A5079590307- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Additive Manufacturing and 3D Printing Technologies
- Graphene and Nanomaterials Applications
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Pickering emulsions and particle stabilization
- Polymer Surface Interaction Studies
- Advanced Cellulose Research Studies
- Advanced Materials and Mechanics
- Dental Implant Techniques and Outcomes
- Anatomy and Medical Technology
- Advanced Drug Delivery Systems
- Hernia repair and management
- Muscle metabolism and nutrition
- Proteins in Food Systems
- Soil Management and Crop Yield
- Diamond and Carbon-based Materials Research
- Laser-Ablation Synthesis of Nanoparticles
- Nanocomposite Films for Food Packaging
- Skin Protection and Aging
- Solar-Powered Water Purification Methods
- Innovations in Concrete and Construction Materials
Universitatea Națională de Știință și Tehnologie Politehnica București
2015-2024
University of Bucharest
2015-2024
The development of materials for 3D printing adapted tissue engineering represents one the main concerns nowadays. Our aim was to obtain suitable 3D-printed scaffolds based on methacrylated gelatin (GelMA). In this respect, three degrees GelMA methacrylation, different concentrations (10%, 20%, and 30%), also two photoinitiator (I-2959) (0.5% 1%) were explored develop proper hydrogel ink formulations be used in process. Afterward, all these hydrogel-based inks/3D-printed characterized...
Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability crosslink chitosan hydrogels biomedical applications. However, most studies focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified pectin (PC), bioactive glass (BG), rosmarinic acid (RA). All of these not only involved in crosslinking, but also modulated properties or imparted...
Network-forming polymerization of methacrylamide gelatin and acrylamide generates scaffolds with controlled biocompatibility water affinity.
Manufacturing of three-dimensional scaffolds with multiple levels porosity are an advantage in tissue regeneration approaches to influence cell behavior. Three-dimensional surface roughness and intra-filament open were successfully fabricated by additive manufacturing combined chemical foaming porogen leaching without the need toxic solvents. The decomposition sodium citrate, a blowing agent, generated pores within scaffold filaments, which interconnected opened external environment...
This work reports the development of a marine-derived polysaccharide formulation based on k-Carrageenan and sodium alginate in order to produce novel scaffold for engineering applications. The viscoelastic properties bicomponent inks were assessed via rheological tests prior 3D printing. Compositions with different weight ratios between two polymers, without any crosslinker, subjected printing first time, best our knowledge, fabrication parameters optimized ensure controlled architecture....
This work proposes a simple method to obtain nanostructured hydrogels with improved mechanical characteristics and relevant antibacterial behavior for applications in articular cartilage regeneration repair. Low amounts of silver-decorated carbon-nanotubes (Ag@CNTs) were used as reinforcing agents the semi-interpenetrating polymer network, consisting linear polyacrylamide (PAAm) embedded PAAm-methylene-bis-acrylamide (MBA) hydrogel. The rational design materials considered specific purpose...
Three-dimensional (3D) printing technology was able to generate great attention because of its unique methodology and for major potential manufacture detailed customizable scaffolds in terms size, shape pore structure fields like medicine, pharmaceutics food. This study aims fabricate an ink entirely composed natural polymers, alginate, k-carrageenan carboxymethyl cellulose (AkCMC). Extrusion-based 3D used obtain based on a crosslinked interpenetrating polymer network from the k-carrageenan,...
This work explores novel biocomposite hydrogels fabricated using 40% (wt/vol) solution of whey protein isolate (WPI, from the food industry) mixed with increasing concentrations synthetic aragonite rod-like powder 0, 100, 200 and 300 mg/ml (named WPI0, WPI100, WPI200 WPI300). FTIR results showed that was successfully incorporated into WPI hydrogel network. SEM micro-CT investigations revealed mainly concentrated near edges composite samples, except in WPI300, which had homogeneous...
The present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. biopolymeric matrix consisted methacrylated gelatin (GelMA). Several types nanoclay were added as inorganic component. Our aim was to investigate influence clay type on rheological behavior ink formulations and determine morphological structural properties resulting crosslinked hydrogel-based nanomaterials. Moreover, through inclusion nanoclays, our goal...
Over the years, natural-based scaffolds have presented impressive results for bone tissue engineering (BTE) application. Further, outstanding interactions been observed during interaction of graphene oxide (GO)-reinforced biomaterials with both specific cell cultures and injured in vivo experimental conditions. This research hereby addresses potential fish gelatin/chitosan (GCs) hybrids reinforced GO to support vitro osteogenic differentiation and, further, investigate its behavior when...
