A5043933219- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Extraction and Separation Processes
- Synthesis and biological activity
- Ionic liquids properties and applications
- Cancer therapeutics and mechanisms
- Organometallic Compounds Synthesis and Characterization
- Electrochemical Analysis and Applications
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Radioactive element chemistry and processing
- Lanthanide and Transition Metal Complexes
- Metal-Catalyzed Oxygenation Mechanisms
- DNA and Nucleic Acid Chemistry
- Analytical chemistry methods development
- Radiopharmaceutical Chemistry and Applications
- Geochemistry and Elemental Analysis
- Asymmetric Hydrogenation and Catalysis
- Magnetism in coordination complexes
University of Vienna
2016-2025
Ludwig Boltzmann Cluster for Cardiovascular Research
2019-2020
Faculty (United Kingdom)
2014-2020
Austrian Economics Center
2015-2020
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2016-2020
FH Campus Wien
2017
Translational Research in Oncology
2017
University of Auckland
2013
Czech Academy of Sciences, Institute of Inorganic Chemistry
2012
TU Wien
2004-2008
RuII(arene) complexes have been shown to be promising anticancer agents, capable of overcoming major drawbacks currently used chemotherapeutics. We synthesized RuII(η6-arene) compounds carrying bioactive flavonol ligands with the aim obtain multitargeted agents. To validate this concept, studies on mode action were conducted which indicated that they form covalent bonds DNA, only minor impact cell cycle, but inhibit CDK2 and topoisomerase IIα in vitro. The cytotoxic activity was determined...
Organometallic RuII, OsII and RhIII complexes of lapachol induce apoptosis in human tumour cell lines the low μM range by a mode action involving oxidative stress, especially case ruthenium compound.
RuII(arene)–flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
This study aims to develop novel ammonium and phosphonium ionic liquids (ILs) with thiosalicylate (TS) derivatives as anions evaluate their extracting efficiencies towards heavy metals in aqueous solutions. Six ILs were synthesized, characterized, investigated for efficacies cadmium, copper, zinc. Liquid-liquid extractions of Cu, Zn, or Cd after 1-24h using model solutions (pH 7; 0.1M CaCl2) assessed flame atomic absorption spectroscopy (F-AAS). Phosphonium-based...
Eight novel task-specific ionic liquids (TSILs) based on the thioglycolate anion designed for heavy metal extraction have been prepared and characterized by 1H 13C NMR, UV-Vis, infrared, ESI-MS, conductivity, viscosity, density thermal properties. Evaluation of their time-resolved abilities towards cadmium(II) copper(II) in aqueous solutions investigated where distribution ratios up to 1200 were observed. For elucidation IL mode, crystals grown Cd(II) was converted with an excess S-butyl...
Abstract Organometallic ruthenium–arene compounds bearing a maltol ligand have been shown to be nearly inactive in vitro anticancer assays, presumably due the formation of dimeric Ru II species aqueous solutions. In an attempt stabilize such complexes, [Ru(η 6 ‐ p ‐cymene)(XY)Cl] (XY=pyrones or thiopyrones) complexes with different substitution pattern (thio)pyrone ligands synthesized, their structures characterized spectroscopically, and aquation behavior investigated as well...
With the aim of exploring anticancer properties organometallic compounds with bioactive ligands, Ru(arene) antibacterial quinolones nalidixic acid (2) and cinoxacin (3) were synthesized, their physicochemical compared to those chlorido(η(6)-p-cymene)(ofloxacinato-κ(2)O,O)ruthenium(II) (1). All undergo a rapid ligand exchange reaction from chlorido aqua species. 2 3 are significantly more stable than 1 minor conversion an unreactive [(cym)Ru(μ-OH)(3)Ru(cym)](+) species (cym = η(6)-p-cymene)....
Hydroxypyr(id)ones are versatile ligands for the synthesis of organometallic anticancer agents, equipping them with fine-tunable pharmacological properties. Herein, we report on preparation, mode action, and in vitro activity RuII− OsII−arene complexes alkoxycarbonylmethyl-3-hydroxy-2-pyridone ligands. The hydrolysis binding to amino acids proceed quickly, as characterized by NMR spectroscopy ESI mass spectrometry. However, reaction causes cleavage pyridone from metal center because act...
