A5046416674- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Synthesis and biological activity
- Intraoperative Neuromonitoring and Anesthetic Effects
- Inflammatory mediators and NSAID effects
- Regulation of Appetite and Obesity
- Genetics and Neurodevelopmental Disorders
- Estrogen and related hormone effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Multiple Sclerosis Research Studies
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Cell Image Analysis Techniques
- Immune Response and Inflammation
- Nuclear Receptors and Signaling
Vita-Salute San Raffaele University
2018-2024
University of Milano-Bicocca
2019-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2023
IRCCS Ospedale San Raffaele
2023
Neuroscience Institute
2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2018-2021
San Raffaele University of Rome
2019-2021
Institute of Molecular Bioimaging and Physiology
2019
Aging is associated with an exaggerated response to peripheral inflammatory challenges together behavioral and cognitive deficits. Studies considering both age sex remain limited, despite dimorphism of astrocytes microglial cells largely recognized. To fill this knowledge gap, we investigated the effect a single intraperitoneal lipopolysaccharide (LPS) administration in adult aged mice. We assessed expression different mediators, through binding [18F]-VC701 tracer translocator protein (TSPO)...
The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation and driving clinical progression multiple sclerosis (MS) is gaining scientific interest. We applied a single transcription factor (SOX10)-based protocol to accelerate oligodendrocyte differentiation from human induced pluripotent stem cell (hiPSC)-derived neural precursor cells, generating self-organizing forebrain organoids. These organoids include neurons, astrocytes, oligodendroglia, hiPSC-derived...
Huntington disease (HD) is an inherited late-onset neurological disorder characterized by progressive neuronal loss and disruption of cortical basal ganglia circuits. Cell replacement using human embryonic stem cells may offer the opportunity to repair damaged circuits significantly ameliorate conditions. Here, we showed that in-vitro-differentiated striatal progenitors undergo maturation integrate into host upon intra-striatal transplantation in a rat model HD. By combining graft-specific...
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) and appearance α-synuclein insoluble aggregates known as Lewy bodies. Neurodegeneration accompanied neuroinflammation mediated cytokines chemokines produced activated microglia. Several studies demonstrated that such an inflammatory process early event, contributes to oxidative stress mitochondrial dysfunctions. fibrillization aggregation activate microglia contribute onset...
Positron emission tomography (PET) using translocator protein (TSPO) ligands has been used to detect neuroinflammatory processes in neurological disorders, including multiple sclerosis (MS). The aim of this study was evaluate neuroinflammation a mouse MS model (EAE) TSPO-PET with 18F-VC701, combination magnetic resonance imaging (MRI).MOG35-55/CFA and pertussis toxin protocol induce EAE C57BL/6 mice. Disease progression monitored daily, whereas MRI evaluation performed at 1, 2, 4 weeks...
The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation and driving clinical progression multiple sclerosis (MS) is gaining scientific interest. We applied a single transcription factor (
Obesity is a chronic, complex pathology associated with risk of developing secondary pathologies, including cardiovascular diseases, cancer, type 2 diabetes (T2DM) and musculoskeletal disorders. Since skeletal muscle accounts for more than 70% total glucose disposal, metabolic alterations are strictly the onset insulin resistance T2DM. The present study relies on proteomic analysis gastrocnemius from 15 male female C56BL/J mice fed 14 weeks standard, 45% or 60% high-fat diets (HFD) adopting...
Abstract Background One intrastriatal administration of quinolinic acid (QA) in rats induces a lesion with features resembling those observed Huntington’s disease. Our aim is to evaluate the effects cysteinyl leukotriene receptor antagonist montelukast (MLK), which exhibited neuroprotection different preclinical models neurodegeneration, on QA-induced neuroinflammation and regional metabolic functions. Methods The right left striatum Sprague Dawley athymic nude were injected QA vehicle...
The G2019S mutation of LRRK2 represents a risk factor for idiopathic Parkinson's disease. Here, we investigate whether kinase activity regulates susceptibility to the environmental toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). knock-in mice (bearing enhanced activity) showed greater nigro-striatal degeneration compared knock-out, kinase-dead and wild-type following subacute MPTP treatment. inhibitors PF-06447475 MLi-2, tested under preventive or therapeutic treatments, protected...
Mutations in the RAB39B gene cause X-linked intellectual disability (XLID), comorbid with autism spectrum disorders or early Parkinson's disease. One of functions neuronal small GTPase is to drive GluA2/GluA3 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) maturation and trafficking, determining AMPAR subunit composition at glutamatergic postsynaptic terminals. Taking advantage Rab39b knockout murine model, we show that a lack affects dendritic spine refinement,...
Abstract We examined effects of exposing female and male mice for 33 weeks to 45% or 60% high fat diet (HFD). Males fed with either were more vulnerable than females, displaying higher faster increase in body weight elevated cholesterol liver enzymes levels. Higher glucose metabolism was revealed by PET the olfactory bulbs both sexes. However, males also displayed altered anterior cortex cerebellum metabolism, accompanied a prominent brain inflammation relative females. Although sexes...
Cyclooxygenase-2 <?tex id="Q1" staff-cmt="Please check whether the affiliations are displayed correctly."?>(COX-2) is involved in inflammatory response, and its recurrent overexpression cancers as well neurodegenerative disorders has made it an important target for therapy. For this reason, noninvasive imaging of COX-2 expression may represent diagnostic tool. In work, a inhibitor analogue, VA426 [1-(4-fluorophenyl)-3-(2-methoxyethyl)-2-methyl-5-(4-(methylsulfonil)phenyl)-1 H -pyrrole], was...