A5038696851- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Effects of Exercise
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Circular RNAs in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Glutathione Transferases and Polymorphisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Muscle Physiology and Disorders
- Synthesis and Biological Evaluation
- Cardiac Imaging and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Antiplatelet Therapy and Cardiovascular Diseases
- Chemical Synthesis and Analysis
- Coronary Interventions and Diagnostics
- Prostate Cancer Treatment and Research
- Connective tissue disorders research
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- MicroRNA in disease regulation
- Pulmonary Hypertension Research and Treatments
- Stress Responses and Cortisol
Jagiellonian University
2013-2023
John Paul II Hospital
2017-2019
Decreased plasma levels of microRNA-223 (miR-223), predominantly platelet origin, were proposed as a surrogate marker efficacy antiplatelet therapy. However, higher on-treatment reactivity was associated with lower miR-223 in patients coronary artery disease (CAD) on dual therapy (DAPT) including clopidogrel and aspirin. Our aim to compare CAD DAPT newer P2Y12 antagonists vs. clopidogrel. We studied 21 men admitted our centre owing non-ST-elevation acute syndrome, an uncomplicated hospital...
Abstract It is unknown whether fibrosis‐associated micro RNA s: miR‐21, miR‐26, miR‐29, miR‐30 and miR‐133a are linked to cardiovascular ( CV ) outcome. The study evaluated the levels of extracellular matrix ECM fibrosis prevalence particular s in patients with dilated cardiomyopathy DCM investigate any correlation events. Methods: Seventy (48 ± 12 years, EF 24.4 7.4%) underwent right ventricular biopsy. control group was comprised 7 CAD who CABG intraoperative Micro were measured blood...
The tissue renin-angiotensin system (RAS) plays an important role in the development and progression of many diseases. It has been confirmed that angiotensin II (ANG II) participates proliferation angiogenesis breast cancer. Moreover, some RAS dysregulations cancer have observed. Recent studies on two opposite axes angiotensinogen metabolism - ACE (angiotensin-converting enzyme)/ANGII/AT1R (angiotensin receptor type 1) ACE-2/ANG 1-7/MAS (mitochondrial assembly) indicate their importance...
Left ventricular reverse remodeling (LVRR) determines clinical status and outcomes in dilated cardiomyopathy (DCM). The extent of myocardial fibrosis is connected to the systolic function heart. recent discovery contribution microRNAs (miRs) regulation cardiac remodeling, LVRR warrants exploration.The aim study was examine predictive value circulating miR expression for DCM.Seventy consecutive DCM patients (age 48 ±12.1 years, 90% male, ejection fraction (EF) 24.4% ±7.4%) were included...
Abstract Background The use of doxorubicin is associated with an increased risk acute and long-term cardiomyopathy. Despite the constantly growing number cancer survivors, little known about transcriptional mechanisms which progress in time leading to a severe cardiac outcome. It also unclear whether transcriptomic alterations related are similar patterns present patients suffering from other cardiomyopathies. Methods We have sequenced miRNA total plasma extracellular vesicles (EVs) 66...
Background: The relationship between right ventricle (RV), extracellular matrix (ECM) fibrosis and fibrosis-linked, circulating microRNAs in dilated cardiomyopathy (DCM) is unknown. Aim: aim of the study was to uncover associations serum markers ECM metabolism with RV morphological functional parameters. Methods: population consisted 70 consecutive DCM patients (ejection fraction 24.4 ± 7.4%). Based on detailed echocardiographic assessment — 15 had normal RV, whereas 55 dilatation (RVD)...
Urocortin 2 (Ucn2) - corticotropin-releasing hormone receptor signalling has favourable effects in the cardiovascular system, including vasodilation, lowering of blood pressure and systemic peripheral resistance, increase cardiac output contractility, as well cardioprotection against ischemia-reperfusion injury. Vasodilation seem to be very interesting important effects, but their mechanism interaction with antihypertensive drugs have not been evaluated. The aim present study was assess...
A single measurement of any biomarker may not reflect its full biological meaning. The kinetics fibrosis-linked microRNAs and their relationship with extracellular matrix (ECM) fibrosis in dilated cardiomyopathy (DCM) have been explored.We evaluated 70 consecutive DCM patients (48 ±12.1 years, left ventricular ejection fraction 24.4 ±7.4%). All underwent right endomyocardial biopsy order to quantify ECM measure collagen volume (CVF). Circulating (miR-21-5p, miR-29b, miR-30c-5p, miR-133a-3p)...
Fourteen new 2,3-dialkoxyphenazine derivatives with two different alkoxy groups bearing R1 and R2 alkyl chains, defined as −CH2CH(CH3)2 −(CH2)n−1CH3 for n = 1, 2, 4, 6, 8, 10, were prepared via regioselective synthesis. The applied synthetic protocol is based on the following reactions: Buchwald–Hartwig coupling of a nonsymmetrically substituted 4,5-dialkoxy-2-nitroaniline 1-bromo-2-nitrobenzene derivative featuring additional tert-butyl, trifluoromethyl or methoxy groups; reduction...
AMA Wątor G, Kołton-Wróż M, Wołkow P, et al. No differences in miRNA expression the stroma of ERG+ and ERG– prostate cancers. Polish Journal Pathology. 2024:272-277. doi:10.5114/pjp.2023.134304. APA Wątor, G., Kołton-Wróż, M., Wołkow, P., Bełch, Ł., Chłosta, & Szpor, J. (2024). Pathology, 272-277. https://doi.org/10.5114/pjp.2023.134304 Chicago Gracjan, Maria Paweł Łukasz Piotr Joanna Agnieszka Klimkowska 2024. "No cancers". Pathology: Harvard J., Klimkowska, A., Nejman, K., Józkowicz,...
Abstract Background : The use of doxorubicin is associated with an increased risk acute and long-term cardiomyopathy. Despite the constantly growing number cancer survivors, little known about transcriptional mechanisms which progress in time leading to a severe cardiac outcome. It also unclear whether transcriptomic alterations related are similar patterns present patients suffering from other cardiomyopathies. Methods: We have sequenced miRNA total plasma extracellular vesicles (EVs) 66...
Abstract The use of doxorubicin is associated with an increased risk acute and long-term cardiomyopathy. Despite that the number cancer survivors growing constantly, little known about transcriptional mechanisms which progress in time leading to severe cardiac outcome. It also unclear whether transcriptomic alterations are related response doxorubicin. We have sequenced miRNA from total plasma extracellular vesicles (EVs) 66 lymphoblastic leukemia (ALL) treated 61 healthy controls (254...
Abstract The use of doxorubicin is associated with an increased risk acute and long-term cardiomyopathy. Despite the constantly growing number cancer survivors, little known about transcriptional mechanisms which progress in time leading to a severe cardiac outcome. It also unclear whether transcriptomic alterations related are similar patterns present patients suffering from other cardiomyopathies. Here we have sequenced miRNA total plasma extracellular vesicles (EVs) 66 childhood...