A5038266125- Nanoparticle-Based Drug Delivery
- Adipose Tissue and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- Protease and Inhibitor Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Nanoplatforms for cancer theranostics
- Cardiovascular Disease and Adiposity
- Inhalation and Respiratory Drug Delivery
- Sepsis Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Antibiotics Pharmacokinetics and Efficacy
- Immune cells in cancer
- Muscle metabolism and nutrition
- Cellular transport and secretion
- Phagocytosis and Immune Regulation
Sirius University of Science and Technology
2022-2024
Biotechnology Research Center
2024
Obesity has become a pandemic, as currently more than half billion people worldwide are obese. The etiology of obesity is multifactorial, and combines contribution hereditary behavioral factors, such nutritional inadequacy, along with the influences environment reduced physical activity. Two types adipose tissue widely known white brown. While functions predominantly key energy storage, brown greater mass mitochondria expresses uncoupling protein 1 (UCP1) gene, which allows thermogenesis...
Cancer remains a significant challenge for public healthcare systems worldwide. Within the realm of cancer treatment, considerable attention is focused on understanding tumor microenvironment (TME)—the complex network non-cancerous elements surrounding tumor. Among cells in TME, tumor-associated macrophages (TAMs) play central role, traditionally categorized as pro-inflammatory M1 or anti-inflammatory M2 macrophages. M2-like TAMs can create protective environment conducive to growth and...
Proteolytic activity is pivotal in maintaining cell homeostasis and function. In pathological conditions such as cancer, it covers a key role tumor viability, spreading to distant organs, response the treatment. Endosomes represent one of major sites cellular proteolytic very often final destination internalized nanoformulations. However, little information about nanoparticle impact on biology these organelles available even though they location drug release. this work, we generated albumin...
The application of nanomedicine in the treatment acute lung injury (ALI) has great potential for development new therapeutic strategies. To gain insight into kinetics nanocarrier distribution upon time-dependent changes tissue permeability after ALI induction mice, we developed a physiologically based pharmacokinetic model albumin nanoparticles (ANP). was calibrated using data from mice treated with intraperitoneal LPS (6 mg/kg), followed by intravenous ANP (0.5 mg/mouse or about 20.8 mg/kg)...
Obesity is one of the most important health problems. Body weight can be controlled through a combination healthy diet and physical activity, but hypertrophic obesity often complicated by other comorbidities such as type 2 diabetes mellitus (T2DM), cardiovascular disease, hypertension various forms arthritis. If intense activity contraindicated for patients, then alternative approaches to combat developed. The discovery beige adipocytes in white adipose tissue has attracted attention their...