A nanoparticle-conjugated cancer drug provides a novel strategy for therapy. In this study, we manipulated nanodiamond (ND), carbon nanomaterial, to covalently link paclitaxel delivery and Paclitaxel was bound the surface of 3–5 nm sized ND through succession chemical modifications. The ND-paclitaxel conjugation measured by atomic force microscope nuclear magnetic resonance spectroscopy, confirmed with infrared spectroscopy detection deuterated paclitaxel. Treatment 0.1–50 µg ml − 1 48 h...

Diamond has received increasing attention for its promising biomedical applications. The material is highly biocompatible and can be easily conjugated with bioactive molecules. Recently, nanoscale diamond been applied as light scattering labels luminescent optical markers. luminescence, arising from photoexcitation of colour centres, substantially enhanced when type Ib nanocrystals are bombarded by a high-energy particle beam then annealed to form negatively charged nitrogen-vacancy centres....

In this paper, the origin of positive zeta potential exhibited by nanodiamond particles is explained. Positive potentials in nano-structured carbons can be explained presence graphitic planes at surface, which leave oxygen-free Lewis sites and so promotes suppression acidic functional groups. Electron Microscopy Raman Spectroscopy have been used to show that only sp2 carbon surface.

Nanodiamonds (ND) have emerged to be a widely-discussed nanomaterial for their applications in biological studies and medical diagnostics treatment. The potentials been successfully demonstrated cellular tissue models vitro. For applications, further vivo on various become important. One of the most challenging possibilities ND biomedical application is controllable drug delivery tracing. That usually assumes interaction with blood system. In this work, we study rat analyze how surface...

Ultraviolet- and visible-light-responsive titania-based photocatalysts were synthesized employed in the photocatalytic oxidation of NOx. Sol–gel processes using tetrabutyl orthotitanate ethanol under acid catalyzed condition controlled calcination performed to synthesize titanium dioxide with a mixed crystal lattice anatase, brookite rutile phases. The TiO2 prepared at 200 °C exhibited high activity for degradation NOx both ultraviolet (UV) visible-light illumination. experimental results...

We explored a very interesting gold nanoparticle system-pegylated in colloidal solution-and analyzed its uptake by mice colorectal adenocarcinoma CT26 tumor cells and the impact on cell's response to x-ray irradiation. found that exposure polyethylene glycol (PEG) modified ('pegylated') 4.7 ± 2.6 nm nanoparticles synthesized novel synchrotron-based method enhances of Transmission electron microscopy (TEM) confocal revealed substantial amounts such are taken up absorbed this conclusion is...

This work describes the chemical modification of ultradispersed nanodiamond results in enrichment surface hydroxyl groups as by FT-IR, TGA, RGA-MS and XRD measurements. These can be conveniently functionalized with long chain alcohols (oxyhexanol) for easy manipulation different functional groups. The loading oxyhexanol were found to 0.13 mmol/g nanodiamond. functionalities on modified afford a new solid phase synthesis peptides facilitate covalent attachment drug molecules. conjugation...

Recently, nanodiamond particles have attracted increasing attention as a promising nanomaterial for its biocompatibility, easy functionalization and conjugation with biomolecules, superb physical/chemical properties. Nanodiamonds are mainly used markers cell imaging, using fluorescence or Raman signals detection, carriers drug delivery. For the success of these applications, biomolecule associated has to retain functionality. In this work, protein activities egg white lysozyme adsorbed on...

The nanosized effects of short-range multimagnon excitation behavior and short-circuit diffusion in NiO nanowalls synthesized using the Ni grid thermal treatment method were observed. energy dispersive spectroscopy mapping technique was used to characterize growth mechanism, confocal Raman scattering probe antiferromagnetic exchange J2 between next-nearest-neighboring ions at various temperatures below Neel temperature. This study shows that short spin correlation leads an exponential...

