A5046171271- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Wound Healing and Treatments
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Polysaccharides Composition and Applications
- Laser Applications in Dentistry and Medicine
- Nanocomposite Films for Food Packaging
- Surgical Sutures and Adhesives
- Polysaccharides and Plant Cell Walls
- Collagen: Extraction and Characterization
Universitatea Națională de Știință și Tehnologie Politehnica București
2021-2023
National Research & Development Institute for Textiles and Leather
2023
The development of materials for 3D printing adapted tissue engineering represents one the main concerns nowadays. Our aim was to obtain suitable 3D-printed scaffolds based on methacrylated gelatin (GelMA). In this respect, three degrees GelMA methacrylation, different concentrations (10%, 20%, and 30%), also two photoinitiator (I-2959) (0.5% 1%) were explored develop proper hydrogel ink formulations be used in process. Afterward, all these hydrogel-based inks/3D-printed characterized...
The main objective was to produce 3D printable hydrogels based on GelMA and hydroxyapatite doped with cerium ions potential application in bone regeneration. first part of the study regards substitution Ca
Dressing biomaterials play a key role in wound management keeping moisture medium and protecting against external factors. Natural synthetic materials could be used as dressings where chitosan bacterial cellulose is one of the most important solutions. These biopolymers have been for dressing based on their non-toxic, biodegradable, biocompatible features. In this study, biocomposites membranes tailored with antimicrobial loaded poly(N-isopropylacrylamide)/polyvinyl alcohol nanoparticles...
The present study investigated the possibility of obtaining 3D printed composite constructs using biomaterial-based nanocomposite inks. biopolymeric matrix consisted methacrylated gelatin (GelMA). Several types nanoclay were added as inorganic component. Our aim was to investigate influence clay type on rheological behavior ink formulations and determine morphological structural properties resulting crosslinked hydrogel-based nanomaterials. Moreover, through inclusion nanoclays, our goal...
Biocompatibility, biodegradability, shear tinning behavior, quick gelation and an easy crosslinking process makes alginate one of the most studied polysaccharides in field regenerative medicine. The main purpose this study was to obtain tissue-like materials suitable for use bone regeneration. In respect, several types clay were investigated as components 3D-printing, nanocomposite inks. Using extrusion-based nozzle, nanocomposites inks printed 3D multilayered scaffolds. To observe behavior...
The fabrication of collagen-based biomaterials for skin regeneration offers various challenges tissue engineers. purpose this study was to obtain a novel series composite based on collagen and several types clays. In order investigate the influence clay type drug release behavior, obtained materials were further loaded with gentamicin. Physiochemical biological analyses performed analyze nanocomposite after nanoclay embedding. Infrared spectra confirmed inclusion in polymeric matrix without...
As bone diseases and defects are constantly increasing, the improvement of regeneration techniques is evolving. The main purpose this scientific study was to obtain investigate biomaterials that can be used in tissue engineering. In respect, nanocomposite inks GelMA modified with hydroxyapatite (HA) substituted Mg Zn were developed. Using a 3D bioprinting technique, scaffolds varying shapes dimensions obtained. following analyses order materials obtained by printing technique: Fourier...
Salecan, a kind of polysaccharide, is produced by the Agrobacterium ZX09 salt tolerant strain. In this study, green crosslinked citric acid-salecan hydrogels are explored as novel materials with high potential for use in regenerative medicine. The impact salecan and acid on final was intensively studied estimated terms whole physicochemical properties antimicrobial activity. FTIR spectra demonstrated successful crosslinking through its esterification where formation strong covalent bonds...
A multitude of dressings have been developed to promote wound repair, such as membranes, foams, hydrocolloids and hydrogels. In this study, a crosslinked polysaccharide hydrogel was mixed with bioactive ingredient synthesize novel nanocomposite material be used in healing. Variation the ratio between components followed its effect analyzed regard swelling, degradation rate thermo-mechanical behavior. The resulting structures were characterized by FTIR microscopy analyses. antimicrobial...
Natural polysaccharides are highly attractive biopolymers recommended for medical applications due to their low cytotoxicity and hydrophilicity. Polysaccharides derivatives also suitable additive manufacturing, a process in which various customized geometries of 3D structures/scaffolds can be achieved. Polysaccharide-based hydrogel materials widely used printing tissue substitutes. In this context, our goal was obtain printable nanocomposites by adding silica nanoparticles microbial...
The main objective of the present work was to produce three-dimensional (3D)- printable nanocomposite hydrogels based on two kinds marine-sourced polysaccharides doped with nanoclay potential biomedical application. First part research study investigated preparation polysaccharide bicomponent hydrogel formulations followed by selection optimal ratio concentrations which ensured proper morphostructural stability 3D-printed constructs. Second step aimed generate 3D scaffolds high printing...