A5058983863- Gold and Silver Nanoparticles Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Polymer Surface Interaction Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Bio-sensing Technologies
- Photodynamic Therapy Research Studies
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Thermography and Photoacoustic Techniques
- Nanocluster Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Carbon Nanotubes in Composites
- Optical Imaging and Spectroscopy Techniques
- Blood properties and coagulation
- Silicon Nanostructures and Photoluminescence
- Plasmonic and Surface Plasmon Research
- Force Microscopy Techniques and Applications
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Porphyrin and Phthalocyanine Chemistry
- Infrared Thermography in Medicine
- Carbon and Quantum Dots Applications
- 3D Printing in Biomedical Research
Saratov State University
2015-2024
Saratov State Medical University
2022-2024
Moscow Institute of Physics and Technology
2018-2021
Saratov Research Center
2015-2018
Zero to Three
2011
Abstract Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecond‐laser ablation in liquids rapidly dissolve physiological‐like environment through oxidation mechanism. The is preserved tumor cells vitro and normal tissues mice half‐life short 3.5 days. Biocompatibility confirmed...
A wet-chemical approach is used to fabricate centimeter-scale gold nanoisland films (NIFs) with tunable morphology of islands and strong electromagnetic coupling between them. The consists in a uniform seeding small nanoparticles on glass or silicon substrate, followed by controllable growth the seeds into nanoislands. special technique for TEM sampling was developed follow gradual formation larger-sized isolated nanoparticles, nanoislands sintered overgrown seeds, complete layer nanoscale...
Abstract We demonstrate a novel approach to the controlled loading of inorganic nanoparticles and proteins into submicron- micron-sized porous particles. The is based on freezing/thawing cycles, which lead high densities. process was tested for inclusion Au, magnetite nanoparticles, bovine serum albumin in biocompatible vaterite carriers micron submicron sizes. amounts loaded or substances were adjusted by number cycles. Our method afforded at least three times higher four protein particles,...
Abstract Single‐wall carbon nanotubes modified by anionic polyelectrolyte molecules are embedded into the shells of microcapsules. Carbon serve as rigid rods in a softer polymeric capsule, which forms free‐standing shell upon treatment with glutaraldehyde and subsequent drying. The exhibit broad absorption UV–near‐infrared part spectrum, that allows point‐wise activation opening microcapsules laser. Raman signal analysis shows changes carbon‐nanotube‐specific lines after high‐power laser...
Photodynamic therapy (PDT) is a well-established cancer treatment method that employs light to generate reactive oxygen species (ROS) causing oxidative damage cells. Nevertheless, PDT encounters challenges due its oxygen-dependent nature, which makes it less effective in hypoxic tumor environments. To address this issue, we have developed novel nanocomposite known as AuNC@BBR@Ghost. This combines the advantageous features of erythrocyte ghost membranes, photoresponsive properties gold...
The impact of high-frequency (1.2 MHz) ultrasound with a power density 0.33 W cm(-2) on microcapsule nanocomposite shells embedded zinc oxide nanoparticles was investigated by exploring modeling simulations and direct visualization. For the first time sonication effect has been monitored in situ individual microcapsules upon exposure their aqueous suspension to ultrasound. stress distribution shell for high low (20 kHz) frequency at two fixed intensities (0.33 30 cm(-2)) modeled. As shown...
Microcapsules, made of biodegradable polymers, containing magnetite nanoparticles with tunable contrast in both the T1 and T2 MRI modes, were successfully prepared using a layer-by-layer approach. The microcapsules was shown to depend on distance between polymeric layers, which is controlled by their concentration microcapsule shell. A fivefold increase average shell led change intensity MR signal 100% for modes. Enzyme treatment shells resulted microcapsules' contrast. In vivo degradation...
A new type of bimodal contrast agent was made that is based on the self-quenching indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing local ICG concentration necessary for obtaining effect achieved by freezing-induced loading layer-by-layer assembly. As result, an efficient photoacoustic(optoacoustic)/fluorescent composite green/polymer particles successfully prepared characterized fluorescence photoacoustic(optoacoustic) tomography vitro....
Toxicity of reduced graphene oxide (rGO) has been a topic multiple studies and was shown to depend on variety characteristics rGO biological objects interest. In this paper, we demonstrate that when studying the same dispersions fluorescent Escherichia coli (E. coli) bacteria, outcome nanotoxicity experiments also depends type culture medium. We show inhibits growth bacteria in nutrition medium but shows little effect behavior E. physiological saline solution. The observed effects different...
Polyelectrolyte microcapsules and other targeted drug delivery systems could substantially reduce the side effects of overall toxicity. At same time, cardiovascular system is a unique transport avenue that can deliver carriers to any tissue organ. However, one most important potential problems carrier systemic administration in clinical practice might cause circulatory disorders, development pulmonary embolism, ischemia, necrosis due blockage small capillaries. Thus, presented work aims find...
Surface-enhanced Raman scattering (SERS) performance of Au nanorods (AuNRs) can be enhanced by the tip adsorption molecules (RMs) through anisotropic polymer stabilization or embedding RMs between AuNR cores and Ag shells AuNR@RM@Ag composite particles. We propose a new strategy to design ultrabright SERS probes composed high-aspect-ratio AuNRs with coatings, preferred open tips. Specifically, for 4-nitrobenzenethiol (NBT) concentrations above threshold value c > ctr, fabricated Au@NBT@Ag...
Surface-enhanced Raman scattering (SERS) is widely used for in vitro and vivo bioimaging applications. However, reproducible controllable fabrication of SERS tags with high density electromagnetic hot-spots still challenging. We report an improved strategy the synthesis core/shell immobilization reporter molecules. The based on simultaneous growth functionalization Au shell around nanospheres coated 4-nitrobenzenethiol (NBT). amount added 4-NBT key factor to control structure response...
Magnetic contrast agents are widely used in magnetic resonance imaging order to significantly change the signals from regions of interest comparison with surrounding tissue. Despite a high variety single-mode T1 or T2 agents, there is need for dual-mode one agent. Here, we report on synthesis submicron carriers, containing Fe3O4 nanoparticles their structure. We show ability control by changing not only number magnetite carrier concentration suspension but also structure core–shell itself....
Abstract We present the results of using Raman molecular imaging and atomic force microscopy (AFM) investigation composition, stability, photodegradation polyelectrolyte multilayer microcapsules coated microparticles containing copper–phthalocyanine iron–phthalocyanine. The influence laser light on degradation these phthalocyanine dyes embedded in walls capsules shells was studied by both AFM imaging, but only latter technique gave information dynamics photodegradation. peak assignment...