A5063181652- Glioma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Diamond and Carbon-based Materials Research
- Advanced MRI Techniques and Applications
- Iron Metabolism and Disorders
- Advanced NMR Techniques and Applications
- Laser-Ablation Synthesis of Nanoparticles
- Laser-induced spectroscopy and plasma
- Nanoplatforms for cancer theranostics
- Boron Compounds in Chemistry
- Boron and Carbon Nanomaterials Research
- High-pressure geophysics and materials
- MRI in cancer diagnosis
- Metal and Thin Film Mechanics
- NMR spectroscopy and applications
- Radiation Therapy and Dosimetry
- Electron Spin Resonance Studies
- Liver Disease Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Trace Elements in Health
- Characterization and Applications of Magnetic Nanoparticles
- Spinal Cord Injury Research
- Curcumin's Biomedical Applications
University of Turin
2017-2023
Torino e-district
2021
Multi-Modal Molecular Imaging Italian Node
2020
The aim of our study was to assess if the sodium salt cobaltabis(dicarbollide) and its di-iodinated derivative (Na[
Abstract The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a transmembrane heme exporter essential for embryonic vascular development. However, the exact role of FLVCR1a during blood vessel development remains largely undefined. Here, we show that highly expressed in angiogenic endothelial cells (ECs) compared to quiescent ECs. Consistently, ECs lacking give rise structurally and functionally abnormal networks multiple models developmental pathologic angiogenesis. Firstly,...
Rationale:The tireless research for effective drug delivery approaches is prompted by poor target tissue penetration and limited selectivity against diseased cells.To overcome these issues, various nanoand micro-carriers have been developed so far, but some of them are characterized slow degradation time, thus hampering repeated administrations.The aim this study was to pursue a selective magnetic biodegradable polyelectrolyte capsules in mouse breast cancer model, using an external...
Abstract This study aims to develop poly lactic-co-glycolic acid (PLGA) nanoparticles with an innovative imaging-guided approach based on Boron Neutron Capture Therapy for the treatment of mesothelioma. The herein-reported results demonstrate that PLGA incorporating oligo-histidine chains and dual Gd/B theranostic agent AT101 can successfully be exploited deliver a therapeutic dose boron mesothelioma cells, significantly higher than in healthy mesothelial cells as assessed by ICP-MS MRI....
Pyridoxamine, a structural analog of vitamin B6 that exerts antiglycative effects, has been proposed as supplementary approach in patients with initial diabetic nephropathy. However, the molecular mechanism(s) underlying its protective role so far slightly examined. C57Bl/6J mice were fed standard diet (SD) or enriched fat and fructose (HD) for 12 weeks. After 3 weeks, two subgroups SD HD started pyridoxamine supplementation (150 mg/kg/day) drinking water. showed increased body weight...
Medulloblastoma is the most common malignant brain tumor in children. Current treatment for medulloblastoma consists of surgery followed by irradiation whole neuraxis and high-dose multiagent chemotherapy, a partially effective strategy associated with highly invalidating side effects. Therefore, identification validation novel target molecules capable contrasting growth without disturbing development needed. Citron kinase protein (CITK), encoded primary microcephaly gene MCPH17, required...
A total of 20% to 50% prostate cancer (PCa) patients leave the surgery room with positive tumour margins. The intraoperative combination fluorescence guided (FGS) and photodynamic therapy (PDT) may be very helpful for improving margin delineation therapy. PSMA is a transmembrane protein overexpressed in 90–100% PCa cells. goal this work development PSMA-targeted Near InfraRed Fluorescent probe offer surgeon valuable tool allowing complete removal, implemented possibility using PDT kill...
Tumour-associated macrophages (TAM) are forced by cancer cells to adopt an anti-inflammatory phenotype and secrete factors promote tumour invasion thus being responsible for poor patient outcome. The aim of this study is develop a clinically applicable, non-invasive method obtain quantitative TAM detection in tissue. based on longitudinal proton relaxation rate (R1) measurements at low field (0.01-1 MHz) assess the localization ferumoxytol (clinical approved iron oxide particles) present...
Ensembles of negatively charged nitrogen-vacancy centers (NV-) in diamond have been proposed for sensing magnetic fields and paramagnetic agents, as a source spin-order the hyperpolarization nuclei resonance applications. To this end, strongly fluorescent nanodiamonds (NDs) represent promising materials, with large surface areas dense ensembles NV-. However, effects tend to favor less useful neutral form, NV0 centers, strategies increase density shallow NV- proposed, including irradiation...
