A5028348562- Luminescence Properties of Advanced Materials
- Nanoplatforms for cancer theranostics
- Photopolymerization techniques and applications
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Ultrasound and Hyperthermia Applications
- 3D Printing in Biomedical Research
- Advanced Polymer Synthesis and Characterization
- Nonlinear Optical Materials Studies
- Additive Manufacturing and 3D Printing Technologies
- Quantum Dots Synthesis And Properties
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Laser-Ablation Synthesis of Nanoparticles
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Plasmonic and Surface Plasmon Research
- Silicone and Siloxane Chemistry
- Galectins and Cancer Biology
- Biosensors and Analytical Detection
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
Moscow State Pedagogical University
2023-2024
Federal Scientific Research Centre Crystallography and Photonics
2018-2024
Institute of Bioorganic Chemistry
2018-2024
Kurchatov Institute
2024
Russian Academy of Sciences
2018-2023
Photochemistry Center
2023
Moscow State University of Fine Chemical Technologies
2014-2019
Lomonosov Moscow State University
2014-2019
MIREA - Russian Technological University
2018
The progress in the field of tissue engineering is largely driven by development 3D laser printing technologies, which allow precise creation hydrogel scaffolds containing cells (the so-called tissue-engineered constructs), using photoinduced radical reactions polymerization and crosslinking. review considers main mechanisms features such reactions, presents most common materials for photocompositions, including natural synthetic polymers precursors, describes various photoinitiator...
Abstract In this paper, we have investigated the optical properties of a newly synthesized material consisting few-nm-thin flakes ruby Al 2 O 3 :Cr 3+ , referred to as rubyene . Both theoretical and experimental approaches focus on photoluminescence Cr particularly exploring effects refractive index surrounding medium radiative nonradiative lifetimes chromium ions, consequences diverse shapes thin flakes. Notably, demonstrate how such susceptibility allows for insight into orientation...
Biological nanoparticles (NPs), such as extracellular vesicles (EVs), exosome-mimetic nanovesicles (EMNVs) and nanoghosts (NGs), are perspective non-viral delivery vehicles for all types of therapeutic cargo. NPs renowned their exceptional biocompatibility safety, alongside ease functionalization, but a significant challenge arises when attempting to load payloads, nucleic acids (NAs). One effective strategy involves fusing biological with liposomes loaded NAs, resulting in hybrid carriers...
Non-cytotoxic upconversion nanoparticles decorated with colominic acid exhibit the prolonged circulation time in bloodstream compared to PEG leading their effective accumulation inflammation site and visualization of blood vessels.
Photopolymerization of nanocomposite materials using near infrared light is one the unique technologies based on luminescent properties lanthanide-doped upconversion nanoparticles (UCNPs). We explored UCNP-triggered radical polymerization both in oligomer bulk and nanoparticle surface aqueous dispersion. Core/shell UCNPs NaYF4:Yb3+ Tm3+/NaYF4 with emitting lines ultraviolet blue regions were used to activate a photoinitiator. The study photopolymerization an initially homogeneous reaction...
Formulation of promising anticancer herbal drug curcumin as a nanoscale-sized (nanocurcumin) improved its delivery to cells and organisms both in vitro vivo. We report on coupling nanocurcumin with upconversion nanoparticles (UCNPs) using Poly (lactic-co-glycolic Acid) (PLGA) endow visualisation the near-infrared transparency window. Nanocurcumin was prepared by solvent-antisolvent method. NaYF4:Yb,Er (UCNP1) NaYF4:Yb,Tm (UCNP2) were synthesised reverse microemulsion method then...
Abstract The development of nanozymes, artificial enzymes made from inorganic nanoparticles, is widely studied due to their affordability, durability, and strength. Gold nanoparticles (AuNPs) are employed imitate peroxidase, glucose oxidase, lactate superoxide dismutase, catalase. last one transforms intracellular hydrogen peroxide into molecular oxygen, whose deficiency characteristic the hypoxic tumor microenvironment. Thus, gold thought enhance overall effectiveness photodynamic therapy....
Biological nanoparticles (NPs), such as extracellular vesicles (EVs), exosome-mimetic nanovesicles (EMNVs) and nanoghosts (NGs), are perspective non-viral delivery vehicles for all types of therapeutic cargo. NPs renowned their exceptional biocompatibility safety, alongside ease functionalization, but a significant challenge arises when attempting to load payloads, nucleic acids (NAs). One effective strategy involves fusing biological with liposomes loaded NAs, resulting in hybrid carriers...
Microbubbles are routinely used ultrasound contrast agents in the clinic. While a soft protein shell is commercially preferable for imaging purposes, rigid polymer demonstrates prolonged agent stability. Hence, combining polymers and proteins one composition can advance microbubble properties. We formulated hybrid "protein–copolymer" with complex of bovine serum albumin an amphiphilic copolymer N-vinyl-2-pyrrolidone acrylic acid. The resulting microbubbles demonstrated advanced...