We report the phonon and magnetic properties of various well-stabilized Co3O4 nanoparticles. The net valence in cobalt (II)/(III) cation can be obtained by subtracting Co2+ ions tetrahedral interstices Co3+ octahedral interstices, respectively, which will possess spatial inhomogeneity its moment via tetrahedra configurations normal spinel structure. Furthermore, distribution Co2+/Co3+ governed external (magnetic field temperature) internal (particle size slightly distorted CoO6 octahedra)...

Surface-graphitized nanodiamonds (NDs) are promising hybrid nanomaterials which appear to combine core properties of diamond with surface graphene-based materials. Here we demonstrate that NDs covered by graphene islands, so-called Fullerene-Like Reconstructions (FLRs), sensitive hole doping molecular oxygen in water. FLRs (NDs-FLRs) prepared annealing under vacuum detonation at 750 °C. We propose is promoted on due a unique electronic interaction between the and outer layer. As consequence,...

Solar ultraviolet (UV) radiation causes various deleterious effects, and UV blockage is recommended for avoiding sunburn. Nanosized titanium dioxide zinc oxide offer effective protection enhance cosmetic appearance but entail health concerns regarding their photocatalytic activity, which generates reactive oxygen species. These are absent in nanodiamonds (NDs). Among the wavelengths sunlight, UVB irradiation primarily threatens human health. The efficacy safety of NDs were evaluated using...

We investigate the antibacterial effect of ultrafine nanodiamond particles with an average size 5 nm against gram-negative bacteria Escherichia coli (E. coli). UV-visible, Raman spectroscopy, and scanning electron microscopy (SEM) have been employed to elucidate nature interaction. The influence on bacterial growth was monitored by measuring optical densities E. at 600 as a function time in presence carboxylated (cND) (100 μg/ml) highly nutritious liquid Luria–Bertani medium. SEM images...

Hybrid core-shell nanodiamond-gold nanoparticles were synthesized and characterized as a novel multifunctional material with tunable tailored properties for biomedical applications. The combination of nanostructured gold nanodiamond afford new options optical labeling, imaging, sensing, drug delivery, well targeted treatment. ND@Au composed (ND) core doped Si vacancies (SiV) Au shell in terms their Several bioimaging modalities based on the spectroscopic hybrid nano-systems are demonstrated...

Photodynamic therapy (PDT) is a well-established cancer treatment method that employs light to generate reactive oxygen species (ROS) causing oxidative damage cells. Nevertheless, PDT encounters challenges due its oxygen-dependent nature, which makes it less effective in hypoxic tumor environments. To address this issue, we have developed novel nanocomposite known as AuNC@BBR@Ghost. This combines the advantageous features of erythrocyte ghost membranes, photoresponsive properties gold...

In this work, the spectroscopic properties of surface functionalized nanodiamond particles are investigated via Fourier transform infrared spectroscopy. The functionalization was achieved chemically using strong acid treatment method. size dependent CO stretching frequency (between 1680 and 1820cm−1) studied for particle diameter sizes from 5to500nm range. frequencies at ∼1820cm−1, large (500nm), down shifted to 1725cm−1 (5nm) with decreasing sizes. We attributed shift as a result hydrogen...

The application of a nanometre-sized diamond in Raman-detectable biolabelling is demonstrated this study. interaction lysozyme–nanodiamond complex with bacteria E. coli was observed via Raman mapping using the signal as labelling marker. results are compared scanning electron microscope observations, and adsorbed lysozyme's functionality analysed. High antibacterial activity observed, equivalent to active lysozyme solution. suggest that nanodiamond can be effective it applied ambient...

In this study we analyzed the structural and electronic properties of a new morphological form, one-dimensional (1D) Ta2O5 nanorod arrays, which were synthesized by hot filament metal vapor deposition. Field-emission scanning electron microscopy (FESEM) showed 1D nanorods to be arranged in large-area high-density array about 50 nm wide approximately 550 long. X-ray photoemission spectroscopy (XPS) revealed not only structures chemical but also their stoichiometric Ta O compositions....