The search for high relaxivities and increased specificity continues to be central the development of paramagnetic contrast agents magnetic resonance imaging (MRI). Ferritin, due its unique surface properties, architecture, biocompatibility, has emerged as a natural nanocage that can potentially help reach both these goals. This review aims highlight recent advances in use ferritin nanoplatform delivery metal-based MRI (containing Gd3+, Mn2+, or Fe2O3) alone combination with active molecules...
Labeling of macrophages with perfluorocarbon (PFC)-based compounds allows the visualization inflammatory processes by 19F-magnetic resonance imaging (19F-MRI), due to absence endogenous background. Even if PFC-labeling monocytes/macrophages has been largely investigated and used, information is lacking about impact these agents over polarization towards one their cell subsets on best way image them. In present work, a PFC-based nanoemulsion was developed monitor course inflammation in model...
Objectives The targeting of tumor cells and their visualization with magnetic resonance imaging (MRI) is an important task in biomedicine. low sensitivity this technique a significant drawback one that may hamper the detection reporters used. To overcome issue, work explores synergy between 2 strategies: (1) arginine, glycine, aspartic acid peptide (RGD)-functionalized giant unilamellar vesicles (GUVs) loaded Gd complexes to accumulate large amounts MRI contrast agent at site; (2) use...
This study aims to explore whether the water exchange rate constants in tumor cells can act as a hallmark of pathology status and reporter therapeutic outcomes. It has been shown, using 4T1 cell cultures murine allografts, that an early assessment effect doxorubicin be detected through changes cellular efflux constant kio. The latter estimated by analyzing magnetization recovery curve standard NMR T1 measurements when there is marked difference proton relaxation (R1) between intra-...
As conserving surgery is routinely applied for the treatment of early-stage breast cancer, need new technology to improve intraoperative margin assessment has become increasingly important. In this study, potential fast field-cycling 1H-NMR relaxometry as a diagnostic tool was evaluated. The technique allows determination tissue proton relaxation rates (R1), function magnetic field, which are affected by changes in composition mammary gland occurring during development neoplasia. study...
Herein a smart biomaterial self-monitoring the status of tissue implants by Fast Field Cycling MRI is described. It pH-sensitive, biocompatible, biodegradable and can non-invasively report on scaffold degradation cell proliferation.
Abstract Background The combination of imaging and therapeutic agents in the same smart nanoparticle is a promising option to perform minimally invasive guided therapy. In this study, Low density lipoproteins (LDL), one most attractive biodegradable biocompatible nanoparticles, were used for simultaneous delivery Paclitaxel (PTX), hydrophobic antitumour drug an amphiphilic contrast agent, Gd-AAZTA-C17, B16-F10 melanoma cell line. These cells overexpress LDL receptors, as assessed by flow...
Introduction Medulloblastoma (MB), the most common malignant pediatric brain tumor, is currently treated with surgery followed by radiation and chemotherapy, which accompanied severe side effects, raising need for innovative therapies. Disruption of microcephaly-related gene Citron kinase (CITK) impairs expansion xenograft models as well spontaneous MB arising in transgenic mice. No specific CITK inhibitors are available. Methods Lestaurtinib, a Staurosporine derivative also known CEP-701,...
<p>The file contains three supplementary figures with legends. Figure S1: Characterization of cell lines expressing CITK-specific shRNAs. S2: The expression CITK correlates MB patients'' prognosis and is highly expressed in mouse SmoA1 MB. S3: Engineering characterization conditional inactivation mice.</p>
<div>Abstract<p>Medulloblastoma is the most common malignant brain tumor in children. Current treatment for medulloblastoma consists of surgery followed by irradiation whole neuraxis and high-dose multiagent chemotherapy, a partially effective strategy associated with highly invalidating side effects. Therefore, identification validation novel target molecules capable contrasting growth without disturbing development needed. Citron kinase protein (CITK), encoded primary...
<p>The file contains three supplementary figures with legends. Figure S1: Characterization of cell lines expressing CITK-specific shRNAs. S2: The expression CITK correlates MB patients'' prognosis and is highly expressed in mouse SmoA1 MB. S3: Engineering characterization conditional inactivation mice.</p>
<div>Abstract<p>Medulloblastoma is the most common malignant brain tumor in children. Current treatment for medulloblastoma consists of surgery followed by irradiation whole neuraxis and high-dose multiagent chemotherapy, a partially effective strategy associated with highly invalidating side effects. Therefore, identification validation novel target molecules capable contrasting growth without disturbing development needed. Citron kinase protein (CITK), encoded primary...