A5058335921- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Nanocluster Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Ferrocene Chemistry and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- biodegradable polymer synthesis and properties
- Synthesis and Biological Evaluation
- Antimicrobial agents and applications
- Magnetism in coordination complexes
- Synthesis of Tetrazole Derivatives
- Corrosion Behavior and Inhibition
- Organometallic Complex Synthesis and Catalysis
- Protein Hydrolysis and Bioactive Peptides
- Petroleum Processing and Analysis
- Supramolecular Self-Assembly in Materials
- Lanthanide and Transition Metal Complexes
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Electrochemical sensors and biosensors
- Hemoglobin structure and function
- Alzheimer's disease research and treatments
- Click Chemistry and Applications
KU Leuven
2020-2025
University of Kragujevac
2015-2025
Abstract Oxidative modifications of proteins are key to many applications in biotechnology. Metal-catalyzed oxidation reactions efficiently oxidize but with low selectivity, and highly dependent on the protein surface residues direct reaction. Herein, we demonstrate that discrete inorganic ligands such as polyoxometalates enable an efficient selective oxidative cleavage. In presence ascorbate (1 mM), Cu-substituted polyoxometalate K 8 [Cu 2+ (H 2 O)(α -P W 17 O 61 )], (Cu II WD, 0.05 mM)...
The development of catalysts for controlled fragmentation proteins is a critical undertaking in modern proteomics and biotechnology. {Zr6O8}-based metal–organic frameworks (MOFs) have emerged as promising candidates catalysis peptide bond hydrolysis due to their high reactivity, stability, recyclability. However, emerging evidence suggests that protein mainly occurs on the MOF surface, thereby questioning need highly porous 3D nature. In this work, we show discrete water-soluble...
A chloride salt of the tetrameric gold(III) complex with L-valyl-L-histidine dipeptide (L-Val-L-His), [Au(L-Val-L-His)]4Cl2·14.5H2O, was obtained from mononuclear [Au(L-Val-L-His)Cl]Cl·2H2O species at pH 7.00 in aqueous solution room temperature. The characterized by 1H NMR and IR spectroscopic techniques, while its structure determined single-crystal X-ray diffraction analysis. In title compound, each ion is coordinated three nitrogen atoms, as corresponding (amine NA, deprotonated amide...
Combination therapy may be applied in the case of gold(<sc>iii</sc>) and silver(<sc>i</sc>) complexes with aromatic nitrogen-containing heterocycles to improve their antimicrobial activity reduce toxic-side effects.
Despite the enormous importance of insoluble proteins in biological processes, their structural investigation remains a challenging task. The development artificial enzyme-like catalysts would greatly facilitate elucidation structure since currently used enzymes proteomics largely lose activity presence surfactants, which are necessary to solubilize proteins. In this study, hydrolysis fully protein by polyoxometalate complexes as proteases surfactant solutions is reported for first time....
New silver(<sc>i</sc>) complexes with quinazoline and phthalazine have been synthesized, characterized evaluated for their antimicrobial activity effect on the viability of fibroblasts development zebrafish embryos.
Gold(<sc>iii</sc>) complexes with<sc>l</sc>-Ala-<sc>l</sc>-His and<sc>l</sc>-Leu-<sc>l</sc>-His dipeptides inhibit angiogenesis.
Abstract The development of artificial proteases is challenging, but important for many applications in modern proteomics and biotechnology. hydrolysis hydrophobic or unstructured proteins particularly difficult due to their poor solubility, which often requires the presence surfactants. Herein, it shown that a zirconium(IV)‐substituted Keggin polyoxometalate (POM), (Et 2 NH ) 10 [Zr(α‐PW 11 O 39 ] ( 1 ), able selectively hydrolyze β‐casein, an intrinsically protein at pH 7.4 60 °C. Four...
Silver(<sc>i</sc>) complexes with a pyridine-based macrocyclic ligand show significant activity against microbial pathogens both in planktonic and early biofilm forms.
The hydrolysis of the iron-binding blood plasma glycoprotein transferrin (Tf) has been examined at pH = 7.4 in presence a series Zr-substituted polyoxometalates (Zr-POMs) including Keggin (Et
Abstract Controlled protein hydrolysis is an important procedure in proteomics applications and used to aid the understanding of structure function. The hydrophobic proteins particularly challenging, as due their poor solubility use surfactants, which typically inactivate natural enzymes, often required. Such limitations enzymes prompted development chemical catalysts for selective proteins. In this study, nanozymatic potential MOF‐808, a Zr 6 O 8 based metal organic framework, has been...
The development of robust artificial proteases is crucial importance for the study proteins since natural only retain their proteolytic activity under specific conditions. presence surfactants, which aid in solubilizing and probing structure, particularly detrimental to proteases. Therefore, that can function surfactants are needed. Here, we report hydrolysis horse heart myoglobin (Mb) a Zr(IV)-substituted Keggin polyoxometalate cluster (Et2NH2)8[{α-PW11O39Zr-(μ-OH)(H2O)}2]·7H2O (Zr–K 2:2)...
Aromatic character of nitrogen-containing rings is decreased upon gold(<sc>iii</sc>) coordination.
1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO 3 } n ( 1 ), {[Ag(bpa) 2 ]CF SO . H O} ) {[Ag(bpe)]CF ). In complexes 1–3 , corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. vitro antimicrobial activity these along with ligands their synthesis, was evaluated against broad panel Gram-positive Gram-negative bacteria fungi. The showed selectivity towards...
Dinuclear Au(<sc>iii</sc>) complexes with N-heterocycles have been synthesized and biologically evaluated.
Development of catalysts for the selective hydrolysis proteins is challenging, yet important many applications in biotechnology and proteomics. The hydrophobic particularly as due to their poor solubility, use surfactants often required. In this study, proteolytic potential catalyst systems based on Zr(IV)-substituted Keggin polyoxometalate (Et2NH2)10[Zr(PW11O39)2] (Zr-K 1:2) three different (ionic SDS (sodium dodecyl sulfate); zwitterionic Zw3-12...
Abstract In this study, we demonstrate for the first time, that a discrete metal-oxo cluster α-/β-K 6 P 2 W 18 O 62 (WD-POM) exhibits superior performance as computed tomography (CT) contrast agent, in comparison to standard agent iohexol. A toxicity evaluation of WD-POM was performed according toxicological protocols using Wistar albino rats. The maximum tolerable dose (MTD) 2000 mg/kg initially determined after oral application. acute intravenous single doses (1/3, 1/5, and 1/10 MTD),...
Polyoxotungstate nanoclusters have recently emerged as promising contrast agents for computed tomography (CT). In order to evaluate their clinical potential, in this study, we evaluated the vitro CT imaging properties, potential toxic effects vivo, and tissue distribution of monolacunary Wells–Dawson polyoxometalate, α2-K10P2W17O61.20H2O (mono-WD POM). Mono-WD POM showed superior X-ray attenuation compared other tungsten-containing (its parent WD-POM Keggin POM) standard iodine-based agent...