In the actual context of growing concerns over sustainability and energy efficiency, Phase Change Materials (PCMs) have gained attention as promising solutions for enhancing storage release efficiency. On another hand, materials based on graphene oxide (GO) proven antibacterial activity, biocompatibility, efficiency in microbial growth inhibition, pollutant removal. Integrating nanoparticles into PCMs creating Nano-Enhanced (NEPCMs) opened new horizons optimizing performance these systems...
Due to the reduced ability of most harmed tissues self-regenerate, new strategies are being developed in order promote self-repair assisted or not by biomaterials, among these tissue engineering (TE). Human adipose-derived mesenchymal stem cells (hASCs) currently represent a promising tool for reconstruction, due their low immunogenicity, high differentiation potential multiple cell types and easy harvesting. Gelatin is natural biocompatible polymer used regenerative applications, while...
Biocompatibility, biodegradability, shear tinning behavior, quick gelation and an easy crosslinking process makes alginate one of the most studied polysaccharides in field regenerative medicine. The main purpose this study was to obtain tissue-like materials suitable for use bone regeneration. In respect, several types clay were investigated as components 3D-printing, nanocomposite inks. Using extrusion-based nozzle, nanocomposites inks printed 3D multilayered scaffolds. To observe behavior...
The present research work is focused on the design and investigation of electrospun composite membranes based citric acid-functionalized chitosan (CsA) containing reduced graphene oxide-tetraethylene pentamine (CsA/rGO-TEPA) as materials with opportune bio-properties for applications in wound dressings. covalent functionalization (CS) acid (CA) was achieved through EDC/NHS coupling system checked by 1H-NMR spectroscopy FTIR spectrometry. mixtures to be were formulated adding three...
As bone diseases and defects are constantly increasing, the improvement of regeneration techniques is evolving. The main purpose this scientific study was to obtain investigate biomaterials that can be used in tissue engineering. In respect, nanocomposite inks GelMA modified with hydroxyapatite (HA) substituted Mg Zn were developed. Using a 3D bioprinting technique, scaffolds varying shapes dimensions obtained. following analyses order materials obtained by printing technique: Fourier...
Salecan, a kind of polysaccharide, is produced by the Agrobacterium ZX09 salt tolerant strain. In this study, green crosslinked citric acid-salecan hydrogels are explored as novel materials with high potential for use in regenerative medicine. The impact salecan and acid on final was intensively studied estimated terms whole physicochemical properties antimicrobial activity. FTIR spectra demonstrated successful crosslinking through its esterification where formation strong covalent bonds...
The advent of 3D printing technology has enabled the engineering bone tissue for patient-specific healing and fabrication in vitro models ex vivo testing.
The main drawback regarding hydrogels utilization in biomedical engineering is represented by their weak mechanical properties and it often addressed either using nanospecies as fillers or generating secondary networks that strengthen the material. Our study validates a new synthesis route of obtaining double-network nanostructured materials making use functional groups an adsorbed glyco-protein on carbon-based nanospecies. Following simple procedure, decorated were embedded synthetic...
Considering the potential of hydrogels to mimic cellular microenvironment, methacryloyl gelatin (GelMA) and mucin (MuMA) were selected compared as bioinspired coatings for commercially available polypropylene (PP) meshes ventral hernia repair. Thin, elastic hydrated hydrogel layers obtained through network-forming photo-polymerization, after immobilization derivatives on surface PP fibers. Fourier transform infrared spectroscopy (FTIR) proved successful coating while morphology homogeneity...
This study deals with the design and comprehensive evaluation of novel hydrogels based on whey protein isolate (WPI) for tissue regeneration. So far, WPI has been considered mainly as a food industry by-product there are very few reports application in engineering (TE). In this work, WPI-based were modified bioactive glass (BG), which is commonly used bone substitute material. Ready-to-use, sterile produced by simple technique, namely heat-induced gelation. Two different concentrations (10...
Fabrication of three-dimensional (3D) scaffolds using natural biomaterials introduces valuable opportunities in bone tissue reconstruction and regeneration. The current study aimed at the development paste-like 3D printing inks with an extracellular matrix-inspired formulation based on marine materials: sodium alginate (SA), cuttlebone (CB), fish gelatin (FG). Macroporous microporous biocomposite filaments were obtained by combined post-printing crosslinking. CB fragments used for their...