A5020827838- Metal complexes synthesis and properties
- Synthesis and biological activity
- Crystallization and Solubility Studies
- Crystal structures of chemical compounds
- X-ray Diffraction in Crystallography
- Magnetism in coordination complexes
- Synthesis and Biological Evaluation
- Metal-Catalyzed Oxygenation Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Organometallic Complex Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Click Chemistry and Applications
- Ferrocene Chemistry and Applications
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Trace Elements in Health
- Inorganic and Organometallic Chemistry
- Molecular Sensors and Ion Detection
- Research on Leishmaniasis Studies
- Synthesis and characterization of novel inorganic/organometallic compounds
- DNA and Nucleic Acid Chemistry
- Free Radicals and Antioxidants
- Bacterial biofilms and quorum sensing
Technological University Dublin
2016-2025
National University of Ireland, Maynooth
1996-2012
Université Paris Cité
2011
Centre National de la Recherche Scientifique
2011
Délégation Paris 5
2011
Tallaght University Hospital
2006
St Patrick's College
1996
Queen's University Belfast
1996
Trinity College Dublin
1991
Trinity College
1991
The complexes [Cu(salH)(2)(H(2)O)] (1), [Cu(dipsH)(2)(H(2)O)] (2), {Cu(3-MeOsal)(H(2)O)(0.75)}(n) (3), [Cu(dipsH)(2)(BZDH)(2)] (4), [Cu(dipsH)(2)(2-MeOHBZDH)(2)]·EtOH (5), [Cu(sal)(phen)] (6), [Cu(dips)(phen)]·H(2)O (7), and [Cu(3-MeOsal)(phen)]·H(2)O (8) (salH(2) = salicylic acid; dipsH(2) 3,5-diisopropylsalicylic 3-MeOsalH(2) 3-methoxysalicylic BZDH benzimidazole; 2-MeOHBZDH 2 methanolbenzimidazole phen =1,10-phenanthroline) were prepared characterized. Structures of 4, 5, 8 determined by...
Three, structurally characterised, bis-phen Cu(II) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range epithelial tumour cells. The induce relaxation supercoiled plasmid DNA absence external reducing agents and efficient CT-DNA, Poly[d(A-T)](2) Poly[d(G-C)](2) binding.
Abstract 1,10-Phenanthroline (phen, 5), 1,10-phenanthroline-5,6-dione (phendione, 6), [Cu(phendione)3](ClO4)2·4H2O (12) and [Ag(phendione)2]ClO4 (13) are highly active, in vitro, against a range of normal cancerous mammalian cells, fungal insect cell lines, with the metal complexes offering clear enhancement activity. Cytoselectivity was not observed between tumorigenic non-tumorigenic lines. In vivo tests, using Galleria mellonella Swiss mice, all four compounds were well tolerated...
Dinuclear Cu2+ and Mn2+ bis-phenanthroline octanedioate compounds exhibit rapid, unprecedented nano picomolar in vitro cytotoxicity against human-derived colorectal cancer lines (HT29, SW480 SW620) are less cytotoxic toward non-cancerous normal human keratinocyte cells (HaCaT). Both complexes displayed greater vivo drug tolerance compared to cisplatin when examined using the insect Galleria mellonella. The potent generators of intracellular reactive oxygen species within HT29 cells, display...
Metal complexes of malonie acid (metal = Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Ag(I)) were prepared and only the Ag(I) complex inhibited growth Candida albicans . Malonate incorporating chelating 1,10‐phenanthroline (1,10‐phen) ligand showed a range activities: good (Mn(II), Ag(I)); moderate (Zn(II)); poor (Co(II), Ni(II)). Metal‐free 1,10‐phen Ag(CH 3 CO 2 ) also highly active. The metal‐free non‐chelating ligands 1,7‐ phenanthroline 4,7‐phenanthroline inactive Mn(II) Zn(II) complexs...
The coordination modes of copper(II) complexes Schiff base-derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the mode ligands to be through N imine deprotonated phenol coumarin-derived ligand in solution. In addition, more active their corresponding presence liquid frozen solution ESR A series secondary amine derivatives base isolated with solubility characteristics...
Candida haemulonii, haemulonii var. vulnera and duobushaemulonii, which form the C. complex, are emerging etiologic agents of fungal infections known to be resistant most commonly used antifungals. The well-established anti-Candida potential metal complexes containing 1,10-phenanthroline (phen) ligands encouraged us evaluate different copper(II), manganese(II), silver(I) phen chelates for their ability inhibit planktonic growth biofilm species complex. Two novel coordination complexes,...
ObjectivesThe beneficial antimicrobial properties of 1,10-phenanthroline (phen)-based drugs, together with the imperative need to develop new chemotherapeutic options for prevention/treatment infections caused by MDR Gram-negative bacteria, led us evaluate effects phen, 1,10-phenanthroline-5,6-dione (phendione), [Ag(phendione)2]ClO4 and [Cu(phendione)3](ClO4)2·4H2O on planktonic- biofilm-growing Pseudomonas aeruginosa.