A5050922058- Vanadium and Halogenation Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Metal complexes synthesis and properties
- Trace Elements in Health
- Electrochemical Analysis and Applications
- Lanthanide and Transition Metal Complexes
- Radioactive element chemistry and processing
- Free Radicals and Antioxidants
- Heme Oxygenase-1 and Carbon Monoxide
- Crystallography and molecular interactions
- Drug Transport and Resistance Mechanisms
- Molecular Sensors and Ion Detection
- Chemical and Physical Properties in Aqueous Solutions
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Protein Interaction Studies and Fluorescence Analysis
- Cassava research and cyanide
- Chemical Synthesis and Characterization
- Protein Structure and Dynamics
- Alzheimer's disease research and treatments
- Fungal and yeast genetics research
- Polyoxometalates: Synthesis and Applications
- Microbial Natural Products and Biosynthesis
University of Szeged
2011-2024
Hungarian Academy of Sciences
2002-2012
University of Michigan
2009-2012
University of Ioannina
2008
University of Cyprus
2008
Aristotle University of Thessaloniki
2008
University of Crete
2002
University of Patras
2002
Foundation for Research and Technology Hellas
2002
Colorado State University
2000
The aqueous speciation, formation constants, and solution structure were determined for a new insulin-mimetic organic vanadium(V) compound (ammonium (dipicolinato)oxovanadate(V)). properties of the system characterized by using potentiometry, 1H, 13C, 51V NMR 1D 2D spectroscopy, UV/visible spectroscopy. These studies conducted crystalline as well combinations free ligand metal salt. major complex is most stable in acidic pH range, although it does protonate at low pH. It protonates ∼1...
The Schiff base N,N'-ethylenebis(pyridoxylideneiminato) (H(2)pyr(2)en, 1) was synthesized by reaction of pyridoxal with ethylenediamine; reduction H(2)pyr(2)en NaBH(4) yielded the reduced N,N'-ethylenebis(pyridoxylaminato) (H(2)Rpyr(2)en, 2); their crystal structures were determined X-ray diffraction. totally protonated forms 1 and 2 correspond to H(6)L(4+), all protonation constants pH-potentiometric (1)H NMR titrations. Several vanadium(IV) vanadium(V) complexes these other related ligands...
The interactions of various insulin mimetic oxovanadium(IV) compounds with serum proteins were studied in model systems and ex vivo samples. For the modeling study, an earlier situ method was extended applied to formation ternary complexes apotransferrin (apoTf)–VIVO–maltol (mal) 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone (dhp). Both evaluated via simultaneous CD EPR measurements. Determination constants allowed calculation more accurate stability for VIVO–apoTf parent establishment a better...
The understanding of the biotransformations insulin mimetic vanadium complexes in human blood and its transport to target cells is an essential issue development more effective drugs. We present study interaction oxovanadium(IV) with serum albumin (HSA) by electron paramagnetic resonance (EPR), circular dichroism (CD) visible absorption spectroscopy. Metal competition studies were done using CuII ZnII as metal probes. results show that VIVO occupies two types binding sites albumin, which...
Synthetic efforts targeting soluble species of Co(II) with the low molecular mass physiological ligand citric acid led to isolation first dinuclear complex [Co(2)(C(6)H(5)O(7))(2)(H(2)O)(4)](2-), at pH approximately 5, in form its K+ (1) and Na+ (2) salts. Both 1 2 were characterized analytically, spectroscopically (FT-IR, UV/visible, EPR), magnetically. Complex crystallizes monoclinic space group P2(1)/n, a = 10.348(5) A, b 11.578(6) c 12.138(6) beta 112.62(2) degrees, V 1342(1) A(3), Z 2....
The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone (dbcpe, 2) and N-methyl-2,3-dimethyl-5-hydroxy-6-carboxyamido-4-pyrimidinone (N-MeHOPY, 3), are synthesized their structures determined by single crystal X-ray diffraction. acid–base properties of 1 studied potentiometric spectrophotometric methods, the pKa values being 1.14 6.35. DFT calculations were carried out to determine most stable structure...
Abstract The Cu II and Ni complexes of the Schiff base pyr 2 en [ N , N′ ‐ethylenebis(pyridoxyliminato)] reduced bases Rpyr ‐ethylenebis(pyridoxylaminato)] R(SO 3 –sal) (SO –sal = salicylaldehyde‐5‐sulfonate) were prepared characterized by elemental analysis, IR, UV/Vis, EPR spectroscopy. structure Ni(pyr en) · 3H O was determined single‐crystal X‐ray diffraction. 2– ligand is coordinated through two phenolate‐O imine‐N atoms, in a distorted square‐planar geometry. complexation with aqueous...
Abstract The powerful combination of 113 Cd NMR and 111m PAC (perturbed angular correlation) spectroscopies has been critical to determine the coordination geometry II bound thiolate‐rich centers. We have obtained important linear correlations between spectroscopic data acid/base properties metal binding site that illustrate presence a dynamic model for (see figure). These unique results can give new insight into ‐substituted Zn proteins. magnified image used as probe zinc metalloenzymes...
Hydrothermal pH-specific reactivity in the binary/ternary systems of Pb(II) with carboxylic acids N-hydroxyethyl-iminodiacetic acid (Heida), 1,3-diamino-2-hydroxypropane-N,N,N′,N′-tetraacetic (Dpot), and 1,10-phenanthroline (Phen) afforded new well-defined crystalline compounds [Pb(Heida)]n·nH2O(1), [Pb(Phen)(Heida)]·4H2O(2), [Pb3(NO3)(Dpot)]n(3). All were characterized by elemental analysis, FT-IR, solution or/and solid-state NMR, single-crystal X-ray diffraction. The structures 1–2 reveal...
The speciations of two drug candidate ligands, 2-hydroxypyridine-N-oxide (Hhpno) and 2-mercaptopyridine-N-oxide (Hmpno), with vanadate (V(V)) were determined at 25.0 degrees C 0.20 mol dm(-3) KCl by pH-metric (51)V-NMR methods. At pH 7.4, the predominant compounds both ligands are VO(2)L(2) VO(2)L(OH). NH(4)[VO(2)(hpno)(2)] x 3 H(2)O was prepared in solid form, its crystal structure X-ray diffraction. stabilities complexes five compared 7.4. In view stability sequence hpno > maltol...
The calcium metallacrown Ca(II)[15-MC(Cu(II)N(Trpha))-5](2+) was obtained by self-assembly of Ca(II), Cu(II), and tryptophanhydroxamic acid. Its X-ray structure shows that the core ion is well-encapsulated in five oxygen cavity scaffold. kinetics Ca-Ln metal substitution studied visible spectrophotometry addition Ln(III) nitrate to solutions methanol solution at pH 6.2 (Ln(III) = La(III), Nd(III), Gd(III), Dy(III), Er(III)) obtain corresponding Ln(III)[15-MC(Cu(II)N(Trpha))-5](3+) complexes...
Abstract The interactions of bis‐V IV O‐1,2‐dimethyl‐3‐hydroxy‐4(1 H )‐pyridinone (DHP) with apotransferrin (apoTF) were followed by means electron paramagnetic resonance spectroscopy (EPR) at room temperature and liquid nitrogen temperature. Partial ligand displacement between DHP apoTF was observed, the reaction used to determine binding constant V O apoTF. A value log K = 14.3 ± 0.6 obtained for first In order confirm validity constant, UV monitor O–apoTF nitrilotriacetic acid (NTA)....