A5015185233- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- Cholinesterase and Neurodegenerative Diseases
- Chemistry and Chemical Engineering
- Glaucoma and retinal disorders
- Free Radicals and Antioxidants
- Metal complexes synthesis and properties
- Machine Learning in Materials Science
- Synthesis and Biological Evaluation
- Ferrocene Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Intraocular Surgery and Lenses
- Chemical Thermodynamics and Molecular Structure
- Phytochemicals and Antioxidant Activities
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacological Receptor Mechanisms and Effects
- Enzyme function and inhibition
- Analytical Methods in Pharmaceuticals
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
University of Nis
2016-2025
Faculty (United Kingdom)
2017-2021
Klinički centar Niš
2010-2020
Ophthalmology Clinic
2010-2017
ACTA (United States)
2015
University Clinical Centre
2011
University of British Columbia
2005
Background and Objectives: This study explores the relationship between retinal structure, vascular densities (VD), progression of myopia, aiming to identify novel biomarkers for assessing myopia severity. Materials Methods: A total 260 eyes were divided into four groups: Emmetropia (EM) (n = 74), Low Myopia (LM) 68), Moderate (MM) 64), High (HM) 54). VD thickness (RT) in macular peripheral quadrants measured using optical coherence tomography-angiography (OCTA). SVD DVD analyzed across...
The inhibitory effects of two novel lophine derivatives were unexpectedly discovered during the development a chemiluminescent monoacylglycerol lipase (MAGL) assay. proposed found to exhibit concentration-dependent on MAGL with octanoic and palmitic acid esters 2-(4-hydroxyphenyl)-4,5-diphenylimidazole showing strongest activity. Reversibility assays using fluorometric method confirmed that these compounds interact in stable, irreversible manner. To further investigate their mode...
A series of 16 Pt(<sc>ii</sc>) complexes with 8-hydroxyquinolines and sulfoxide/phosphine ligands were synthetized, characterized evaluated for cytotoxic embryotoxic activity.
Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series pyrazine (pz) bridged dinuclear general formulas {[Pt(L)Cl]2(μ-pz)}2+ (L, ethylenediamine, en; (±)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(±)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) {[Pt(en)Cl]2(μ-pydz)}2+ complex were prepared. The these determined...
Copper(II) and zinc(II) complexes with clinically used antifungal drug fluconazole (fcz), {[CuCl2(fcz)2].5H2O}n, 1, {[ZnCl2(fcz)2]·2C2H5OH}n, 2, were prepared characterized by spectroscopic crystallographic methods. The polymeric structure of the comprises four molecules monodentately coordinated via triazole nitrogen two chlorido ligands. With respect to fluconazole, complex 2 showed significantly higher activity against Candida krusei parapsilosis. All tested compounds reduced total amount...
A series of 278 organophosphate compounds acting as acetylcholinesterase inhibitors has been studied. The Monte Carlo method was used a tool for building up one-variable quantitative structure–activity relationship (QSAR) models inhibition activity based on the principle that target endpoint is treated random event. As an activity, bimolecular rate constants were used. QSAR optimal descriptors obtained from Simplified Molecular Input-Line Entry System (SMILES) representation molecular...
In a search for novel antimicrobial metal-based therapeutic agents, mononuclear gold(III) complexes 1-7 of the general formula [AuCl3(azole)], where azole stands imidazole (im, 1), 1-isopropylimidazole (ipim, 2), 1-phenylimidazole (phim, 3), clotrimazole (ctz, 4), econazole (ecz, 5), tioconazole (tcz, 6) and voriconazole (vcz, 7) were synthesized, characterized biologically evaluated. all complexes, corresponding ligand is monodentately coordinated to Au(III) via or triazole nitrogen atom,...
Abstract The activity of 72 1,4‐dihydropyridines as calcium channel antagonists was examined. simplified molecular input‐line entry system (SMILES) used representation the structure antagonists. Quantitative structure–activity relationships (QSARs) were developed using CORAL software ( http://www.insilico.eu/CORAL ) for four random splits data into training and test sets. Using Monte Carlo method, generated optimal descriptors one‐variable models. reproducibility each model tested performing...