A5055136443- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Protease and Inhibitor Mechanisms
- Advanced biosensing and bioanalysis techniques
- Blood Pressure and Hypertension Studies
- Neonatal Respiratory Health Research
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Neonatal and fetal brain pathology
- Electron and X-Ray Spectroscopy Techniques
- Diatoms and Algae Research
- Nanoparticles: synthesis and applications
- Surface Modification and Superhydrophobicity
- Lipid Membrane Structure and Behavior
- Modular Robots and Swarm Intelligence
- Carbon Nanotubes in Composites
- Force Microscopy Techniques and Applications
- Immunotherapy and Immune Responses
- Advanced Materials Characterization Techniques
- Cell Adhesion Molecules Research
- Nanofabrication and Lithography Techniques
- Surface and Thin Film Phenomena
- Photonic and Optical Devices
Istituto Giannina Gaslini
2008-2025
Sirius University of Science and Technology
2021-2025
Lomonosov Moscow State University
2025
University of Genoa
2005-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2008-2024
Sechenov University
2019-2023
Azienda Mobilità e Trasporti
2022
Houston Methodist
2012-2020
SDN Istituto di Ricerca Diagnostica e Nucleare
2014-2020
Ospedale Policlinico San Martino
2006-2020
Cancer is still considered a lethal disease worldwide and the patients’ quality of life affected by major side effects treatments including post-surgery complications, chemo-, radiation therapy. Recently, new therapeutic approaches were globally for increasing conventional cancer therapy efficacy decreasing adverse effects. Bioactive peptides obtained from plant animal sources have drawn increased attention because their potential as complementary This review presents contemporary...
Mesenchymal stromal cells are multipotent considered to be of great promise for use in regenerative medicine. However, the cell dose may a critical factor many clinical conditions and yield resulting from ex vivo expansion mesenchymal derived bone marrow insufficient. Thus, alternative sources need explored. In this study, were successfully isolated second trimester amniotic fluid analyzed chromosomal stability validate their safety potential utilization as therapy product.Mesenchymal...
Tumor extracellular matrix (ECM) represents a major obstacle to the diffusion of therapeutics and drug delivery systems in cancer parenchyma. This biological barrier limits efficacy promising therapeutic approaches including siRNA or agents intended for thermoablation. After extravasation due enhanced penetration retention effect tumor vasculature, typical nanotherapeutics are unable reach nonvascularized anoxic regions deep within Here, we developed simple method provide mesoporous silica...
The emerging role of humoral immunity in the pathogenesis chronic allograft damage has prompted research aimed at assessing anti-HLA antibody (Ab) monitoring as a tool to predict outcome. Data on natural history allografts children developing de novo Ab after transplantation are limited. Utilizing sera collected pretransplant, and serially posttransplant, we retrospectively evaluated 82 consecutive primary pediatric kidney recipients, without pretransplant donor-specific antibodies (DSA),...
Abstract Recent advances in the field of nanomedicine have demonstrated that biomimicry can further improve targeting properties current nanotechnologies while simultaneously enable carriers with a biological identity to better interact environment. Immune cells for example employ membrane proteins target inflamed vasculature, locally increase vascular permeability and extravasate across endothelium. Inspired by physiology immune cells, we recently developed procedure transfer leukocyte...
Cellular survival hinges on a delicate balance between accumulating damages and repair mechanisms. In this intricate equilibrium, oxidants, currently considered physiological molecules, can compromise vital cellular components, ultimately triggering cell death. On the other hand, cells possess countermeasures, such as autophagy, which degrades recycles damaged molecules organelles, restoring homeostasis. Lysosomes their enzymatic arsenal, including cathepsins, play critical roles in balance,...
Carbon nanotubes (CNTs) are allotropes of carbon, composed carbon atoms forming a tube-like structure. Their high surface area, chemical stability, and rich electronic polyaromatic structure facilitate their drug-carrying capacity. Therefore, CNTs have been intensively explored for several biomedical applications, including as potential treatment option cancer. By incorporating smart fabrication strategies, can be designed to specifically target cancer cells. This targeted drug delivery...
Abstract: A thorough understanding of interactions occurring at the interface between nanocarriers and biological systems is crucial to predict interpret their biodistribution, targeting, efficacy, thus design more effective drug delivery systems. Upon intravenous injection, nanoparticles are coated by a protein corona (PC). This confers new identity on particles that largely determines fate. Liposomes have great pharmaceutical versatility, so, as proof concept, PC has recently been...
This report describes a novel, one-pot synthesis of hybrid nanoparticles formed by nanostructured inorganic silica core and an organic pH-responsive hydrogel shell. easy-to-perform, oil-in-water emulsion process synthesizes fluorescently-doped wrapped within tunable coating cationic poly(2-diethylaminoethyl methacrylate) in one step. Transmission electron microscopy dynamic light scattering analysis demonstrated that the hydrogel-coated are uniformly dispersed aqueous phase. The formation...