A5001618847- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Multiple Myeloma Research and Treatments
- Erythrocyte Function and Pathophysiology
- Biomarkers in Disease Mechanisms
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Bone health and treatments
- Cancer Treatment and Pharmacology
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- CNS Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Cutaneous lymphoproliferative disorders research
- Rheumatoid Arthritis Research and Therapies
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
- SARS-CoV-2 and COVID-19 Research
- Acute Lymphoblastic Leukemia research
- Social and Behavioral Studies
- Burn Injury Management and Outcomes
- Renal Diseases and Glomerulopathies
- HIV-related health complications and treatments
- Syphilis Diagnosis and Treatment
Sechenov University
2024-2025
Burdenko Neurosurgery Institute
2014-2024
Military Hospital
2020-2024
Central Clinical Hospital
2024
Russian Railways
2021
A study was conducted with the participation of 51 male patients a confirmed diagnosis COVID‑19. 17 them were diagnosed anemia chronic diseases. The compared parameters hemogram, erythropoietin, iron metabolism (ferritin, transferrin, soluble transferrin receptor, total serum binding capacity (SIBC)), as well interleukin‑1b (IL‑1b), interleukin‑6 (IL‑6), interleukin‑10 (IL‑10), necrosis factor tumors alpha (TNF-α), interferon-γ (INF-γ) and C-reactive protein (CRP) in diseases (AСD) on...
The review contains data about new important aspects of pathogenesis, and treatment anemia chronic diseases. patients with diseases by erythropoiesis-stimulating agents iron is analyzed.
In December 2019, cases of severe respiratory infection were reported in Wuhan, China. The disease was caused by a new, previously undescribed coronavirus, structurally similar to the then known SARS-CoV virus. World Health Organization has named new virus SARS-CoV-2 and it causes COVID-19. problem COVID-19 is exacerbated rapid spread development life-threatening complications, main which pneumonia. Due severity condition, from 5 10 % patients are treated intensive care units. initially...
Aim. To develop based on the indicators of clinical blood tests, some biochemical markers, iron metabolism and cytokines a mathematical model that allows with high sensitivity specificity to conduct differential diagnosis anemia chronic diseases (AHD) deficiency (IDA) in patients inflammatory joint (rheumatoid arthritis (RA), psoriatic (PSA), ankylosing spondylitis (AS)). Material methods. The study included 104 anemic syndrome (37 males/67 females, age 48.4±5.42 years old), which 54 RA, 27...
Aim. To study the effect of hepcidin, soluble transferrin receptor (sTfR), and cytokines on iron metabolism occurrence anemia in patients with malignancies to propose, this basis, a draft classification chronic disease (ACD) based major pathogenic factor. Materials & Methods. The trial included 63 stage II/IV: 41 (34 men, 7 women, mean age 67.1 ± 9.9 years), 22 without (17 5 60.2 14.9 years). Comparative analysis was values metabolism, C-reactive protein (CRP), sTfR, as well...
Aim. To study the impact iron metabolism disturbances and cytokine levels on development of anemia in patients with solid tumors. Materials & Methods. The research included 42 malignant neoplasms, including 24 (19 men 5 women, median age 67.7 ± 10 years) 18 without (15 men, 3 65.7 14 years). Anemia was diagnosed according to WHO criteria (in men: erythrocytes < 4.0 <sup>x</sup> 10<sup>12</sup>/L, hemoglobin 130 g/L, hematocrit 39 %; women: 3.8 120 36 %)....
A comparative analysis of hemogram parameters, iron metabolism, C-reactive protein, hepcidin, soluble transferrin receptor in patients with malignant neoplasms, accompanied by anaemia and without it. Patients compared non-anaemic had lower haemoglobin, erythrocyte, hematocrit, mean corpuscular haemoglobin concentration, iron, saturation, total iron-binding capacity, higher levels (p0,05). Negative correlations moderate strength between hepcidin erythrocyte (r=-0,41), hemoglobin (r=-0,3),...
Objective : to study the importance of cytokines, hepcidin, a soluble transferrin receptor, iron metabolism in development anemia chronic diseases patients with malignant neoplasms and rheumatic pathology, identify leading factors for each studied groups develop working classification diseases. Materials methods . 63 pathology were examined. The group included 41 (17 men/24 women, average age 53.4 ± 4 years) anemia, control 22 (9 men/13 49.3 1.78 without anemia. (n = 63) stage II–IV (34...
