Four new Cu(I) complexes of the general formula [Cu(PP)(LL)][BF4 ], in which PP is a phosphane ligand (triphenylphosphane or 1,2-bis(diphenylphosphano)ethane (dppe)) and LL bioactive thiosemicarbazone (4-(methyl)-1-(5-nitrofurfurylidene)thiosemicarbazone) 4-(ethyl)-1-(5-nitrofurfurylidene)thiosemicarbazone) were synthesized fully characterized by classical analytical spectroscopic methods. The anti-trypanosome anticancer activities investigated vitro on Trypanosoma cruzi two human cancer...

Searching for new prospective drugs against Chagas disease (American trypanosomiasis) and Leishmaniasis, a series of five heteroleptic vanadium compounds, [V IV O(L-H)(mpo)], where L are 8-hydroxyquinoline derivatives mpo is 2-mercaptopyridine N -oxide, synthesized characterized. Comprehensive characterizations conducted in solid state solution. The compounds evaluated on epimastigotes trypomastigotes Trypanosoma cruzi promastigotes Leishmania infantum , alongside VERO cells, as mammalian...

Chagas' disease (American Trypanosomiasis) is an ancient and endemic illness in Latin America caused by the protozoan parasite Trypanosoma cruzi. Although there urgent need for more efficient less toxic chemotherapeutics, no new drugs to treat this have entered clinic last decades. Searching metal-based prospective antichagasic drugs, work, multifunctional Re(I) tricarbonyl compounds bearing two different bioactive ligands were designed: a polypyridyl NN derivative of 1,10-phenanthroline...

The neglected illness Chagas disease is treated with limited efficacy and adverse effects by old drugs. Due to the low interest of pharmaceutical industry in targeting economically depressed-patients, repurposing a tool that should be applied because it can introduce new anti-Chagas entities into clinic at reduced costs. To investigate repurposing/combination medicines strategies as treatment. Epimastigotes, trypomastigotes amastigotes Trypanosoma cruzi were vitro exposed 28...

Diseases caused by trypanosomatid parasites are among the most pressing neglected illnesses. Chagas disease, Trypanosoma cruzi, and visceral Leishmaniasis, Leishmania infantum, have a severe health impact...

1,1′-Bis(diphenylphosphino)ferrocene pyridine-2-thiolato-1-oxide Pd(<sc>ii</sc>) and Pt(<sc>ii</sc>) hexafluorophosphate compounds showed cytotoxicity on <italic>T. cruzi</italic> <italic>M. tuberculosis</italic>.

Threads of dental implants with healing chamber configurations have become a target to improve osseointegration. This biomechanical and histometric study aimed evaluate the influence implant on torque removal value (RTv), percentage bone-to-implant contact (BIC%), bone fraction occupancy inside thread area (BAFO%), osteocyte density (Ost) in rabbit tibia after two months healing. Titanium three different were evaluated: Group 1 (G1), conventional "v" thread-shaped design; 2 (G2), square...

[V^IVO(L-H)₂] and [V^VO(OCH₃)(L-H)₂] compounds of 8-hydroxyquinoline derivatives L showed activity against<italic>Trypanosoma cruzi</italic>and<italic>Leishmania infantum</italic>and high selectivities. Metallomics interaction with BSA, apo-HTF DNA were studied.

Five heteroleptic compounds, [VVO(IN-2H)(L-H)], where L are 8-hydroxyquinoline derivatives and IN is a Schiff base ligand, were synthesized characterized in both the solid solution state. The compounds evaluated on epimastigotes trypomastigotes of Trypanosoma cruzi as well VERO cells, mammalian cell model. Compounds showed activity against with IC50 values 0.29–3.02 μM. ligand new [VVO2(IN-H)] complex negligible activity. most active compound [VVO(IN-2H)(L2-H)], L2 =...

Chagas disease is an endemic illness in Latin America caused by the parasite Trypanosoma cruzi . Current chemotherapies are old and inadequate, emergence of drug‐resistant strains underscores need new drugs. Platinum‐based complexes have been shown to be a promising approach against parasitic diseases. In this work, effect 1,1′‐bis(diphenylphosphino)ferrocene pyridine‐2‐thiolate‐1‐oxide Pt( II ) hexafluorophosphate, Pt‐dppf‐mpo, was studied on T. A antitrypanosomal activity determined for CL...

