The concept of PLGA-lipid hybrid nanoparticles arose as a motivation for developing drug delivery systems with versatile physical and chemical properties, unequivocal therapeutic benefits minimized side effects. These formulations opened new avenue "smart tools" in the development personalized, noninvasive emerging nanomedicine. However, there is still risk that smart system manufactured from mixture materials, such PLGA combination synthetic/vegetable lipids targeting agents might trigger...

The development of materials for 3D printing adapted tissue engineering represents one the main concerns nowadays. Our aim was to obtain suitable 3D-printed scaffolds based on methacrylated gelatin (GelMA). In this respect, three degrees GelMA methacrylation, different concentrations (10%, 20%, and 30%), also two photoinitiator (I-2959) (0.5% 1%) were explored develop proper hydrogel ink formulations be used in process. Afterward, all these hydrogel-based inks/3D-printed characterized...

Dressing biomaterials play a key role in wound management keeping moisture medium and protecting against external factors. Natural synthetic materials could be used as dressings where chitosan bacterial cellulose is one of the most important solutions. These biopolymers have been for dressing based on their non-toxic, biodegradable, biocompatible features. In this study, biocomposites membranes tailored with antimicrobial loaded poly(N-isopropylacrylamide)/polyvinyl alcohol nanoparticles...

The need for solutions in the pharmaceutical field that respond to new needs regarding minimum impact of active substances on body has led an explosion research smart systems controlled drug delivery. Supramolecular chemistry provided recent years powerful tools synthesis these forms release, cyclodextrins offering possibility complex supramolecular architectures meet requirements. But can be used only with a carrier order benefit by their excellent properties and this review presents latest...

The purpose of this work was to more exhaustively study the influence nanocarrier matrix composition and also polyethylene glycol (PEG)-modified surface on performances formulations as lipophilic drug delivery systems. Poly (d,l-lactide-co-glycolide), two vegetable oils (Nigella sativa oil Echium oil) indomethacin were employed prepare novel PEG-coated nanocarriers through emulsion solvent evaporation method. modification achieved by physical PEG adsorption (in post-production step)....

The present research work is focused on the design and investigation of electrospun composite membranes based citric acid-functionalized chitosan (CsA) containing reduced graphene oxide-tetraethylene pentamine (CsA/rGO-TEPA) as materials with opportune bio-properties for applications in wound dressings. covalent functionalization (CS) acid (CA) was achieved through EDC/NHS coupling system checked by 1H-NMR spectroscopy FTIR spectrometry. mixtures to be were formulated adding three...

This research study reports the development of chitosan/carboxylated graphene oxide (CS/GO-COOH) composite scaffolds with nanofibrous architecture using electrospinning method. The concept designed fibrous material is based on bringing together biological properties CS, mechanical, electrical, and characteristics GO-COOH versatility efficiency ultra-modern techniques. Three different concentrations were added into a chitosan (CS)-poly(ethylene oxide) (PEO) solution (the ratio between CS/PEO...

Rapid developing antimicrobial resistance due to broad antibiotic utilisation in healthcare and food industries the non-availability of novel antibiotics represents one most critical public health issues worldwide. The current advances nanotechnology allow new materials address drug-resistant bacterial infections specific, focused biologically safe ways. unique physicochemical properties, biocompatibility, wide range adaptability nanomaterials that exhibit photothermal capability can be...

This work reports the construction of a bicomponent scaffold co-loaded with both prodrug and drug (BiFp@Ht) as an efficient platform for wound dressing, by combining electrospinning 3D-printing technologies. The outer component consisted chitosan/polyethylene oxide-electrospun membrane loaded indomethacin–polyethylene glycol–indomethacin (Fp) served support printing inner component, gelatin methacryloyl/sodium alginate hydrogel tetracycline hydrochloride (Ht). different architectural...

