A5023771039- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Lung Cancer Treatments and Mutations
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Urological Disorders and Treatments
- Hematological disorders and diagnostics
- Oral health in cancer treatment
- Histone Deacetylase Inhibitors Research
- PI3K/AKT/mTOR signaling in cancer
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Cancer Treatment and Pharmacology
Wroclaw Medical University
2018-2025
University of Wrocław
2022-2024
Cleveland Clinic
2023
Institut Gustave Roussy
2023
Poznan University of Medical Sciences
2011-2021
Fred Hutch Cancer Center
2021
Medical University of Białystok
2021
Szpital Kliniczny Nr 1 we Wrocławiu
2018-2020
University Hospital of Lord’s Transfiguration
2018
Hudson Institute
2016
Measurable residual disease (MRD) is an important biomarker in acute myeloid leukemia (AML) that used for prognostic, predictive, monitoring, and efficacy-response assessments. The European LeukemiaNet (ELN) MRD Working Party evaluated standardization harmonization of ongoing manner has updated the 2018 ELN recommendations based on significant developments field. New revised were established during in-person online meetings, a 2-stage Delphi poll was conducted to optimize consensus. All are...
The treatment of adults with Philadelphia-negative acute lymphoblastic leukaemia (ALL) depends on the presence risk factors including age, white blood cell count, immunophenotype and time to complete remission. In recent years, status minimal residual disease (MRD) has been postulated as an additional criterion. This study prospectively evaluated significance MRD. Patients were treated a uniform Polish Adult Leukemia Group (PALG) 4-2002 protocol. MRD was assessed after induction...
Measurable residual disease (MRD) quantified by multiparameter flow cytometry (MFC) is a strong and independent prognostic factor in acute myeloid leukemia (AML). However, several technical factors may affect the final read-out of assay. Experts from MRD Working Party European LeukemiaNet evaluated which aspects are crucial for accurate MFC-MRD measurement. Here, we report on agreement, obtained via combination cross-sectional questionnaire, live discussions, Delphi poll. The recommendations...
Randomized trial to assess change in left ventricle ejection fraction (LVEF) and myocardial perfusion patients with acute infarction (AMI) of anterior wall treated bone marrow stem cells (BMSCs), compared control group—from baseline the phase up 12 months follow-up. Forty-five were randomized 2:1 BMSC group (n= 31) or (n = 14). Bone administered into infarct-related artery (IRA) at 4–6 day after primary PCI. Groups followed Tc-99m-MIBI SPECT, radionuclide ventriculography (EF-RNV),...
Hematopoietic stem cell transplantation (HSCT) is a procedure commonly used in the treatment of various hematological disorders with aim curing patient or prolonging life. The vast majority patients must have antineoplastic therapy before HSCT, which can result weight loss, sarcopenia cachexia. Additionally, there high risk malnutrition and physical deterioration during HSCT. By assessing fitness prior to therapist individualize an exercise program, turn may speed up recovery after study was...
L-asparaginase is a hydrolase that catalyzes the conversion of L-asparagine--an endogenous amino acid necessary for function some neoplastic cells, such as lymphoblasts. In most human cells deficiency L-asparagine can be compensated by alternative synthesis pathway through which produced from aspartic and glutamine asparagine synthethase. Depletion plasma results in inhibition RNA DNA with subsequent blastic cell apoptosis. Owing to unique anti-cancer mechanism action, has been introduced...
Vaccination against SARS-CoV-2 is currently the best tool in fight COVID-19 pandemic. However, there are limited data on its efficacy and safety after hematopoietic stem cell transplantation (HCT). We present results of a prospective analysis humoral response to two doses BNT162b2 mRNA vaccine 93 adult patients, including 29 autologous HCT (autoHCT) 64 allogeneic (alloHCT). Positive anti-SARS-CoV-2 antibodies were detected before vaccination 25% patients despite negative medical history...
Some cancers treated with allogeneic hematopoietic stem cell transplantation (HSCT) are sensitive to natural killer (NK) reactivity. NK function depends on activating and inhibitory receptors is modified by education/licensing effect mediated coexpression of killer-cell immunoglobulin-like receptor (KIR) its corresponding HLA I ligand. We assessed KIR (aKIR)-based I-dependent education capacity in donor NKs 285 patients hematological malignancies after HSCT from unrelated donors. found...
