A5047084308- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Radiopharmaceutical Chemistry and Applications
- Ferrocene Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Click Chemistry and Applications
- Boron Compounds in Chemistry
- Organometallic Complex Synthesis and Catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Vanadium and Halogenation Chemistry
- Organometallic Compounds Synthesis and Characterization
- Magnetism in coordination complexes
- Nanoparticle-Based Drug Delivery
- Medical Imaging and Pathology Studies
- DNA and Nucleic Acid Chemistry
- Synthesis and Biological Evaluation
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Computational Drug Discovery Methods
- Crystal structures of chemical compounds
- Bone health and treatments
University of Lisbon
2016-2025
Hospital de Câncer de Barretos
2025
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento
2018-2024
Instituto Politécnico de Lisboa
2019-2024
Instituto Superior Técnico
2013-2023
National Institute of Engineering, Technology and Innovation
2023
University of Waterloo
2022
TARH (Portugal)
2004-2019
Secretaria do Meio Ambiente
2015
Centro Universitário Lusíada
2015
After uptake by U87 MG and A375 cancer cells, cobaltabisdicarbollide [COSAN]- distributes between membrane nucleus presents no relevant cytotoxicity against both cell lines even for long incubation times. The of Na[COSAN] was also tested towards one normal line, the V79 fibroblasts, in order to ascertain noncytotoxic profile compound. As cell's contains DNA, interaction double-stranded calf thymus DNA (CT-dsDNA) has been investigated. There is a strong molecules forming nanohybrid...
The interpretation of in vitro cytotoxicity data Cu(II)-1,10-phenanthroline (phen) complexes normally does not take into account the speciation that undergo cell incubation media and its implications cellular uptake mechanisms action. We synthesize test activity several distinct Cu(II)-phen compounds; up to 24 h incubation, cytotoxic differs for Cu corresponding free ligands, but longer times (e.g., 72 h), all compounds display similar activity. Combining use spectroscopic, spectrometric,...
Four complexes combining the {Ru(p-cym)} moiety (p-cym = para-cymene) with thiosemicarbazone (TSC) ligands containing 5-nitrofuryl pharmacophore were investigated in vitro for their properties as prospective anti-tumour agents. The compounds are dimeric structures of general formula [Ru2(p-cym)2(L)2]X2 where X Cl(-), PF6(-) and L deprotonated 5-nitrofuraldehyde TSC (L1), N-methyl (L2), N-ethyl (L3) N-phenyl (L4) derivatives. precursor [RuCl2(p-cym)]2, all L1-L4and corresponding 1-4 screened...
Ruthenium(II) complexes are currently considered a viable alternative to the widely used platinum as efficient anticancer agents. We herein present synthesis and characterization of half-sandwich ruthenium compounds with general formula [Ru(p-cymene)(L-N,N)Cl][CF3SO3] (L = 3,6-di-2-pyridyl-1,2,4,5-tetrazine (1) 6,7-dimethyl-2,3-bis(pyridin-2-yl)quinoxaline (2)), which have been synthesized by substitution reactions from precursor dimer [Ru(p-cymene)(Cl)(μ-Cl)]2 were characterized elemental...
The synthesis and characterization of one oxidoethoxidovanadium(V) [VVO(L1)(OEt)] (1) two nonoxidovanadium(IV) complexes, [VIV(L2–3)2] (2 3), with aroylhydrazone ligands incorporating naphthalene moieties, are reported. synthesized oxido nonoxido vanadium complexes characterized by various physicochemical techniques, their molecular structures solved single crystal X-ray diffraction (SC-XRD). This revealed that in 1 the geometry around atom corresponds to a distorted square pyramid, O4N...
Four new Cu(I) complexes of the general formula [Cu(PP)(LL)][BF4 ], in which PP is a phosphane ligand (triphenylphosphane or 1,2-bis(diphenylphosphano)ethane (dppe)) and LL bioactive thiosemicarbazone (4-(methyl)-1-(5-nitrofurfurylidene)thiosemicarbazone) 4-(ethyl)-1-(5-nitrofurfurylidene)thiosemicarbazone) were synthesized fully characterized by classical analytical spectroscopic methods. The anti-trypanosome anticancer activities investigated vitro on Trypanosoma cruzi two human cancer...
The biological properties of four lanthanide complexes with phenanthroline derivatives in ovarian cancer cells.
The limitations of platinum complexes in cancer treatment have motivated the extensive investigation into other metal such as ruthenium. We herein present synthesis and characterization a new family ruthenium compounds 1a-5a with general formula [Ru(bipy)2L][CF3SO3]2 (bipy = 2,2'-bipyridine; L bidentate ligand: N,N; N,P; P,P; P,As) which been characterized by elemental analysis, ES-MS, 1H 31P-{1H} NMR, FTIR conductivity measurements. molecular structures four Ru(ii) were determined single...
The aim of our study was to assess if the sodium salt cobaltabis(dicarbollide) and its di-iodinated derivative (Na[
This study investigated the phytochemical content of alcoholic extracts and essential oil a new variety medicinal plants, Agastache foeniculum (Pursh), which Kuntze adapted for cultivation in Romania, namely “Aromat de Buzău”. The was by GC-MS, while identification quantification various compounds from were performed HPLC-DAD. total phenol flavonoid contents evaluated using standard methods. antioxidant activities ethanol, methanol extracts, plant also assessed against...