A5066464704- RNA Interference and Gene Delivery
- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Virus-based gene therapy research
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Mesenchymal stem cell research
- Boron Compounds in Chemistry
- Photodynamic Therapy Research Studies
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Viral gastroenteritis research and epidemiology
- Peptidase Inhibition and Analysis
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Calcium Carbonate Crystallization and Inhibition
- Pickering emulsions and particle stabilization
Saint - Petersburg State Chemical Pharmaceutical Academy
2024
First Pavlov State Medical University of St. Petersburg
2016-2024
Peter the Great St. Petersburg Polytechnic University
2017-2024
Sirius University of Science and Technology
2023-2024
Saint Petersburg Academic University
2019-2024
Russian Scientific Center of Radiology and Surgical Technologies
2019-2024
St Petersburg University
2020-2023
Federal Almazov North-West Medical Research Centre
2023
Ministry of Health of the Russian Federation
2018-2023
Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology
2020
Carefully designed micro- and nanocarriers can provide significant advantages over conventional macroscopic counterparts in drug delivery applications. For the successful of bioactive compounds, carriers should possess a high loading capacity, triggered release mechanisms, biocompatibility, biodegradability. Porous calcium carbonate (CaCO3) is one most promising platforms, which encompass all aforementioned requirements. Here, we study both formation particles biological applicability CaCO3....
The incorporation of bioactive compounds onto polymer fibrous scaffolds with further control drug release kinetics is essential to improve the functionality for personalized therapy and regenerative medicine. In this study, hybrid microcapsules were prepared used as carriers, which are deposited microfiber [polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), PHB doping conductive polyaniline (PANi) 2 wt % (PHB-PANi)]. number immobilized decreased increase in their ζ-potential due...
Conventional cancer therapy methods have serious drawbacks that are related to the nonspecific action of anticancer drugs leads high toxicity on normal cells and increases risk recurrence. The therapeutic effect can be significantly enhanced when various treatment modalities implemented. Here, we demonstrate radio- photothermal (PTT) delivered through nanocarriers (gold nanorods, Au NRs) in combination with chemotherapy a melanoma results complete tumor inhibition compared single therapy....
An important area in modern malignant tumor therapy is the optimization of antitumor drugs pharmacokinetics. The use some limited clinical practice due to their high toxicity. Therefore, strategy for optimizing drug pharmacokinetics focuses on generation local concentrations these with minimal systemic and tissue-specific This can be achieved by encapsulation highly toxic (vincristine (VCR) that 20-50 times more than widely used doxorubicin) into nano- microcarriers further association...
Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they restricted therapeutic potential. Natural drug (e.g. mesenchymal stem cells, MSCs) are able to migrate towards the tumor site penetrate cancerous cells. These biomimetic features make MSCs an attractive delivery platform that allows achieving maximal efficiency minimal toxic side effects. A combination of exhibiting a homing...
In this study, hybrid composites based on β-alloy Ti-xNb and oxide nanotubes (NTs) have been successfully prepared. NTs of different sizes were grown Ti-Nb substrates with Nb contents (5, 25, 50 wt %) via electrochemical anodization at 30 60 V. Scanning electron microscopy imaging revealed that vertically aligned nanotubular structures form the surface alloy influence content in alloys NT length. X-ray diffraction analysis confirmed formation anodized TiO2 layer several phases as increased,...
A novel protocol for topical influenza immunization is reported. CaCO 3 carriers are used to deliver vaccine into hair follicles aiming target perifollicular antigen presenting cells. This approach represents a promising alternative injections.
Reliable cell labeling and tracking techniques are imperative for elucidating the intricate ambiguous interactions between mesenchymal stromal cells (MSCs) tumors. Here, we explore fluorescent photoconvertible nanoengineered vesicles to study mMSC migration in brain These 3 μm sized made of carbon nanoparticles, Rhodamine B (RhB), polyelectrolytes readily internalized by cells. The dye undergoes photoconversion under 561 nm laser exposure with a fluorescence blue shift upon demand. optimal...
The implementation of RNAi technology into the clinical practice has been significantly postponing due to issues regarding delivery naked siRNA predominantly target cells. Here we report approach enhance efficiency by encapsulating new carrier systems which are obtained via combination widely used layer-by-layer technique and in situ modification sol-gel chemistry. We three types siRNAs (NP-717, NP-1155 NP-1496) encapsulated form as therapeutic agents against H1N1 influenza virus infection....
Growth factor incorporation in biomedical constructs for their local delivery enables specific pharmacological effects such as the induction of cell growth and differentiation. This has enabled a promising way to improve tissue regeneration process. However, it remains challenging identify an appropriate approach that provides effective loading into with following release kinetics prolonged manner. In present work, we performed systematic study, which explores optimal strategy...
Abstract All‐dielectric nanophotonics becomes a versatile tool for various optical applications, including nanothermometry and heating. Its general concept includes excitation of Mie resonances in nonplasmonic nanoparticles. However, the potential resonant dielectric nanoparticles drug delivery applications still has not been fully realized. Here, optically iron oxide (α‐Fe 2 O 3 NPs) are employed remote rupture microcontainers used as platform. It is theoretically experimentally...
Biomedical application of various nanoparticles (NPs) for bioimaging and therapeutic purposes attracts huge interest. In particular, NPs can be used as nanocarriers radionuclides radiotherapy malignant neoplasms. However, most approaches NP radiolabeling are complicated, their transfer into clinical practice is difficult due to multistep process, limited reproducibility, lack an automated procedure. Here, we develop a universal method suitable (either organic or inorganic) internal B16-F10...
mRNA-based therapeutics have been found to be a promising treatment strategy in immunotherapy, gene therapy, and cancer treatments. Effectiveness of mRNA depends on the level duration desired protein’s expression, which is determined by various cis- trans-regulatory elements mRNA. Sequences 5′ 3′ untranslated regions (UTRs) are responsible for translational efficiency stability An optimal combination regulatory sequences allows researchers significantly increase target expression. Using both...
We designed novel hybrid inorganic/organic capsules with unique physicochemical features enabling multimodal triggering by physical (UV light, ultrasound) and chemical (enzymatic treatment) stimuli. Notably, the UV- ultrasound response was achieved a synergetic combination of TiO2 SiO2 nanostructures which were in situ deposited into polymer shell microcapsules during sol-gel synthesis. This results formation composite enhanced mechanical stability. Such modification reduces permeability...