Allogeneic hematopoietic cell transplantation (alloHCT) with myeloablative conditioning based on total body irradiation (TBI) is widely used for the treatment of adults acute lymphoblastic leukemia (ALL). TBI most frequently administered in combination either cyclophosphamide (Cy/TBI) or etoposide (Vp/TBI). The goal this study was to retrospectively compare these two regimens. Adult patients Ph-negative ALL treated alloHCT first second complete remission who received Cy/TBI (n = 1346) Vp/TBI...
The number of newly diagnosed haematological malignancies in Polish adults and children is about 9,000 a year, which constitutes 5.5% all the country. Adult patients with are treated 42 institutions Poland. scientific educational support for this activity provided under umbrella Society Haematologists Transfusiologists (PTHiT, Polskie Towarzystwo Hematologów i Transfuzjologów ), Leukemia Group (PALG), Lymphoma Research (PLRG), Myeloma Study (PMSG), Consortium (PMC), consultants haematology....
Background.Chronic graft-versus-host disease (cGvHD) is a complex disorder that typically manifests after allogeneic hematopoietic stem cell transplantation (HSCT).It major cause of non-relapse mortality, which makes finding biomarkers associated with its occurrence priority.Recent studies increasingly indicate microRNAs (miRNAs, short regulatory RNA molecules) can be used as various disorders.They circulate in patients' bodies encapsulated within extracellular vesicles (EVs).Objectives.To...
Among cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), some are sensitive to natural killer (NK) cell reactivity, described as the "missing self" recognition effect. However, this model disregarded NK licensing effect, which highly increases reactivity against tumor and is dependent on coexpression of inhibitory immunoglobulin-like receptor (iKIR) its corresponding HLA Class I ligand. We assessed clinical data, donor iKIR genotyping in 283 patients myelo-...
Development of modern proteomic methods in recent years has opened also new perspectives the identification biomarkers which ensure more effective diagnosis, treatment monitoring and prediction therapeutic outcome. We evaluated usefulness comparative proteomics (MALDI-TOF) two subtypes acute myeloid leukemia (AML), M1 M2, according to FAB classification. The bone marrow or blood cell proteomes were examined 33 newly diagnosed patients before "3 + 7" induction therapy, after when disease...
Catheter-related thrombosis (CRT) is a serious complication in hematological patients, but the risk factors for its occurrence are not well established. The study objectives were to estimate incidence of CRT and identify developing patients. In prospective setting, 104 consecutive patients with 200 insertions central venous catheters enrolled into study. screened by compression Doppler ultrasound every 10-14 days. Additionally, ultrasonography was performed case clinical symptoms suggesting...
Despite the well-defined role of autologous haematopoietic stem cell transplantation (autoHCT) in treatment patients with relapsed or refractory Hodgkin lymphoma (HL), relapse remains main cause transplant failure. We retrospectively evaluated long-term outcome and prognostic factors affecting survival 132 (n = 89) HL 43) treated autoHCT following modified BEAM. With a median follow-up 68 months, 10-year overall (OS) progression-free (PFS) were 76 66 %, respectively. The cumulative incidence...
The goal of therapy in essential thrombocythemia (ET) is reducing thrombotic risk. No algorithm to predict hemorrhage risk exists. impact ofanti-platelet, cytoreductive and anticoagulation therapies on major bleeding (MB) was evaluated. MB events were retrospectively analyzed 1381 ET from 10 European centers. There 0.286 events/person-year. Neither the International Thrombosis Prognostic Score for thrombosis (IPSET-t) nor revised IPSET-t (r-IPSET-t) predictive hemorrhage-free survival at...
Abstract Objectives In patients with essential thrombocythemia (ET), after the JAK2 V617F driver mutation, mutations in CALR are common (classified as type 1, 52‐bp deletion or 2, 5‐bp insertion). have generally been associated a lower risk of thrombosis. This study aimed to confirm impact mutation on thrombotic risk. Methods We retrospectively investigated 983 ET diagnosed Spanish and Polish hospitals. Results With 7.5 years median follow‐up from diagnosis, 155 (15.8%) had one more event....
This report is a retrospective analysis of 65 patients with peripheral T cell lymphoma (PTCL), who underwent high-dose therapy and autologous hematopoietic stem transplantation (autoHCT) as consolidation first response achieved either induction or salvage chemotherapy. We intended to determine the prognostic factors that influenced outcome after autoHCT define predictive value scoring systems most often applied for transplant outcomes. Nineteen in complete partial remission Forty-six...