Proteolytic activity is pivotal in maintaining cell homeostasis and function. In pathological conditions such as cancer, it covers a key role tumor viability, spreading to distant organs, response the treatment. Endosomes represent one of major sites cellular proteolytic very often final destination internalized nanoformulations. However, little information about nanoparticle impact on biology these organelles available even though they location drug release. this work, we generated albumin...
Frontiers in theranostics are driving the demand for multifunctional nanoagents. Upconversion nanoparticle (UCNP)-based systems activated by near-infrared (NIR) light deeply penetrating biotissue a powerful tool simultaneous diagnosis and therapy of cancer. The intercalation into large polymer micelles poly(maleic anhydride-alt-1-octadecene) provided creation biocompatible UCNPs. intrinsic properties UCNPs (core@shell structure NaYF4:Yb3+/Tm3+@NaYF4) embedded delivered NIR-to-NIR...
Förster resonance energy transfer (FRET) provides a unique means to probe processes occurring on the nanoscale. Efficient point-to-plane FRET between acceptors arrayed in two-dimensional (2D) sheets and point-dipole donors is known exhibit an proportional d–4, where d distance from donor acceptor-plane. We developed 2D nanomaterial with surface-adjacent based chromium-doped aluminum oxide (ruby) that supports 2D-FRET architecture. Ruby exhibits bright, narrow-band photoluminescence long...
The detection of double bonds in polymers exploited as scaffold materials, e.g. hyaluronic acid (HA) derivatives, is crucial for their further applications. quantity variations unsaturated units significantly affect the photoinduced crosslinking degree responsible mechanical properties scaffolds. We demonstrate a simple, selective and rapid quantitative method that enables bond moieties polymers. approach based on reaction with potassium permanganate which spectrophotometrically confirmed....
Технология 3D-печати стала ключевой движущей силой в изменении парадигмы производственного процесса различных отраслях промышленности. Новой вехой может стать технология инфракрасной полимеризации, основанная на достижениях области синтеза наноматериалов, способных эффективно преобразовывать излучение ближнего ИК-диапазона спектра УФ-свет. Эта инновационная проложить путь к разработке множества решений промышленности и предвещает новые рубежи для фотоники, оптоэлектроники биомедицины. В...
Upconversion nanoparticle (UCNP)-driven polymerization attracts great attention due to the ability of near-infrared light penetrate deeper into biological media and synthetic materials than ultraviolet or visible light. Despite significant progress, limitation light-triggered is associated with a key element photocurable composition, UCNP/photoinitiator complex nanoinitiator. To determine impact resonance energy transfer from UCNPs photoinitiator (PI) its effect on polymerization, we...
Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for biosensing. However, SERS analysis has several concerns: the signal limited by number of molecules and area plasmonic substrate in laser hotspot, quantitative low-volume droplet confusing due to change concentration during quick drying. The usage hollow-core microstructured optical fibers (HC-MOFs) thought be an effective way improve sensitivity limit detection through irradiation small sample volume filling fiber...
Implementation of up-to-date 3D printing methods for tissue engineering applications requires synthesis novel materials possessing both biocompatibility and processability properties. Since the hyaluronic acid is an endogenous material it represents attractive candidate scaffold formation. In this work, chemical modification with glycidyl methacrylate (HAGM) was used to produce derivatives that are capable photoinduced cross-linking. Aiming control degree substitution in by we developed a...
Extracellular vesicles (EVs), biomimetics, and other biological nanoparticles (BNs) produced from human cells are gaining increasing attention in the fields of molecular diagnostics nanomedicine for delivery therapeutic cargo. In particular, BNs considered prospective vehicles different biologics, including protein RNA therapeutics. Moreover, EVs widely used early detection disease-associated proteins RNA. Technical approaches measuring biologics mostly originated field were later adopted...
В статье показан потенциал практического использования метода оптической микроскопии дорсальной кожной складки в качестве эффективной технологии диагностики живых систем. Экспериментально доказано, что даже базовой постановке представленный метод позволяет получать большой объем полезных исследовательских данных условиях, максимально приближенных к нативным.
BACKGROUND: There is an urgent need to develop new platinum-based anti-tumor agents that are both more effective and less toxic. One strategy for developing these drugs the synthesis of Pt(IV) prodrugs, which precursor complexes cisplatin its analogues capable releasing active Pt(II) directly into intracellular environment malignant neoplasms. To identify optimal method in vivo administration a drug, it essential assess acute toxicity biodistribution vital organs. AIM: Study tolerability,...
Lanthanide-based upconversion nanoparticles attach great attention in theranostics due to their unique physicochemical and optical properties. It is innovative platform possessing peculiar properties for luminescent imaging, temperature mapping, sensing, therapy. In present work we demonstrate advantages of new agents based on hydrophylic biocompatible polymer.