This study compared the osteogenic potential of two types bovine bone blocks. Blocks were obtained by either sintered or a nonsintered process. Calvaria surgically exposed in 20 rabbits. In each animal, six 0.5-mm-diameter cortical microperforations drilled with carbide bur before grafting to promote graft irrigation. The (group 1) and 2) blocks (6 mm diameter, 5 high) bilaterally screwed onto calvarial bone. previously prepared from larger block using trephine bur. Rabbits sacrificed after...

Manipulation of implant surface characteristics constitutes a promising strategy for improving cell growth and tissue response on variety materials with different topographies. Mesenchymal progenitor cells capacity to respond titanium stimuli differentiate into osteoblasts were used perform comparative tests between two topographies, including their functional interaction pre-osteoblasts directly seeded onto the implants. Functional analysis nanostructured surfaces was performed by in vitro...

The physical characteristics of an implant surface can determine and/or facilitate osseointegration processes. In this sense, a new with microgrooves associated plus double acid treatment to generate roughness was evaluated and compared in vitro vivo non-treated (smooth) treatment. Thirty disks thirty-six conical implants manufactured from commercially pure titanium (grade IV) were prepared for study. Three groups determined, as described below: Group 1 (G1), where the samples only machined;...

The purpose of the present study was to measure and compare insertion torque, removal implant stability quotient by resonance frequency analysis in different polyurethane block densities two macrogeometries. Four synthetic bone blocks were used with three cortical thickness: Bone 1 a thickness mm, 2 3 4, which totally cortical. groups created accordance macrogeometry (n = 10 per group) surface treatment: G1-regular design without treatment; G2-regular G3-new G4-new treatment. All implants 4...

Treatment for Chagas disease, a parasitosis caused by Trypanosoma cruzi , has always been based on two drugs, nifurtimox and benznidazole, despite the toxic side effects described after prolonged prescription. In this work, we study new prospective antitrypanosomal drug vanadium, here named V IV O(5Brsal)(aminophen). We found good IC 50 value, (3.76 ± 0.08) μ M, CL Brener epimastigotes. The analysis of cell death mechanism allowed us to rule out implication early apoptosis or necrosis....

Trypanosoma cruzi is a digenetic unicellular parasite that alternates between blood-sucking insect and mammalian, host causing Chagas disease or American trypanosomiasis. In the gut, differentiates from non-replicative trypomastigote forms arrive upon blood ingestion to non-infective replicative epimastigote forms. Epimastigotes develop into infective metacyclic trypomastigotes in rectum are delivered via feces. addition these stages, transitional have been reported. The insect-feeding...

Context: Triosephosphate isomerase (TIM) is a ubiquitous enzyme that has been targeted for the discovery of new small molecular weight compounds used against Trypanosoma cruzi, causative agent Chagas disease. We have identified phenazine and 1,2,6-thiadiazine chemotypes as novel inhibitors TIM from T. cruzi (TcTIM).Objective: Study mechanism TcTIM inhibition by derivative derivative.Methods: performed biochemical theoretical docking studies to characterize interaction derivatives with...

In this work, the physicochemical properties and in vitro bioactivity cellular viability of two commercially available bovine bone blocks (allografts materials) with different fabrication processes (sintered not) used for reconstruction were evaluated order to study effect microstructure behavior. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, mechanical resistance blocks, mercury porosimetry analysis, bioactivity, cell proliferation performed...

A new implant design with healing chambers in the threads was analyzed and compared a conventional macrogeometry, both implants models without surface treatment. Eighty conical were prepared using commercially pure titanium (grade IV) by company Implacil De Bortoli (São Paulo, Brazil). Four groups performed, as described below: Group 1 (G1), traditional treatment; group 2 (G2), treatment (machined surface); 3 (G3), 4 (G4), The placed two tibias (n = per tibia) of twenty New Zealand rabbits...