A5031458873- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Synthesis and bioactivity of alkaloids
- Synthesis and Characterization of Heterocyclic Compounds
- Crystal structures of chemical compounds
- Cancer Treatment and Pharmacology
- Magnetism in coordination complexes
- Synthesis and Biological Evaluation
- Metal-Catalyzed Oxygenation Mechanisms
- Microbial metabolism and enzyme function
- Metal-Organic Frameworks: Synthesis and Applications
- Organometallic Compounds Synthesis and Characterization
- Protein Interaction Studies and Fluorescence Analysis
- Metabolism and Genetic Disorders
- Synthesis and pharmacology of benzodiazepine derivatives
- Lanthanide and Transition Metal Complexes
- Multicomponent Synthesis of Heterocycles
- Free Radicals and Antioxidants
- Various Chemistry Research Topics
- Biological Activity of Diterpenoids and Biflavonoids
- Biochemical and Molecular Research
University of Vienna
2010-2024
Forestry Research Centre
2022
Université Grenoble Alpes
2020
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2015-2019
Austrian Economics Center
2015-2019
Faculty (United Kingdom)
2015
University of Rostock
1922-1928
Clinical Research Center Kiel
1888
Six morpholine-(iso)thiosemicarbazone hybrids HL1-HL6 and their Cu(II) complexes with good-to-moderate solubility stability in water were synthesized characterized. [Cu(L1-6)Cl] (1-6) formed weak dimeric associates the solid state, which did not remain intact solution as evidenced by ESI-MS. The lead proligands displayed higher antiproliferative activity cancer cells than triapine. In addition, 2-5 found to specifically inhibit growth of Gram-positive bacteria Staphylococcus aureus MIC50...
Two proline–thiosemicarbazone bioconjugates with excellent aqueous solubility, namely, 3-methyl-(S)-pyrrolidine-2-carboxylate-2-formylpyridine thiosemicarbazone [l-Pro-FTSC or (S)-H2L] and 3-methyl-(R)-pyrrolidine-2-carboxylate-2-formylpyridine [d-Pro-FTSC (R)-H2L], have been synthesized characterized by elemental analysis, one- two-dimensional 1H 13C NMR spectroscopy, electrospray ionization mass spectrometry. The complexation behavior of l-Pro-FTSC copper(II) in an solution a 30% (w/w)...
Strong enhancement of antiproliferative activity in human cancer cell lines was found upon coordination new hybrid ligands to copper(<sc>ii</sc>).
The antiproliferative activities of two new thiosemicarbazones as proligands and their Ni<sup>II</sup>, Pd<sup>II</sup>, Cu<sup>II</sup>complexes in cancer cells are reported this paper.
The synthesis of new modified indolo[3,2-c]quinoline ligands L1−L8 with metal-binding sites is reported. By coordination to ruthenium− and osmium−arene moieties 16 complexes the type [(η6-p-cymene)M(L)Cl]Cl (1a,b−8a,b), where M RuII or OsII L L1−L8, have been prepared. All compounds were comprehensively characterized by elemental analysis, electrospray ionization mass spectrometry, IR, UV−vis, NMR spectroscopy, thermogravimetric single-crystal X-ray diffraction (2a, 4a, 4b, 5a, 7a, 7b)....
A series of latonduine and indoloquinoline derivatives HL1–HL8 their copper(II) complexes (1–8) were synthesized comprehensively characterized. The structures five compounds (HL6, [CuCl(L1)(DMF)]·DMF, [CuCl(L2)(CH3OH)], [CuCl(L3)]·0.5H2O, [CuCl2(H2L5)]Cl·2DMF) elucidated by single crystal X-ray diffraction. revealed low micro- to sub-micromolar IC50 values with promising selectivity toward human colon adenocarcinoma multidrug-resistant Colo320 cancer cells as compared the...
Indolo[2,3-d]benzazepines (indololatonduines) are rarely discussed in the literature. In this project, we prepared a series of novel indololatonduine derivatives and their RuII OsII complexes investigated microtubule-targeting properties comparison with paclitaxel colchicine. Compounds were fully characterized by spectroscopic techniques (1H NMR UV-vis), ESI mass-spectrometry, X-ray crystallography, purity was confirmed elemental analysis. The stabilities compounds DMSO water 1H 13C UV-vis...
The nickel(II), copper(II), and zinc(II) complexes of the proline-thiosemicarbazone hybrids 3-methyl-(S)-pyrrolidine-2-carboxylate-2-formylpyridine thiosemicarbazone (l-Pro-FTSC or (S)-H2L1) 3-methyl-(R)-pyrrolidine-2-carboxylate-2-formylpyridine (d-Pro-FTSC (R)-H2L1), as well 4,4-dimethyl-thiosemicarbazone (dm-l-Pro-FTSC (S)-H2L2), namely, [Ni(l-Pro-FTSC–2H)]2 (1), [Ni(d-Pro-FTSC–2H)]2 (2), [Ni(dm-l-Pro-FTSC–2H)]2 (3), [Cu(dm-l-Pro-FTSC–2H)] (6), [Zn(l-Pro-FTSC–2H)] (7), [Zn(d-Pro-FTSC–2H)]...
Indolo[3,2-d][1]benzazepines (paullones), indolo[3,2-d][2]benzazepines, and indolo[2,3-d][2]benzazepines (latonduines) are isomeric scaffolds of current medicinal interest. Herein, we prepared a small library novel indolo[3,2-d][2]benzazepine-derived ligands HL1-HL4 copper(II) complexes 1-4. All compounds were characterized by spectroscopic methods (1H 13C NMR, UV-vis, IR) electrospray ionization (ESI) mass spectrometry, while 2 3, in addition, X-ray crystallography. Their purity was...
Four Schiff bases derived from 7-hydrazin-yl-5,8-dihydroindolo[2,3-d][2]benzazepin-(6H)-one and its bromo-substituted analogue (HL1-HL4) four copper(ii) complexes 1-4 have been synthesised fully characterised by standard spectroscopic methods (1H 13C NMR, UV-vis), ESI mass spectrometry, single crystal X-ray diffraction spectroelectrochemistry. In addition, two previously reported with paullone ligands 5 6 were prepared studied for comparison reasons. The CuII ion in is five-coordinate adopts...
The protection and promotion of agricultural niche products can be supported by the application analytical techniques able to link food its territory. This study aimed at exploring possibility discriminate between cereal samples from South Tyrol (Italy) neighboring regions (Trentino, East Tyrol, North Tyrol) their 87Sr/86Sr ratios. Soil grain (different species) were collected around 100 fields in two sampling campaigns. No difference ratios among different species (p < 0.05) was found when...
Exploring copper(<sc>ii</sc>) coordination from a new unsymmetrical naphthyridine-based ligand leads to the preparation of tetranuclear and trinuclear complexes. During complexation, one imine group is oxidized an amide group.
Paullone isomers are known as inhibitors of tubulin polymerase and cyclin dependent kinases (Cdks), which potential targets for cancer chemotherapy. Herein we report an efficient clean pathway to the fourth isomer, remained elusive so far, namely 7,8-dihydroindolo[2,3-d][1]benzazepin-6(5H)-one. Moreover, demonstrate generality our by synthesizing two closely related analogues, one containing a bromo substituent other incorporating 8-membered instead 7-membered ring. The key transformation in...