including 496 case subjects overt proteinuria or end-stage renal disease 298 control normoalbuminuria. Male carriers 59029G allele, which associated diminished expression CCR5 on...
Recently, several studies explored associations between type 1 diabetes (T1DM) and microbiota. The aim of our study was to assess the colonic microbiota structure according metabolic control in T1DM patients treated with insulin pumps. We studied 89 (50.6% women) at median age 25 (IQR, 22–29) years. Pielou’s evenness (p = 0.02), Shannon’s 0.04) Simpson’s diversity indexes 0.01), were higher glycosylated hemoglobin (HbA1c) ≥ 53 mmol/mol (7%). There no differences beta groups. A linear...