The main drawback regarding hydrogels utilization in biomedical engineering is represented by their weak mechanical properties and it often addressed either using nanospecies as fillers or generating secondary networks that strengthen the material. Our study validates a new synthesis route of obtaining double-network nanostructured materials making use functional groups an adsorbed glyco-protein on carbon-based nanospecies. Following simple procedure, decorated were embedded synthetic...

The current research study deals with the design and investigation of novel bioinspired biocompatible GO-COOH decorated hybrid polymeric scaffolds nanofibrous architecture as biomaterials highly appropriate features for functional restoration damaged tissue. Gelatin alginate, two biobased-polymers excellent biocompatibility, high microenvironment biomimicry ability proper guidance cell development in combination carboxylated graphene oxide (GO-COOH), embody matrix electrospun scaffolds....

The paper addresses the synthesis of a nano-fibre network by coaxial electrospinning, embedding healing agent dicyclopentadiene (DCPD) in polyacrylonitrile (PAN) fibres. Compared to other encapsulation methods, use nano-fibres filled with have no effect on mechanical properties matrix and can address larger area. Additionally, carbon nanotubes were added as nanofillers enhance reactivity between DCPD epoxydic matrix. self-healing capability was carried out flexural tests, at epoxy resin...

Due to environmental concerns, as well its exceptional physical and mechanical capabilities, biodegradability, optical barrier qualities, nanocellulose has drawn a lot of interest source reinforcing materials that are nanometer sized. This article focuses on how manufacture cellulose nanomaterials from cotton by using different types acids such H2SO4 HCI in concentrations the presence enzymes cellulase xylanase. Two bleaching methods were used before acid enzyme hydrolysis. In first method,...

The tremendous technological and dental material progress led to a progressive advancement of treatment technologies materials in restorative dentistry prosthodontics. In this approach, CAD/CAM restorations have proven be valuable both provisional definitive restoration, owing multifarious design, improved highly tunable mechanical, physical morphological properties. Thus far, the market offers wide range with sophisticated design proper characteristics for particular clinical problem or...

Mucin is a glycoprotein with proven potential in the biomaterials field, but its use still underexploited for such applications. The present work aims to produce synthesis of methacryloyl mucin single-network (SN) hydrogels and their double-cross-linked-network (DCN) counterparts. Following derivative, various SN are prepared through photopolymerization methacrylate bonds, using reaction media different pH values. converted into DCN systems via supplementary cross-linking tannic acid aqueous...

We report the synthesis of sesamol-based polyethyleneimine (PEI) polybenzoxazines. Their physico-chemical features have been compared with other aliphatic diamine chains and influence on thermo-mechanical properties phenol substituent was investigated. molecular structures were checked through Fourier Transform Infrared Spectroscopy (FT-IR) nuclear magnetic resonance (1H NMR 13C NMR) spectrometry. Differential scanning calorimetry (DSC) revealed that curing process takes place in two stages...

Type II collagen has been perceived as the indispensable element and plays a crucial role in cartilage tissue engineering. Thus, materials based on type have drawn farther attention both academic research for developing new systems regeneration. The disadvantage of using biomaterial repairing is its reduced biomechanical properties. This can be solved by physical, enzymatic or chemical cross-linking processes, which provide biomaterials with required mechanical properties medical...

Although widely used as implantable materials due to their mechanical properties, metal devices show several disadvantages, such the lack of cellular binding sites, antibacterial or lubricant properties. To this end, development engineered surfaces through protein coatings has been largely investigated. Due natural origin and complex structure which allows formation hydrogels, mucins have proposed investigated effective for metallic implants. The present study evaluates ability porcine...

We designed graphene oxide composites with increased morphological and structural variability using fatty acid-coupled polysaccharide co-polymer as the continuous phase. The matrix was synthesized by N, O-acylation of chitosan palmitic lauric acid. obtained crosslinked genipin composited oxide. FTIR spectra highlighted modification multi-components interaction. DLS, SEM, contact angle tests demonstrated that conjugation hydrophobic molecules to surface roughness hydrophilicity, since it...