A5043288358- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Lanthanide and Transition Metal Complexes
- Crystallography and molecular interactions
- Protein Interaction Studies and Fluorescence Analysis
- Ferrocene Chemistry and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Crystal structures of chemical compounds
- Drug Transport and Resistance Mechanisms
- Vanadium and Halogenation Chemistry
- Free Radicals and Antioxidants
- Molecular Sensors and Ion Detection
- Synthesis and biological activity
- Trace Elements in Health
- Magnetism in coordination complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Organometallic Complex Synthesis and Catalysis
- DNA and Nucleic Acid Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Organometallic Compounds Synthesis and Characterization
- Asymmetric Hydrogenation and Catalysis
- Click Chemistry and Applications
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
University of Szeged
2016-2025
Montavid Thermodynamic Research Group
2021
Comprehensive Cancer Center Vienna
2013
Medical University of Vienna
2013
University of Veterinary Medicine Vienna
2013
University of Vienna
2013
Instituto Superior Técnico
2006-2011
Instituto Politécnico de Lisboa
2011
University of Lisbon
2006-2010
University of Debrecen
1999-2007
Six morpholine-(iso)thiosemicarbazone hybrids HL1-HL6 and their Cu(II) complexes with good-to-moderate solubility stability in water were synthesized characterized. [Cu(L1-6)Cl] (1-6) formed weak dimeric associates the solid state, which did not remain intact solution as evidenced by ESI-MS. The lead proligands displayed higher antiproliferative activity cancer cells than triapine. In addition, 2-5 found to specifically inhibit growth of Gram-positive bacteria Staphylococcus aureus MIC50...
A series of water-soluble sodium salts 3-formyl-4-hydroxybenzenesulfonic acid thiosemicarbazones (or 5-sulfonate-salicylaldehyde thiosemicarbazones) containing different substituents at the terminal nitrogen atom (H, Me, Et, Ph) and their copper(ii) complexes have been prepared characterised by elemental analysis, spectroscopic techniques (IR, UV-vis, 1H NMR), ESI mass spectrometry, X-ray crystallography cyclic voltammetry. The proligands exhibit moderate water solubility good stability in...
The interactions of various insulin mimetic oxovanadium(IV) compounds with serum proteins were studied in model systems and ex vivo samples. For the modeling study, an earlier situ method was extended applied to formation ternary complexes apotransferrin (apoTf)–VIVO–maltol (mal) 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone (dhp). Both evaluated via simultaneous CD EPR measurements. Determination constants allowed calculation more accurate stability for VIVO–apoTf parent establishment a better...
Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for of thiol-containing tumour-targeting molecules like human serum albumin.
Ru(II)(η(6)-arene) complexes, especially with bioactive ligands, are considered to be very promising compounds for anticancer drug design. We have shown recently that Ru(II)(η(6)-p-cymene) complexes 3-hydroxyflavone ligands exhibit high in vitro cytotoxic activities correlating a strong inhibition of topoisomerase IIα. In order expand our knowledge about the structure-activity relationships and determine impact lipophilicity arene ligand hydrolysis rate on activity, series novel derived were...
A recently proposed strategy to overcome multidrug resistance (MDR) in cancer is target the collateral sensitivity of otherwise resistant cells. We designed a library 120 compounds explore chemical space around previously identified 8-hydroxyquinoline-derived Mannich bases with robust MDR-selective toxicity. included study effect halogen and alkoxymethyl substitutions R5 combination different R7, shift base from R7 R5, as well introduction an aromatic moiety. Cytotoxicity tests performed on...
We report the synthesis and characterization of three novel Schiff bases (L1-L3) derived from condensation 2-carbaldehyde-8-hydroxyquinoline with amines containing morpholine or piperidine moieties. These were reacted CuCl2 ZnCl2 yielding six new coordination compounds, general formula ML2, where M = Cu(II) Zn(II) L L1-L3, which all characterized by analytical, spectroscopic (Fourier transform infrared (FTIR), UV-visible absorption, nuclear magnetic resonance (NMR), electron paramagnetic...
We report the synthesis and characterization of a group benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH NH2, for L1-7, respectively; in L8 isonicotinohydrazide was used instead benzylhydrazide). Cu(II) complexes were prepared by reaction each benzoylhydrazone with acetate. All compounds characterized elemental analysis mass spectrometry as well FTIR, UV-visible absorption, NMR or...
There are a number of uncertainties regarding plasma protein binding and blood distribution the active drugs favipiravir (FAVI), molnupiravir (MOLNU) imatinib (IMA), which were recently proposed as therapeutics for treatment COVID-19 disease. Therefore, proton dissociation processes, solubility, lipophilicity, serum these three substances investigated in detail. The display various degrees lipophilicity at gastric (pH 2.0) pH 7.4). determined pKa values explain well changes lipophilic...
Abstract The interactions of Cu II , Zn and Fe with Triapine (3‐aminopyridine‐2‐carbaldehyde thiosemicarbazone), which is currently undergoing phase clinical trials as a chemotherapeutic antitumour agent, were investigated in water/DMSO mixture. proton‐dissociation constants the ligands, stability coordination modes metal complexes formed determined by pH‐potentiometric, UV/Vis spectrophotometric, EPR, 1 H NMR spectroscopic ESI‐MS methods. Two N‐terminally dimethylated derivatives also...
Stoichiometry and stability of GaIII, FeIII, FeII complexes Triapine five related α-N heterocyclic thiosemicarbazones with potential antitumor activity have been determined by pH-potentiometry, UV-vis spectrophotometry, 1H NMR spectroscopy, spectrofluorimetry in aqueous solution (with 30% DMSO), together the characterization proton dissociation processes. Additionally, redox properties iron were studied cyclic voltammetry at various pH values. Formation high bis-ligand was found all cases,...
The coordination modes of copper(II) complexes Schiff base-derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the mode ligands to be through N imine deprotonated phenol coumarin-derived ligand in solution. In addition, more active their corresponding presence liquid frozen solution ESR A series secondary amine derivatives base isolated with solubility characteristics...
Two enantiomerically pure thiosemicarbazone–proline conjugates with enhanced aqueous solubility, namely, 2-hydroxy-3-methyl-(S)-pyrrolidine-2-carboxylate-5-methylbenzaldehyde thiosemicarbazone [l-Pro-STSC or (S)-H2L] and 2-hydroxy-3-methyl-(R)-pyrrolidine-2-carboxylate-5-methylbenzaldehyde [d-Pro-STSC (R)-H2L] have been synthesized characterized by elemental analysis, spectroscopic methods (UV–vis 1H 13C NMR), electrospray ionization mass spectrometry. The metal complexation behavior of...
Two proline–thiosemicarbazone bioconjugates with excellent aqueous solubility, namely, 3-methyl-(S)-pyrrolidine-2-carboxylate-2-formylpyridine thiosemicarbazone [l-Pro-FTSC or (S)-H2L] and 3-methyl-(R)-pyrrolidine-2-carboxylate-2-formylpyridine [d-Pro-FTSC (R)-H2L], have been synthesized characterized by elemental analysis, one- two-dimensional 1H 13C NMR spectroscopy, electrospray ionization mass spectrometry. The complexation behavior of l-Pro-FTSC copper(II) in an solution a 30% (w/w)...