A5047757593- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Nail Diseases and Treatments
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Bee Products Chemical Analysis
- Salivary Gland Disorders and Functions
- Nanoparticles: synthesis and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microencapsulation and Drying Processes
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- Calcium Carbonate Crystallization and Inhibition
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrohydrodynamics and Fluid Dynamics
- Electrospun Nanofibers in Biomedical Applications
- Adsorption, diffusion, and thermodynamic properties of materials
- Dendrimers and Hyperbranched Polymers
- Orbital Angular Momentum in Optics
Saratov State Medical University
2020-2024
Sechenov University
2020-2024
Molecular Theranostics (United States)
2024
Ministry of Health of the Russian Federation
2020-2023
Saratov State University
2015-2023
Public Health Dayton & Montgomery County
2023
Morpho (United States)
2023
Stomatology Hospital
2023
Ghent University
2017-2022
Saratov Research Center
2016-2020
We have designed multifunctional silver alginate hydrogel microcontainers referred to as loaded microcapsules with different sizes by assembling them via a template assisted approach using natural, highly porous calcium carbonate cores. Sodium was immobilized into the pores of particles followed cross-linking addition ions, which had dual purpose: on one hand, were used agent, albeit in monovalent form, while other hand they led formation nanoparticles. Monovalent an unusual improve...
Transdermal administration via skin appendages enables both localized and systemic drug delivery, as well minimizes incidental toxicity. However, the design of an appropriate effective method for clinical use remains challenging. Here, we introduce calcium carbonate-based carriers transdermal transportation bioactive substances. The proposed system presents easily manufacturable biodegradable particles with a large surface area enabling high payload ability. Topical application submicron...
Biocompatibility and high loading capacity of mesoporous CaCO3 vaterite crystals give an option to utilize the polycrystals for a wide range (bio)applications. Formation transformations calcium carbonate polymorphs have been studied decades, aimed at both basic applied research interests. Here, composite multilayer-coated containing Fe3O4 magnetite nanoparticles model protein lysozyme are fabricated. The structure → calcite recrystallization kinetics studied. results in release loaded...
Originally regarded as auxiliary additives, nanoparticles have become important constituents of polyelectrolyte multilayers. They represent the key components to enhance mechanical properties, enable activation by laser light or ultrasound, construct anisotropic and multicompartment structures, facilitate development novel sensors movable particles. Here, we discuss an increasingly role inorganic in layer-by-layer assembly—effectively leading construction so-called hybrid coatings. The...
Relevance . The high prevalence of periodontal diseases, late presentation patients, especially at the early stages, ineffectiveness provided treatment, and complex still-not-fully-understood mechanisms pathogenesis diseases render chronic generalized periodontitis (CGP) a socio-medical problem.The study aims to consider pathogenic which characterize development CGP. Materials methods conducted systematic literature search, included publications from 2005 2022. studies were found by...
A novel protocol for topical influenza immunization is reported. CaCO 3 carriers are used to deliver vaccine into hair follicles aiming target perifollicular antigen presenting cells. This approach represents a promising alternative injections.
Multifunctional silver alginate hydrogel microspheres are assembled <italic>via</italic> a template assisted approach using calcium carbonate cores.
A novel type of alginate hydrogel container: remote, non-destructive <italic>in vivo</italic> release through laser–nanoparticle interaction in <italic>C. elegans</italic>.
Polyelectrolyte microcapsules and other targeted drug delivery systems could substantially reduce the side effects of overall toxicity. At same time, cardiovascular system is a unique transport avenue that can deliver carriers to any tissue organ. However, one most important potential problems carrier systemic administration in clinical practice might cause circulatory disorders, development pulmonary embolism, ischemia, necrosis due blockage small capillaries. Thus, presented work aims find...
Rationale:The tireless research for effective drug delivery approaches is prompted by poor target tissue penetration and limited selectivity against diseased cells.To overcome these issues, various nanoand micro-carriers have been developed so far, but some of them are characterized slow degradation time, thus hampering repeated administrations.The aim this study was to pursue a selective magnetic biodegradable polyelectrolyte capsules in mouse breast cancer model, using an external...
Abstract Hair follicles (HF) represent a drug delivery reservoir for improved treatment of skin disorders. Although various particulate systems play an important role in HF‐targeting, their optical monitoring is challenging due to strong light scattering. Optical clearing effective approach allowing the increasing particle detection depth skin. The enhancement probing (OPD) and (ODD) localization using coherence tomography (OCT) was evaluated under application agents (OCAs) together with...
The photocatalytic degradation of organic molecules is one the effective ways for water purification. At this point, microreactor systems seem to be promising enhance versatility photoassisted approach. Herein, we propose photoresponsive microcapsules prepared via layer-by-layer assembly polyelectrolytes on novel CaCO3/TiO2 composite template cores. preparation particles challenging because poor compatibility TiO2 and CaCO3 in an aqueous medium. To prepare stable composites, nanoparticles...
In modern biomedical science and developmental biology, there is significant interest in optical tagging to study individual cell behavior migration large cellular populations. However, currently no system that can be used for labeling cells on demand situ with subsequent discrimination between long-term tracking of cells. this article, we demonstrate such a based photoconversion the fluorescent dye rhodamine B co-confined carbon nanodots volume micron-sized polyelectrolyte capsules. We show...
The search for novel therapeutic strategies to treat fungal diseases is of special importance nowadays given the emerging threat drug resistance. Various particulate delivery systems are extensively being developing enhance bioavailability, site-specific penetration, and efficacy antimycotics. Recently, we have designed a topical formulation griseofulvin (Gf) drug, which currently commercially available in oral dosage forms due its limited skin permeation. proposed based on vaterite carriers...
The development of advanced methods for the synthesis nano- and microparticles in field biomedicine is high interest due to a range reasons. current may have limitations terms efficiency, scalability, uniformity particles. Here, we investigate submicron calcium carbonate using microfluidic chip with T-shaped oil supply droplet-based facilitate control over formation design allowed precise manipulation reaction parameters, resulting improved porosity while maintaining an efficient rate. pore...
Superficial fungal infections are of serious concern worldwide due to their morbidity and increasing distribution across the globe in this era growing antimicrobial resistance. The delivery antifungals target regions skin sustaining effective drug concentration essential for successful treatment such mycoses. Topical formulations get extra benefits here if they penetrate into hair follicles since hyphae can proliferate produce spores reservoirs. We designed a novel particulate system...
The paradigm of drug delivery via nano- and microcarriers is one the leading ideas that enable overcoming limitations traditional chemotherapy. trend toward more complex carriers capable multifunctionality observed in literature. To date, prospects stimuli-responsive systems to control cargo release lesion nidus are widely accepted. Both endogenous exogenous stimuli employed for this purpose, however, pH most common triggers. Unfortunately, scientists face difficulties implementation idea...
Electrospun chitosan nanofibrous substrates are functionalized with silver nanoparticles by reduction of from Tollens reagent using glucose.Filling factor is estimated through developed protocol analysis scanning electron microscopy images.Obtained nanocomposite silver-chitosan plasmonic films display reliable surface enhanced Raman scattering signal rhodamine B the concentration 10 -5 M adsorbed onto substrates.