Abstract Ulcerative colitis (UC) is a chronic immune-mediated disorder, whose etiology not fully understood and for which no effective treatment available. Recently, research has focused on the dysbiosis of gut microbiome in UC. However, results so far remain inconsistent insufficient to understand microbial component UC pathogenesis. In this study, we determine specific changes profile Polish patients compared healthy subjects first time. Using 16S rRNA gene-based analysis have described...

Background: Several perioperative inflammatory markers are postulated to be significant factors for long-term survival after off-pump coronary artery bypass surgery (OPCAB). Hematological parameters, whether single or combined as indices, provide higher predictive values. Methods: The study group comprised 538 consecutive patients (125 (23%) females and 413 (77%) males) with a mean age of 65 ± 9 years, who underwent OPCAB follow-up time 4.7 1.7 years. This single-center retrospective...

Vitamin D3 is a prohormone with pleiotropic effects, including modulating the functions of immune system and may affect effectiveness anti-PD-1 treatment in patients cancer. According to literature, potential mechanism vitamin D's influence on therapy most likely related amount activity tumor-infiltrating lymphocytes. There are data showing effect D cells regulating CD8 lymphocytes.A total 200 advanced melanoma were included study. All received immunotherapy (nivolumab or pembrolizumab) as...

The antioxidant capacity (AC) of boiled-type coffee brews (CB) and phenolic acids (PA) isolated from them, obtained the caffeinated decaffeinated beans different geographical origins species with roasting degrees, was examined. AC PA CB samples tested in five assays: a total antioxidants reducing assay using Folin–Ciocalteu reagent (FCR), ferric ion power (FRAP) assay, DPPH· radical-scavenging activity (DPPH) metal chelating (MCA) radical trapping parameter (TRAP) assay. In most samples,...

Cardiovascular diseases, apart from commonly known risk factors, are related to inflammation. There several simple novel markers proposed present the relation between inflammatory reactions activation and atherosclerotic changes. They easily available whole blood count include neutrophil lymphocyte ratio (NLR), monocyte (MLR), platelets (PLR). The RDW results were excluded analysis.The study based on retrospective single-centre analysis of 682 consecutive patients (131 (19%) females 551...

The goal of the study was to investigate possibility an association between polymorphisms and single alleles BsmI, ApaI, TaqI vitamin D receptor (VDR) gene with bone mineral density (BMD) prevalence vertebral/non-vertebral fractures in a group postmenopausal Polish women osteoporosis. comprised 501 females osteoporosis (mean age 66.4 ± 8.9), who were diagnosed on basis either WHO criteria or self-reported history low-energy fractures. three determined by PCR (polymerase chain reaction) RFLP...

Electroconvulsive therapy (ECT) is the most effective treatment for drug-resistant depression (DRD). We estimated short- and long-term effects of ECT on cognitive functions in patients with unipolar bipolar DRD.We investigated 63 (18 male, 45 female), aged 34-75 years. Cognitive assessments were performed before, immediately after 6-12 sessions, 3 months thereafter, using Benton Visual Retention, Trail Making (TMT), Rey-Osterrieth Complex Figure (ROCF) tests, Digit Span Wechsler Adult...

Introduction:Recent studies show that treatment of arterial hypertension is unsuccessful.This due to the patients' insufficient knowledge about therapeutic methods and consequences not treating hypertension. Objectives:The aim study was evaluate concerning options, prophylaxis, complications hypertension.The also assessed effect such on adherence efficacy.Patients Methods: The survey included 488 patients (250 female 238 male), aged over 18 years, diagnosed with treated in outpatient...

Background The aim of the study was to assess safety and glycemic outcomes with use a Do-It-Yourself (DIY) Hybrid Closed-Loop (HCL) system based on AndroidAPS application in type 1 diabetes (T1D). Methods Single-center clinical trial, 3-week run-in 12-week period. DIY HCL consisted Dana Diabecare RS insulin pump, Dexcom G5 continuous glucose monitoring application. Primary outcome safety: incidences severe hypoglycemia, diabetic ketoacidosis, time spent glycemia <54 mg/dl. Secondary...

Platelets participate in the development and progression of atherosclerosis. During this process they interact with endothelial cells leukocytes. Therefore, we investigated associations between carotid atherosclerosis platelet reactivity markers. The surface expression P-selectin (CD62P) activated GPIIb/IIIa receptor (corresponding to increased binding PAC-1), as well fraction platelet-derived microparticles (PMPs) prior after stimulation TRAP or ADP, were determined using flow cytometry 94...

Background: Off-pump coronary artery bypass grafting (OPCAB) comprises 15–30% of all surgeries. The currently available perioperative scores such as Euroscore and STS score do not specifically predict long-term mortality after off-pump procedures. neutrophil-to-lymphocyte ratio (NLR) is one the new, easily accessible markers inflammation with proven predictive value in cardiovascular diseases. We aimed to develop first risk for OPCAB determine if NLR predicts patients. Methods: In total, 440...

Statistical data on the use of various psychoactive substances indicate a narrowing previous differences in substance between men and women. Data from studies conducted among women suffering drug addiction are increasingly published, with authors highlighting specific needs this group difficulties that problems encounter. The current study aimed to identify barriers audience, both when seeking help during treatment. method used was secondary content analysis. To publications describing...

Background: Currently, atherosclerotic cardiovascular disease is the major cause of mortality world-wide. Inflammatory processes are postulated to be a driving force for coronary plaque initiation and progression can evaluated by simple inflammatory markers from whole blood count analysis. Among hematological indexes, systemic response index (SIRI) defined as quotient neutrophils monocytes, divided lymphocyte count. The aim present retrospective analysis was predictive role SIRI artery (CAD)...

As dedicated readers of Al-Kindy College Medical Journal, we are writing to highlight a critical and profoundly concerning matter that requires urgent research attention: the alarming surge in suicidal ideation among users Iraqi crystal methamphetamine. Expert psychiatrists at Baghdad City Ibn-Rushd Psychiatry Teaching Hospital have observed this worrisome trend. In tandem, previous studies regarding medical students revealed an unexpectedly high prevalence (64.9%). The escalating global...

Background: The study aimed to investigate the association between fat body mass and bone mineral density (BMD) of lumbar spine (L1–L4), femoral neck, total body. Methods: We studied 95 patients with Crohn’s disease (CD), 68 ulcerative colitis (UC), 40 healthy adults (control group—CG) aged 18–50 years old. BMD neck was assessed as well composition. Results: A lower percentage observed in about 8% CD, 13% UC, 3% CG. An increased common, occurred above 50% 40% 60% Body were significantly...

Impaired awareness of hypoglycemia (IAH) increases the risk severe hypoglycemia. Questionnaires may allow for easy identification patients with IAH and facilitate appropriate intervention. This study aims to assess clinical utility commonly used questionnaires diagnosing IAH, providing practical insight medical professionals. Additionally, we seek identify factors associated in adults type 1 diabetes (T1D), enhancing understanding this condition a real-world context. The included 252 T1D...

The aim of the study was to examine cytokine status in bipolar patients during immediate remission after acute episodes mania or depression and with sustained (≥6 months) remission, compared healthy controls.The performed on 121 patients, whom 35 were mania, 41 depression, 45 >6-month lithium monotherapy combined other drugs. control group consisted 78 individuals without any history psychiatric immunological illnesses. Serum concentrations IL-1β, IL-2, IL-6, IL-10, TNF-α IFN-γ determined...