A5072406608- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Collagen: Extraction and Characterization
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Polymer Surface Interaction Studies
- Enzyme Production and Characterization
- Bone and Dental Protein Studies
- Polysaccharides Composition and Applications
- biodegradable polymer synthesis and properties
- Calcium Carbonate Crystallization and Inhibition
- Proteoglycans and glycosaminoglycans research
- Advanced Drug Delivery Systems
- Osteoarthritis Treatment and Mechanisms
- Alkaline Phosphatase Research Studies
- Nanocomposite Films for Food Packaging
- Tissue Engineering and Regenerative Medicine
- Orthopaedic implants and arthroplasty
- Endodontics and Root Canal Treatments
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Protein Hydrolysis and Bioactive Peptides
- Proteins in Food Systems
- Dental materials and restorations
Lancaster University
2017-2025
Ghent University
2010-2020
Ghent University Hospital
2016
Radboud University Nijmegen
2010-2013
Radboud University Medical Center
2012
Kiel University
2009-2010
TU Dresden
2005-2009
Max Bergmann Zentrum für Biomaterialien
2006-2007
Abstract Hydroxyapatite (HAP) and tricalcium phosphate (TCP) are two very common ceramic materials for bone replacement. However, in general HAP TCP scaffolds not tailored to the exact dimensions of defect site mainly used as granules or beads. Some available ordinary blocks, but cannot be customized individual perfect fit. Using computer‐assisted 3D printing, an emerging rapid prototyping technique, three‐dimensional can built up from powder layer by with subsequent sintering. These have...
Collagen has found use as a scaffold material for tissue engineering well coating implants with view to enhancing osseointegration through mimicry of the bone extracellular matrix in vivo. The aim this study was compare collagen types I, II, and III regard their ability bind small leucine-rich proteoglycans (SLRPs) decorin biglycan during fibrillogenesis vitro phosphate buffer. In addition, influence SLRPs on proportion molecules incorporated into fibrils at high low ionic strength...
Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability crosslink chitosan hydrogels biomedical applications. However, most studies focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified pectin (PC), bioactive glass (BG), rosmarinic acid (RA). All of these not only involved in crosslinking, but also modulated properties or imparted...
Interest is growing in the use of hydrogels as bone tissue-engineering (TE) scaffolds due to advantages such injectability and ease incorporation active substances enzymes. Hydrogels consisting gellan gum (GG), an inexpensive calcium-crosslinkable polysaccharide, have been applied cartilage TE. To improve GG suitability a material for TE, alkaline phosphatase (ALP), enzyme involved mineralization by cleaving phosphate from organic phosphate, was incorporated into induce with calcium (CaP)....
Abstract Alkaline phosphatase (ALP), an enzyme involved in mineralization of bone, is incorporated into three hydrogel biomaterials to induce their with calcium phosphate (CaP). These are collagen type I, a mussel‐protein‐inspired adhesive consisting PEG substituted catechol groups, cPEG, and the PEG/fumaric acid copolymer OPF. After incubation Ca‐GP solution, FTIR, EDS, SEM, XRD, SAED, ICP‐OES, von Kossa staining confirm CaP formation. The amount mineral formed decreases order cPEG >...
Abstract Studies in developmental and cell biology have established the fact that responses of cells are influenced to a large degree by morphology composition extracellular matrix. Goal this work is use basic principle improve biological acceptance implants modifying surfaces with components matrix (ECM), utilizing natural self‐assembly potential collagen combination further ECM close analogy situation vivo . Aiming at load‐bearing applications bone contact, type I proteoglycan decorin...
Collagen has found use as a scaffold material for tissue engineering well coating implants. The main aim of this study was to compare the ability collagen types I and II bind preparations chondroitin sulfate A−C (CS A, CS B, C). In addition, effect three on extent incorporated into fibrils morphology investigated, influence fibril coatings containing titanium surfaces adhesion primary rat osteoblasts. Fibrils both bound higher mass C than B greater A per milligram formed. type fibrils....
Hydrogels of biocompatible calcium-crosslinkable polysaccharide gellan gum (GG) were enriched with bioglass particles to enhance (i) mineralization calcium phosphate (CaP); (ii) antibacterial properties and (iii) growth bone-forming cells for future bone regeneration applications.
Mineralization of hydrogels, desirable for bone regeneration applications, may be achieved enzymatically by incorporation alkaline phosphatase (ALP). ALP-loaded gellan gum (GG) hydrogels were mineralized incubation in mineralization media containing calcium and/or magnesium glycerophosphate (CaGP, MgGP). with CaGP:MgGP concentrations 0.1:0, 0.075:0.025, 0.05:0.05, 0.025:0.075 and 0:0.1 (all values mol/dm3, denoted A, B, C, D E, respectively) compared. Mineral formation was confirmed IR...
The process of porous calcium carbonate (CaCO3 ) covering on electrospun poly(ε-caprolactone) (PCL) fibers is described in this study. Uniform CaCO3 coatings, composed vaterite microparticles and its aggregates, were formed PCL by mineral precipitation from solution under ultrasonic treatment. structure polymorphic form useful for loading various substances (drugs nanoparticles), property makes an appropriate material design drug delivery systems. Such mineralization was implemented to...
This study aimed to develop hybrid electrospun chitosan–phospholipid nanofibers and investigate the effect of phospholipid (P) content chitosans (Ch) molecular weights (Mw) degree acetylation (DA), on morphological, mechanical mucoadhesive properties nanofibers. Electrospun Ch/P exhibited a smooth uniform surface with average diameters ranging from 300 1000 nm, as observed by scanning electron microscopy (SEM). The diameter was increase Mw deacetylation Ch, content. elastic adhesive were...
Freeze–drying bigels is a novel technique for developing functional materials dermatological and cosmetic use, leveraging the benefits of two structured phases. This study optimized freeze–dried composed whey protein isolate (WPI)/sodium alginate/glycerin hydrogel ethylcellulose (EC)/Span 80/sunflower oil oleogel at varying hydrogel/oleogel ratios. The showed swelling ratios from 50% to 255%, with higher values lower content polymer concentration. extended degradation few hours 7 days....
This article reports on a study of the mineralisation behaviour CaCO3 deposited electrospun poly(ε-caprolactone) (PCL) scaffolds preliminarily treated with low-temperature plasma. work was aimed at developing an approach that improves wettability and permeability PCL in order to obtain superior composite coated highly porous CaCO3, which is prerequisite for biomedical used drug delivery. Since synthetic polymer lacks functional groups, plasma processing O2, NH3, Ar atmospheres enables...
Mineralized hydrogels are increasingly gaining attention as biomaterials for bone regeneration. The most common mineralization strategy has been addition of preformed inorganic particles during hydrogel formation. This maintains injectability. One form cement is formed by mixing the highly reactive calcium phosphate alpha-tricalcium (α-TCP) with water to hydroxyapatite (HA). ions released this reaction can be exploited crosslink anionic, calcium-binding polymers such polysaccharide gellan...
In this work, composite membranes were investigated as future components of a layered implant for the reconstruction nasal septum. Incorporation zinc ions into implants could potentially provide antibacterial properties to decrease or eliminate bacterial infections and subsequent surgical complications. Two types prepared using an electrospinning method: PCL with bioglass doped Zn. The aim work was investigate influence addition on morphology, fiber diameter composition membranes....