Ru(II)(η(6)-arene) complexes, especially with bioactive ligands, are considered to be very promising compounds for anticancer drug design. We have shown recently that Ru(II)(η(6)-p-cymene) complexes 3-hydroxyflavone ligands exhibit high in vitro cytotoxic activities correlating a strong inhibition of topoisomerase IIα. In order expand our knowledge about the structure-activity relationships and determine impact lipophilicity arene ligand hydrolysis rate on activity, series novel derived were...
Ru(II)−arene complexes with pyrone-derived ligands are rendered active against cancer cells by replacement of the coordinated O,O donor an S,O donor. The different stabilities these systems may explain observed influence atoms on anticancer activity in vitro.
The synthesis and in vitro anticancer activity of OsII–arene complexes with carbohydrate-derived phosphite co-ligands are reported. compounds were characterized by standard methods the molecular structure dichlorido(η6-p-cymene)(3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-D-glucofuranoside)osmium(II) was determined X-ray diffraction analysis. Complexes chlorido leaving groups undergo hydrolysis consecutive formation aqua compounds, followed cleavage a P–O bond sugar ligands, as...
The thionated derivative of the antibacterial agent nalidixic acid and its organoruthenium complex were prepared, their crystal structures determined. aqueous stability was studied and, unlike case for nalidixicato complex, increased ruthenium in solution observed with only a minor degree thionalidixicato ligand dissociated within 1 week. While derivatization caused activity against E. coli to decrease, cytotoxicity three cancer cell lines significantly inhibitory potency two enzymes...
Organometallic Ru(arene)-peptide bioconjugates with potent in vitro anticancer activity are rare. We have prepared a conjugate of Ru(arene) complex the neuropeptide [Leu(5)]-enkephalin. [Chlorido(η(6)-p-cymene)(5-oxo-κO-2-{(4-[(N-tyrosinyl-glycinyl-glycinyl-phenylalanyl-leucinyl-NH2)propanamido]-1H-1,2,3-triazol-1-yl)methyl}-4H-pyronato-κO)ruthenium(II)] (8) shows antiproliferative human ovarian carcinoma cells an IC50 value as low 13 μM, whereas peptide or Ru moiety alone hardly cytotoxic....
The very promising results of Na-trans-[RuCl4(1H-indazole)2] (NKP-1339) in clinical studies have fuelled renewed interest the research and development ruthenium(III) coordination compounds for cancer therapy. By applying an improved synthetic approach to this class compounds, six new examples general formula (cation)-trans-[RuCl4(azole)2], where (cation) = tetrabutylammonium (Bu4N)(+) (1, 2), sodium (3, 4), azolium (5, 6), azole 1-methyl-indazole 3, 5), 1-ethyl-indazole (2, 4, been prepared....
Herein we report the synthesis, anticancer potency in vitro, biomolecule interaction, and preliminary mode of action studies a series cyclometalated 1,2,3-triazole-derived ruthenium(II) (2a-e) osmium(II) (3a-e) organometallics general form [(η6-p-cym)RuCl(κ2-C^N-L)] with varying substituents postion 1 1,2,3-triazole moiety. These cyclometalates were characterized by standard analytical methods their structures unambiguously assigned single crystal X-ray crystallography. The activity these...
Anticancer active metal complexes with biologically ligands have the potential to interact more than one biological target, which could help overcome acquired and/or intrinsic resistance of tumors small molecule drugs. In this paper we present preparation 2-hydroxy-[1,4]-naphthoquinone-derived and their coordination a Ru(II)(η(6)-p-cymene)Cl moiety. The synthesis oxime derivatives resulted in surprising formation nitroso-naphthalene complexes, as confirmed by X-ray diffraction analysis....
Ionic liquids (ILs) are per definition salts with melting points below 100°C and might be green alternatives for the extraction of heavy metals from aqueous solutions due to their favorable environmental physico-chemical properties. Partial solution during extraction, so-called leaching, however, limits applicability. The present study synthesizes three novel ammonium phosphonium ILs based on 3-hydroxy-2-naphthoic acid – trihexyltetradecylphosphonium- ([P66614]), methyltrioctylphosphonium-...
A series of monomeric and dimeric FeIII complexes with O,O-; O,N-; O,S-coordination motifs has been prepared characterized by standard analytical methods in order to elucidate their potential act as model compounds for aquatic humic acids. Due the postulated reduction iron acids following uptake microorganisms, redox behavior models was investigated cyclic voltammetry. Most showed potentials accessible biological reducing agents. Additionally, observed processes were predominantly...
Elemental analysis is a powerful analytical tool for purity determination. However, it prone to manipulations. Herein, we introduce an approach provide original elemental data, allowing verification of the currently just listed values.