A5061911458- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Reactivity of Heterocycles
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Cancer Treatment and Pharmacology
- Diatoms and Algae Research
- Luminescence and Fluorescent Materials
- Chemical Synthesis and Reactions
- Signaling Pathways in Disease
- Organic Chemistry Cycloaddition Reactions
- Material Science and Thermodynamics
- Material Properties and Applications
- Advanced Nanomaterials in Catalysis
- Synthesis and Characterization of Pyrroles
- Covalent Organic Framework Applications
- Silicone and Siloxane Chemistry
HUN-REN Research Centre for Natural Sciences
2006-2024
Institute of Organic Chemistry
2014-2024
Hungarian Research Network
2022
Institute of Materials and Environmental Chemistry
2021
Hungarian Academy of Sciences
2012-2018
A recently proposed strategy to overcome multidrug resistance (MDR) in cancer is target the collateral sensitivity of otherwise resistant cells. We designed a library 120 compounds explore chemical space around previously identified 8-hydroxyquinoline-derived Mannich bases with robust MDR-selective toxicity. included study effect halogen and alkoxymethyl substitutions R5 combination different R7, shift base from R7 R5, as well introduction an aromatic moiety. Cytotoxicity tests performed on...
2-Arylsulfanyl- and benzylsulfanylpyridinium N-arylimides (2), easily available from tetrazolo[1,5-b]pyridinium salts (1), participate in 1,3-dipolar cycloaddition with aryl isothiocyanates isocyanates to result formation of fused thioxo- oxo[1,2,4]triazolium (5 12), respectively. This transformation is interpreted as a regular 1,3-cycloaddition followed by spontaneous elimination the aryl- or benzylsulfanyl group. Formation these triazolium can be followed--under appropriate reaction...
6-Methyl substituted 2-aryl- and 2-benzylthiopyridinium N-imides reacted with an excess of isocyanates to give N,N-disubstituted exocyclic1H-imidazo[4,5-b]pyridin-2(3H)-ones. The products easily underwent spontaneous [1,5] hydrogen shift provide the heteroaromatic imidazopyridinone isomers. transformation implied initial formation [1,2,4]triazolo[2,3-a]pyridinium salt, followed by deprotonation carbamoylation methylene moiety, and, finally, a rearrangement following [1,3] sigmatropic...
A general and versatile strategy has been developed for the functionalization of carbocyclic core isoquinoline. This regioexhaustive approach employs electrophilic halogenation as a toolbox methodology delivers highly decorated intermediates that can be further elaborated toward medicinally relevant building blocks or natural products.
The polymorphs of a cationic iHOF constructed by anion⋯pi interactions and the role molecular inflexibility in framework construction are presented.
Reaction of aryl- and benzylsulfanopyridinium amidates bearing a methyl group in position 6 with 2 equiv diphenylketene afforded spiro-fused ring system: azoniabenzo[de]fluorine. By use an excess amount ketene, distinct reaction was observed via which 1H-pyrrolo[3,2-b]pyridin-2(3H)-one derivative furnished. The structure the tetracyclic system unambiguously confirmed by X-ray diffraction, its formation rationalized DFT calculations.
Maternal Embryonic Leucine-zipper Kinase (MELK) is a current oncotarget involved in diverse range of human cancers, with the usage MELK inhibitors being explored clinically. Here, we aimed to discover new inhibitor chemotypes from our in-house compound library consensus-based virtual screening workflow, employing three concepts. After careful retrospective validation, prospective and vitro enzyme inhibition testing revealed series [1,2,4]triazolo[1,5-b]isoquinolines as structural class...
Some novel 1-cyanoisobenzofurans have been synthesized by a convenient ring closure methodology.The new products easily reacted with electron-deficient olefins and acetylenes to yield Diels-Alder products.Theoretical calculations satisfactorily support the quinonoide character of isobenzofuran derivatives.
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Abstract A series of novel isobenzofurans (III) is prepared and used as starting compounds in the synthesis Diels—Alder adducts (V), (VII), (IX), (X).
Abstract Treatment of pyridinium imides type (I) with an excess isocyanates allows a new access to biologically important imidazopyridinones.