A5074974116- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Blood Pressure and Hypertension Studies
- Magnesium in Health and Disease
- Cancer, Hypoxia, and Metabolism
- Oral Health Pathology and Treatment
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Oral microbiology and periodontitis research
- Thermoregulation and physiological responses
- Chemokine receptors and signaling
- Lipid metabolism and disorders
- Single-cell and spatial transcriptomics
- Sphingolipid Metabolism and Signaling
- Cardiovascular Health and Disease Prevention
- Meta-analysis and systematic reviews
- Vagus Nerve Stimulation Research
Jagiellonian University
2015-2024
University of Glasgow
2016-2024
The Queen's Medical Research Institute
2023-2024
University of Edinburgh
2016-2024
British Heart Foundation
2016-2019
Inserm
2016
Centre de Recherche des Cordeliers
2016
John Paul II Hospital
2016
Abstract The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of clinical course COVID-19, its comorbidities, and mechanistic considerations for future therapies. While COVID-19 primarily affects lungs, causing interstitial pneumonitis severe acute respiratory distress syndrome (ARDS), it also multiple organs, particularly cardiovascular system. Risk infection mortality increase with...
Recent studies have emphasized the role of perivascular inflammation in cardiovascular disease. We studied mechanisms leukocyte infiltration angiotensin II (Ang II)-induced hypertension and their links to vascular dysfunction. Chronic Ang infusion mice increased immune cell content T cells (255 ± 130 1664 349 cells/mg; P < 0.01), M1 M2 macrophages, dendritic adipose tissue. In particular, lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, CCR5 receptors for RANTES was by (CCR1, 15.6...
Inflammation plays a key role in atherosclerosis. The protective of angiotensin 1-7 (Ang-(1-7)) vascular pathologies suggested the therapeutic use low MW, non-peptide Ang-(1-7) mimetics, such as AVE0991. mechanisms underlying vaso-protective effects AVE0991, Mas receptor agonist, remain to be explored.We investigated AVE0991 on spontaneous atherosclerosis apolipoprotein E (ApoE)-/- mice, context inflammation and plaque stability.AVE0991 has significant anti-atherosclerotic properties ApoE-/-...
Abstract Aims Transient Receptor Potential Melastatin 7 (TRPM7) cation channel is a chanzyme (channel + kinase) that influences cellular Mg2+ homeostasis and vascular signalling. However, the pathophysiological significance of TRPM7 in cardiovascular system unclear. The aim this study was to investigate role focusing on inflammation fibrosis. Methods results TRPM7-deficient mice with deletion kinase domain (TRPM7+/Δkinase) were studied molecular mechanisms investigated TRPM7+/Δkinase bone...
Rationale: Despite increasing understanding of the prognostic importance vascular stiffening linked to perivascular fibrosis in hypertension, molecular and cellular regulation this process is poorly understood. Objectives: To study functional role microRNA-214 (miR-214) induction endothelial dysfunction driving stiffening. Methods Results: Out 381 miRs screened tissues response Ang II (angiotensin II)-mediated miR-214 showed highest (8-fold, P =0.0001). MiR-214 was pronounced circulating T...
Inflammatory responses in small vessels play an important role the development of cardiovascular diseases, including hypertension, stroke, and vessel disease. This involves various complex molecular processes oxidative stress, inflammasome activation, immune-mediated responses, protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, DNA methylation, histone modifications, microRNAs influence vascular inflammation injury. These phenomena may be...
Emerging evidence indicates that hypertension is mediated by immune mechanisms. We hypothesized exposure to Porphyromonas gingivalis antigens, commonly encountered in periodontal disease, can enhance activation and exacerbate the elevation BP, vascular inflammation dysfunction.Th1 responses were elicited through immunizations using P. lysate antigens (10 μg) conjugated with aluminium oxide (50 IL-12 (1 μg). The endothelial dysfunction evoked subpressor doses of angiotensin II (0.25 mg·kg-1...
