A5086608791- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- CNS Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cutaneous lymphoproliferative disorders research
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Venous Thromboembolism Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Multiple and Secondary Primary Cancers
- Eosinophilic Disorders and Syndromes
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myeloid Leukemia Research
- Acute Myocardial Infarction Research
- Poisoning and overdose treatments
- Actinomycetales infections and treatment
- Biosimilars and Bioanalytical Methods
- Ear and Head Tumors
- Pericarditis and Cardiac Tamponade
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2015-2025
Agostino Gemelli University Polyclinic
2019-2024
Ospedale San Filippo Neri
2024
ASL Roma
2024
University of the Sacred Heart
2020
Advanced Radiation Therapy (United States)
2020
Sapienza University of Rome
2013-2015
Columbia University Irving Medical Center
2013
Abstract Vitamin D deficiency has been reported to be a negative prognostic factor in elderly patients with aggressive B‐cell lymphomas. In vitro data suggest that vitamin supplementation may enhance rituximab‐mediated cytotoxicity. We prospectively assessed 25‐hydroxyvitamin [25( OH )D] levels at diagnosis cohort of 155 lymphomas whom 128 had diffuse large lymphoma ( DLBCL ) not otherwise specified. 25( )D were deficient (<20 ng/mL) 105 (67%), insufficient (20–29 32 (21%), and normal...
Since the introduction of rituximab in late 1990s, significant progress has been made advancing targeted therapies for B cell lymphomas, improving patients’ chance being cured and clinicians’ therapeutic armamentarium. A better understanding disease biology pathogenic pathways, coupled with refinements immunophenotypic molecular diagnostics, have instrumental these achievements. While traditional chemotherapy remains fundamental most cases, concerns surrounding chemorefractoriness cumulative...
Background/Objectives: The treatment of older patients with classic Hodgkin lymphoma (eHL) remains a challenge. Methods: This study reports the first real-life survey eHL treated contemporary therapies in Italy. One hundred and fifty were between 2013 2018: seventy-one aged 60-69 years seventy-nine ≥70 (median age 70.5 years; range = 60-89). Curative treatments included ABVD-like regimens attenuated approaches alternating non-anthracycline-containing cycles. Results: After median follow-up...
Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing lymphoma via antibody-dependent cellular cytotoxicity (ADCC) mechanism. We evaluated the phenotypic functional assets peripheral blood NK cell subsets 32 newly-diagnosed diffuse large B-cell (DLBCL) patients 27 healthy controls. further monitored long-term modifications patient for up to 12 months after rituximab-based immunochemotherapy. At diagnosis,...
Abstract Image‐guided core needle biopsies (IG‐CNB) represent a minimally invasive approach for obtaining tissue in patients with lymphadenopathy and suspected lymphoma. Despite their utility, diagnostic challenges persist, lower efficacy compared excisional biopsies. Our study aimed to evaluate the potential utility of incorporation flow cytometry (FC) alongside immunohistochemistry (IHC) when performing IG‐CNB lymphoproliferative diseases. Analyzing 170 consecutive cases, guided by...
An association between Epstein–Barr Virus (EBV) infection and lymphoproliferative diseases has been reported with EBV + diffuse large B cell-lymphoma (DLBCL) of the elderly described as a distinct entity. In cohort 218 human immunodeficiency virus (HIV)-negative patients B-cell lymphomas, we detected EBV-DNA in 25% whole blood (WB) samples at diagnosis. Presence viral load WB, mononuclear cells or plasma did not predict presence tumor biopsy. Positive Hepatitis C (HCV) serology was...
The head-and-neck area is one of the most common sites for nodal and extranodal localization lymphomas. Clinical presentation lymphomas in head neck region varies from slowly growing indolent to highly aggressive causing compression upper airways which a timely diagnosis warranted. aim this study was evaluate predictive value flow cytometry (FC) lesions suspicious lymphoma. We analyzed cell suspensions 50 excisional biopsies using FC compared results with histological examination. Using...
In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was validate originally reported N/L cut-point 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered an Italian real-life database. role on event-free survival (EFS) overall (OS) assessed 505 DLBCL. Patients <3.5 (n = 249) had 4-year EFS probability 76% OS 86%, significantly higher than 4 year rate 48% 64% ≥3.5 256, both p<.0001)....
