A5081773750- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Prion Diseases and Protein Misfolding
- 3D Printing in Biomedical Research
- Congenital Anomalies and Fetal Surgery
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- MicroRNA in disease regulation
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Marine Sponges and Natural Products
- Electrospun Nanofibers in Biomedical Applications
- Retinal Development and Disorders
- Autophagy in Disease and Therapy
University of Turin
2016-2025
Neuroscience Institute
2015-2024
Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta
2018
Zero to Three
2009
Accademia Albertina delle Belle Arti
2005
Abstract Advanced therapies which combine cells with biomaterial-based carriers are recognized as an emerging and powerful method to treat challenging diseases, such spinal cord injury (SCI). By enhancing transplanted cell survival grafting, biomimetic hydrogels can be properly engineered encapsulate locate them at the injured site in a minimally invasive way. In this work, chitosan (CS) based were developed host mesenchymal stem (MSCs), since their paracrine action therapeutically enhance...
Research Article20 November 2015Open Access Source Data Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice Marta Valenza Department of BioSciences, Centre for Stem Cell Research, Università degli Studi di Milano, Milan, Italy Search more papers by this author Jane Y Chen Intellectual Developmental Disabilities Center, Semel Institute Neuroscience, Brain Institute, David Geffen School Medicine, University California Los Angeles, CA, USA...
Spinal muscular atrophy (SMA) is a severe neuromuscular disease, the most common in infancy, and third one among young people under 18 years. The major pathological landmark of SMA selective degeneration lower motor neurons, resulting progressive skeletal muscle denervation, atrophy, paralysis. Recently, it has been shown that specific or general changes activity ribonucleoprotein containing micro RNAs (miRNAs) play role development SMA. Additionally miRNA-206 to be required for efficient...
Summary Amyloid‐β 1‐42 accumulation is the major pathogenetic event in Alzheimer’s disease (AD), believed to be responsible for synaptic dysfunction and neuronal cell death. However, physiologic activity of Aβ peptides remains elusive: might not only play a toxic role, but also act as functional signaling intermediate. We recently reported that Aβ1‐42 promotes BACE1 transcription through activation JNK‐c‐jun pathway. Here, we show Aβ1‐42‐mediated increase expression accompanied by decrease...
Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, death. Abnormalities at neuromuscular junction (NMJ) have been reported SMA, including neurofilament (NF) accumulation presynaptic terminals, immature and smaller than normal endplates, reduced transmitter release, finally, denervation. Here we studied role of agrin SMAΔ7 mice, experimental model...
Loss of the survival motor neuron gene (SMN1) is responsible for spinal muscular atrophy (SMA), most common inherited cause infant mortality. Even though SMA phenotype traditionally considered as related to loss, it remains debated whether specific targeting neurons could represent best therapeutic option disease. We here investigated, using stereological quantification methods, cord and cerebral cortex ∆7 mice during development, verify extent selectivity loss. found progressive post-natal...
Abstract Spinal muscular atrophy (SMA) is a recessive autosomal neuromuscular disease, due to homozygous mutations or deletions in the telomeric survival motoneuron gene 1 ( SMN1 ). SMA characterized by motor impairment, muscle atrophy, and premature death following neuron (MN) degeneration. Emerging evidence suggests that dysregulation of autophagy contributes MN We here investigated role SMNdelta7 mouse model II (intermediate form disease) which leads impairment postnatal day 5 (P5) P13....
Abstract The small-GTPase Rac1 is a key molecular regulator linking extracellular signals to actin cytoskeleton dynamics. Loss-of-function mutations in RAC1 and other genes of the Rac signaling pathway have been implicated pathogenesis Intellectual Disability (ID). activity negatively controlled by GAP proteins, however effect hyperactivity on neuronal networking vivo has poorly studied. ArhGAP15 Rac-specific negative regulator, expressed main subtypes pyramidal cortical neurons. In absence...
Huntington disease (HD) is an inherited late-onset neurological disorder characterized by progressive neuronal loss and disruption of cortical basal ganglia circuits. Cell replacement using human embryonic stem cells may offer the opportunity to repair damaged circuits significantly ameliorate conditions. Here, we showed that in-vitro-differentiated striatal progenitors undergo maturation integrate into host upon intra-striatal transplantation in a rat model HD. By combining graft-specific...
Spinal Muscular Atrophy (SMA) is an autosomal-recessive neuromuscular disease affecting children. It caused by the mutation or deletion of survival motor neuron 1 (SMN1) gene resulting in lower (MN) degeneration followed impairment, progressive skeletal muscle paralysis and respiratory failure. In addition to already existing therapies, a possible combinatorial strategy could be represented use adipose-derived mesenchymal stem cells (ASCs) that can obtained easily large amounts from adipose...
Major depressive disorder and bipolar disorders are prevalent mental health conditions that significantly impact quality of life expectancy. These mood involve major episodes (MDE), which pose a substantial burden for patients their families. While psychopharmacological therapies first-line treatment MDE, the response is often incomplete. New approaches focused on human-nature relationship may potentially complement antidepressant treatments, thus reducing needs. This study aims to evaluate...
'Timorasso' is an autochthonous, non-aromatic white grape variety cultivated mainly in the southwest of Piedmont region (northwestern Italy). The sensory profile wines produced from this evolves greatly with aging. In study, 31 2015-2021 vintages were analyzed to investigate changes descriptors at various stages aging and their correlation physicochemical properties (wine basic parameters, color, total polyphenols) sensory-perceptual typicity. A analysis was conducted by a panel experts, who...
Urinary incontinence, defined as the complaint of any involuntary loss urine, is a pathological condition, which affects 30% females and 15% males over 60, often following progressive decrease rhabdosphincter cells due to increasing age or secondary damage pelvic floor musculature, connective tissue and/or nerves. Recently, stem cell therapy has been proposed source for replacement trophic support sphincter. To develop new therapeutic strategies urinary we studied interaction between...
Abstract Stem cells are emerging as a therapeutic option for incurable diseases, such Amyotrophic Lateral Sclerosis (ALS). However, critical issues related to their origin well the need deepen our knowledge of actions exerted by these cells. Here, we investigate potential clinical-grade human neural stem (hNSCs) that have been successfully used in recently concluded phase I clinical trial ALS patients (NCT01640067). The hNSCs were transplanted bilaterally into anterior horns lumbar spinal...