Cardiovascular disease is the major cause of morbidity and mortality in breast cancer survivors. Chemotherapy contributes to this risk. We aimed define mechanisms long-term vascular dysfunction caused by neoadjuvant chemotherapy (NACT) identify novel therapeutic targets. studied arteries from postmenopausal women who had undergone treatment using docetaxel, doxorubicin, cyclophosphamide with no history such matched for key clinical parameters. explored WT Nox4–/– mice human microvascular...
Abstract Vascular dysfunction is an important phenomenon in hypertension. We hypothesized that angiotensin II (AngII) affects transcriptome the vasculature a region-specific manner, which may help to identify genes related vascular AngII-induced Mesenteric artery and aortic was profiled using Illumina WG-6v2.0 chip control AngII infused (490 ng/kg/min) hypertensive mice. Gene set enrichment leading edge analyses identified Sphingosine kinase 1 (Sphk1) highest number of pathways affected by...
High blood pressure is a risk factor for cardiovascular diseases. Ang II (angiotensin II), key pro-hypertensive hormone, mediates target organ consequences such as endothelial dysfunction and cardiac hypertrophy. S1P (sphingosine-1-phosphate), produced by Sphk1 (sphingosine kinase 1), plays pivotal role in the pathogenesis of hypertension downstream damage, it controls vascular tone regulates remodeling. Accordingly, we aimed to examine if pharmacological inhibition using selective inhibitor...
Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue organs. Similarly, it one of earliest biological systems targeted by environmental stressors consequently involved in development progression ageing age-related disease. Microvascular dysfunction, if not targeted, leads to steady derangement phenotype, which cumulates comorbidities eventually results nonrescuable, very high-cardiovascular risk. Along broad spectrum pathologies, both...
Oral inflammation, such as periodontitis, can lead to endothelial dysfunction, accelerated atherosclerosis, and vascular dysfunction. The relationship between dysfunction other common forms of oral infections denture-related stomatitis (DRS) is unknown. Similar risk factors predispose both conditions including smoking, diabetes, age, obesity. Accordingly, we aimed investigate function major disease in 44 consecutive patients with dentures clinical microbiological features DRS (n = 20)...
Summary Intraluminal thrombus formation in aortic abdominal aneurysms (AAA) is associated with adverse clinical prognosis. Interplay between coagulation and inflammation, characterised by leukocyte infiltration cytokine production, has been implicated AAA formation. We studied (CD45+) content flow cytometry thrombi from 27 patients undergoing surgical repair. Luminal parts of were leukocyte-rich, while abluminal segments showed low content. CD66b+ granulocytes the most prevalent, but their...
Hypertension is associated with oxidative stress and perivascular inflammation, critical contributors to fibrosis accelerated vascular ageing. Oxidative can promote creating options for potential use of NADPH oxidase inhibitors in pharmacological targeting inflammation its consequences. Accordingly, we characterized age-related changes immune cell infiltration normotensive (WKY) spontaneously hypertensive rats (SHRs). Subsequently, used Nox1 (ML171) Nox1/Nox4 (GKT137831; 60 mg/kg), modulate...
Women with chronic hypertension are at increased risk of maternal and fetal morbidity mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model deficient uterine artery function adverse pregnancy outcome compared control Wistar-Kyoto. The activation immune system plays role in outcome. Therefore, we investigated tumor necrosis factor-α SHRSP phenotype an intervention study using etanercept (0.8 mg/kg SC) gestational days 0, 6, 12, 18...
Abstract Background and Purpose Hypertension is a multifactorial disease, manifested by vascular dysfunction, increased superoxide production, perivascular inflammation. In this study, we have hypothesized that 1,2,3,4,6‐penta‐ O ‐galloyl‐β‐ d ‐glucose (PGG) would inhibit inflammation protect from dysfunction in an experimental model of hypertension. Experimental Approach PGG was administered to mice every 2 days at dose 10 mg·kg −1 i.p during 14 Ang II infusion. It used final concentration...
Abstract Purpose Chronic inflammatory disorders of the oral cavity, such as periodontitis, were recently linked to systemic immune activation. Since fungal infections have not yet been studied in this respect, aim our study is determine whether local inflammation caused by infection palatal tissue (denture stomatitis—DS) associated with response. This question becoming essential population ages. Materials and Methods Peripheral blood DS patients (n = 20) control 24) was assessed flow...