Aim. To compare the secretion of interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-1-beta, tumor necrosis factor-alpha (TNF-α), interferon-gamma (INF-γ) in patients with HIV infection anemia chronic disease (ACD), iron deficiency (IDA), as well their combination. assess effect studied cytokines on erythropoiesis each types this category patients. Material and methods. 125 were examined: 101 (55 men, 46 women, 39.4±9.6 years), 24 without (13 11 mean age 37.6± 7.37 years). In...
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Background. The national observational program MPN-QoL-2020 was focused on quality of life (QoL) and symptoms in patients with classical Ph-negative myeloproliferative neoplasms (MPNs) the Russian Federation, as well perception disease treatment from patient's physician's perspective. Aim. To evaluate QoL different MPNs using new standardized questionnaires, to assess most common their impact myelofibrosis (MF), polycythemia vera (PV) essential throm-bocythemia (ET), characterize concerns...
Aim. To study the eff ect of hepcidin, soluble transferrin receptor (sTfR ), and cytokines on iron metabolism development anemia in rheumatologic patients, to propose a working version classifi cation chronic diseases (ACD) according major nosotropic factor. Material methods. 126 patients with rheumatic disease, 34 men (45.8 (36–54.9) years old), 92 women (49.5 (38–60) old) were examined. Group 1 included 41 ACD. 2 29 combination ACD IDA defi ciency (IDA). 3 — IDA. Control group 22 without...
Новая коронавирусная инфекция COVID-19 осложняет лечение и ухудшает прогноз у пациентов с заболеваниями системы крови. Проанализировав опыт одного гематологического стационара, оценили влияние новой коронавирусной инфекции на течение заболеваний крови исходы. В период февраля 2020 г. по март 2021 всего в гематологическом стационаре лечилось 1150 пациентов, каждый из которых получал 3-4 курса полихимиотерапии. Общее число инфицированных инфекцией составило 186 (16,7%). Летальных исходов от...
The article is devoted to the study of problem analysis degree osteoporosis based on results dual-energy x-ray absorptiometry in multiple myeloma during treatment. change bone mineral density patients with treated standard chemotherapy and high-dose autotransplantation hematopoietic stem cells considered. X-ray densitometry method can serve as an objective criterion for evaluating effectiveness treatment myeloma.
Aim . Identify risk factors for the development of osteodestructive syndrome. To determine relationship between types secreted monoclonal immunoglobulin (paraprotein) and severity syndrome in patients with paraproteinemic hemoblastoses (PH) Waldenström’s macroglobulinemia (WM). Materials methods. A retrospective analysis data from 116 PH WM was performed. 104 (89.6 %) were diagnosed multiple myeloma. Less commonly observed (in 8 – 6.9 %), plasma cell leukemia 2 1.8 solitary plasmacytoma...
Background. Anemia represents one of the most frequent complications in inflammatory bowel disease and severely impairs quality life affected patients. The etiology anemia patients can be multifactorial, often involving a combination iron deficiency chronic disease. choice therapy, focused on leading cause anemia, allows for individualized minimizing risk side effects cost therapy. Aim. A comparative analysis blood parameters before after treatment was performed. Materials methods. For 5...
Aim. To compare the secretion of erythropoietin in patients with infection caused by human immune deficiency virus (HIV infection) anemia chronic diseases (ACD), iron (IDA), and their combination. Material methods. 125 HIV were examined: 101 (55 males, 46 women, 39.4±9.6 years), 24 - a control group without (13 11 average age 37.6± 7.37 years). In all patients, number red blood cells, concentration hemoglobin, ferritin, C-reactive protein (CRP), transferrin saturation index (TSI) examined....
Цель. Анализ спектра выделенных на протяжении 2016–2022 гг. штаммов микроорганизмов, вызывавших инфекционные осложнения у пациентов онкогематологических отделений многопрофильного стационара; оценка уровня их резистентности для назначения своевременной антибактериальной терапии. Материалы и методы. Было проведено ретроспективное изучение микробиологических штаммов, в отделениях гематологического центра ГВКГ им. Н.Н. Бурденко от мужского женского пола различного возраста с диагнозами:...