A5058569801- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Click Chemistry and Applications
- Ferrocene Chemistry and Applications
- Antimicrobial agents and applications
- Synthesis of Tetrazole Derivatives
- Marine Sponges and Natural Products
- Bacterial biofilms and quorum sensing
- Cancer Mechanisms and Therapy
- Plant-Microbe Interactions and Immunity
- Algal biology and biofuel production
- Bacterial Genetics and Biotechnology
- Crystal structures of chemical compounds
- Microbial Metabolism and Applications
- Crystallography and molecular interactions
- Organometallic Compounds Synthesis and Characterization
- Genomics and Phylogenetic Studies
- Porphyrin and Phthalocyanine Chemistry
- Plant chemical constituents analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Activity
University of Belgrade
2015-2024
Institute of Molecular Genetics and Genetic Engineering
2005-2024
University of Fribourg
2020
Institute of Molecular Genetics
2010-2018
Inspired by the emergence of resistance to currently available antifungal therapy and great potential metal complexes for treatment various diseases, we synthesized three new silver(I) containing clinically used azoles as ligands, [Ag(ecz)
We have prepared a series of ten 3-arylcoumarin molecules, their respective fac-[Re(CO)3(bpy)L]+ and fac-[Re(CO)3(L⁀L)Br] complexes tested all compounds for antimicrobial efficacy. Whereas the ligands are virtually inactive against human-associated pathogens with minimum inhibitory concentrations (MICs) > 150 μM, when coordinated to fac-[Re(CO)3]+ core, most resulting showed remarkable antibacterial potency. Several rhenium exhibit activity in nanomolar Gram-positive such as Staphylococcus...
Molecular modifications on sulfathiazole to overcome sulfonamide resistance: the discovery of selective antibacterial agents against <italic>Staphylococcus aureus</italic>.
Recognizing that metal ions play an important role in modifying the pharmacological properties of known organic-based drugs, present manuscript addresses complexation antifungal agent voriconazole (vcz) with biologically relevant silver(I) ion as a strategy for development new antimycotics. The synthesized complexes vcz were characterized by mass spectrometry, IR, UV–Vis and NMR spectroscopy single-crystal X-ray diffraction analysis. crystallographic results showed {[Ag(vcz)(H2O)]CH3SO3}n...
Systemic toxicity and severe side effects are commonly associated with anticancer chemotherapies. New strategies based on enhanced drug selectivity targeted delivery to cancer cells while leaving healthy tissue undamaged can reduce the global patient burden. Herein, we report design, synthesis characterization of a bio-inspired hybrid multifunctional system diatom microalgae. The microalgae's surface was chemically functionalized vitamin B12-photoactivatable molecules materials further...
Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, characterization prodigiosin (PG) from easily accessible Serratia marcescens ATCC 27117 strain has been achieved to levels 14 mg/L culture within 24 h. Furthermore, environmentally friendly bromination produced PG was used afford both novel mono- dibrominated derivatives PG. its Br showed anticancer potential IC50...
Dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz) was used as a ligand for the synthesis of new copper(ii) and silver(i) complexes, [CuCl2(py-2pz)]2 (1), [Cu(CF3SO3)(H2O)(py-2pz)2]CF3SO3·2H2O (2), [Ag(py-2pz)2]PF6 (3) {[Ag(NO3)(py-2pz)]·0.5H2O} n (4). The complexes were characterized by spectroscopic electrochemical methods, while their structures determined single crystal X-ray diffraction analysis. analysis revealed bidentate coordination mode py-2pz to corresponding metal ion...
Silver(<sc>i</sc>) complexes with pyridine-4,5-dicarboxylates show significant activity against clinical isolates from the milk of a cow diagnosed mastitis.
Gold(<sc>iii</sc>) complexes with<sc>l</sc>-Ala-<sc>l</sc>-His and<sc>l</sc>-Leu-<sc>l</sc>-His dipeptides inhibit angiogenesis.
Diverse and elaborate pathways for nutrient utilization, as well mechanisms to combat unfavourable conditions make Pseudomonas putida KT2440 a versatile micro-organism able occupy range of ecological niches. The fatty acid degradation pathway P. is complex correlated with biopolymer medium chain length polyhydroxyalkanoate (mcl-PHA) biosynthesis. Little known about the second step (β-oxidation) in this strain. In silico analysis its genome sequence revealed 21 putative acyl-CoA...
Diarylheptanoids from the barks of <i>Alnus viridis</i> ssp. <i>viridis</i> (green alder) and glutinosa</i> (black were explored for anti-quorum sensing activity. Chemicals with activity have recently been examined antimicrobial applications. The selected diarylheptanoids was determined using two biosensors, namely <i>Pseudomonas aeruginosa</i> PAO1 <i>Chromobacterium violaceum</i> CV026. Although all investigated compounds negatively influenced motility <i>P. PAO1, four able to inhibit...
Silver(<sc>i</sc>) complexes with a pyridine-based macrocyclic ligand show significant activity against microbial pathogens both in planktonic and early biofilm forms.
Bioleaching of samples taken from depths 10, 15, and 20 meters old flotation tailings the Copper Mine Bor was conducted in shaken flasks using extremely acidic water Lake Robuleas lixiviant. Yield copper after five weeks bioleaching experiment 68.34?1.21% for 15 m sample, 72.57?0.57% sample 97.78?5.50% 10 sample. The obtained results were compared to acid leaching same it concluded that generally more efficient treatment m. content pyrite which contained highest amount this mineral, reduced...
1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO 3 } n ( 1 ), {[Ag(bpa) 2 ]CF SO . H O} ) {[Ag(bpe)]CF ). In complexes 1–3 , corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. vitro antimicrobial activity these along with ligands their synthesis, was evaluated against broad panel Gram-positive Gram-negative bacteria fungi. The showed selectivity towards...
Curcumin and triangular silver nanoplates (TSNP)-incorporated bacterial cellulose (BC) films present an ideal antimicrobial material for biomedical applications as they afford a complete set of requirements, including broad range long-lasting potency superior efficacy activity, combined with low toxicity. Here, BC was produced by Komagataeibacter medellinensis ID13488 strain in the presence curcumin production medium (2 10%). TSNP were incorporated BC/curcumin using ex situ method (21.34...