The primary objective of this prospective, randomized study was to compare the efficacy a reduced regimen only four doses unpegylated filgrastim from day +8 +11 per cycle with standard once administration pegylated maintain dose-intensity R-CHOP-14 (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone given every 14 d) in previously untreated elderly patients diffuse large B-cell lymphoma (DLBCL). We included 51 (median age 66 years, range 60-76). Median dose intensity did not...
IntroductionWhether pre-exposure prophylaxis (PrEP) with tixagevimab/cilgavimab 150mg/150 mg (T/C) in individuals hematological diseases (HD) may lead to a reduced risk of Breakthrough SARS CoV2 infection/hospitalization or death the Omicron era remains be established.MethodsObservational study including participants HD who received PrEP. breakthrough infections were defined as SARS-CoV-2 positivity by RT-PCR. The incidence (95%CI) and /hospitalization/death was calculated using Kaplan-Meier...
Abstract Hodgkin lymphoma (HL) is a neoplastic disease in which the inflammatory microenvironment plays pivotal role tumorigenesis. Neutrophilia typical finding HL at diagnosis and, particular, association with lymphocytopenia, negative prognostic factor. As immune checkpoint Programmed Death (PD)-L1/PD-1 has become an important therapeutic target, we were interested expression of PD-L1 peripheral blood (PB) leukocytes using flow cytometry and RT-PCR patients healthy controls. Granulocytes...
There is plenty of data confirming that hepatitis C virus (HCV) infection a predisposing factor for B-cell non-Hodgkin's lymphoma (B-NHL) outbreak, while relatively few reports have addressed the role HCV in affecting B-NHL patients' outcome. may influence short-term outcome because emergence severe hepatic toxicity (HT) during immunochemotherapy. Furthermore, long term HCV-related liver disease and quality life will possibly be affected by Rituximab maintenance, multiple-lines chemotherapy...
EUS-FNB has been introduced in clinical practice as a less invasive diagnostic approach with respect to surgery. We performed single-center retrospective study on the efficacy of EUS-guided FNB, including 171 patients lymph nodes, splenic, and extranodal lesions that underwent EUS for FNB at our institution. Excluding 12 who did not undergo 25 previous diagnosis solid tumor, we included 134 clinical/radiological suspect lymphoproliferative disease, 20 history lymphoma. Out biopsies, material...
The factual value of genome-wide association studies (GWAS) for the understanding multifactorial diseases is a matter intense debate. Practical consequences development more effective therapies do not seem to be around corner. Here we propose pragmatic and objective evaluation how much new biology arising from these studies, with particular attention information that can help prioritize therapeutic targets. We chose multiple sclerosis (MS) as paradigm disease assumed that, in pre-GWAS...
Large granular lymphocyte leukemias (LGLLs) represent a spectrum of biologically distinct lymphoproliferative diseases originating from either mature T cells (CD3+) or natural killer (NK) (CD3-). Both T-cell and NK-cell LGL leukemia can manifest as indolent aggressive neoplasia. These rare disorders are often associated with autoimmune impaired hematopoiesis. Symptomatic patients treated immunosuppressive drugs. The co-association T-LGLL clonal B-cell is reported in more than 10% patients.We...
We analyzed the prognostic impact of levels free light chains (FLC) in 106 patients with DLBCL, selecting 61 a monoclonal (M) protein serum, and 45 without M as an IPI-matched control group. Patients had higher FLC, but these were not significance this The presence nullified associations κ-FLC several laboratory parameters indicating immune system activation observed protein. >50 mg/L significant inferior event-free survival (p = .004). IgM type at diagnosis was negative outcome predictor...
Infection with SARS-CoV-2, the cause of coronavirus infectious disease-19 (COVID-19), has caused a pandemic. Few data are available about risk COVID-19 infection in persons hematological cancer, but controversy whether these have same clinical signs and outcomes. We describe case life-threatening complicated by severe anemia patients affected also chronic myelogenous leukemia. The screening for RBC antibodies direct antiglobulin test (DAT) turned positive. identification antibodies, showed...
We have studied the number of days alive outside Hospital (DAOH) and readmissions within first 100 after transplant in 185 patients who received an allogeneic hemopoietic stem cell (HSCT). The donors were matched siblings (SIB; n=61), or alternative (ALT; n=124). median DAOH for SIB transplants (78 days, range 21-84) was significantly greater than ALT donor grafts (73 2-87) (p=0.0003). Other positive predictors use reduced-intensity regimens (p=0.01), grade 0-I acute graft versus host...