A comparative in vitro study of the antioxidant potential natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The efficiency evaluated blood serum obtained from healthy individuals, by means spectrophotometry, before after addition pro-oxidant tert-butyl hydroperoxide (TBH). Moreover, effect an equimolar mixture curcumin zingerone investigated. Interpretation our results reveals that individuals (C1), ketone (RK1), magnolol (M1)...

Cycloaddition reactions of azomethine ylides are the most direct way to synthesise pyrrolidine derivatives. They have been studied for several decades and become an indispensable tool in synthesis pyrrolidines derived natural products. Amongst many methods generating ylides, various processes involving imines from amino acid esters frequently studied. The use Lewis acids promote imine-ylide-cycloaddition sequence under mild conditions, recent years, has led development highly stereoselective...

The examination of the aerial parts, roots, and seeds endemic plant Rindera umbellata is reported in this paper for first time. Phytochemical investigation R. led to isolation characterization ten pyrrolizidine alkaloids eleven fatty acids form triglycerides. Pyrrolizidine 1-9 were found 7 8 6-10, together with acids, species. structures compounds 1-10 established based on spectroscopic studies (¹H- ¹³C-NMR, 2D NMR, IR CI-MS). After trans-esterification, methyl esters analyzed using GC-MS....

Abstract Enallenylamides have been utilized for the synthesis of heterobicycle[4.2.0]octane derivatives via Ir/hν promoted [2+2] cycloaddition reaction. The reaction specifically targets distal double bond allene moiety, and results in exclusive formation trans product. process is conducted at room temperature under an inert atmosphere. An extensive study on substituent propensities during step revealed variable effects. Electron‐withdrawing groups conjugated with participating either...

The genus Senecio (family Asteraceae) is one of the largest in world. It comprises about 1100 species which are rich source pyrrolizidine alkaloids. Plants containing alkaloids among most important sources human and animal exposure to plant toxins carcinogens. seven (S. erucifolius, S. othonnae, wagneri, subalpinus, carpathicus, paludosus rupestris) were studied. Fourteen isolated their structures determined from spectroscopic data (1H- 13C-NMR, IR MS). Five them identified four two three...

AbstractProcedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration volume acid, pH PA solution alkaline extraction, time techniques (maceration, ultrasonic overhead rotary mixer assisted extraction) were investigated. The yields six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, rinderine, punctanecine heliosupine) monitored by...

The redox balance plays a crucial role in maintaining biological processes under normal conditions. Antioxidants inhibit and reduce harmful oxidation processes, while pro-oxidants can act as anti-cancer agents by promoting ROS-mediated cell death. aim of this study is to compare the properties seven newly synthesised tribromopyrrole derivatives with three novel four previously synthesized non-halogenated analogues an vitro model (in human serum) exogenously induced oxidative stress. obtained...

π-Allylpalladium intermediates are known to participate efficiently in transformations involving nucleophilic species. Exploring these processes, we have developed a method for the preparation of allyl acetates via palladium-catalysed functionalisation allenes and 1,3-dienes. Reactions aryl iodides with either two classes compounds excess sodium acetate presence Pd(OAc)2 Ph3P as catalytic system afforded respective moderate good yields. The scope this process has been investigated. described...

A facile synthetic route has been developed for the preparation of pyrrolizinone derivatives employing N-allyl imides as starting materials. The nucleophilic addition a vinyl Grignard reagent/RCM/elimination sequence afforded pyrrolizinones in good yields and applied naturally occurring quinolactacide marinamide.

A novel thiourea organocatalyst was rationally designed by altering a typical H-bonding pattern of derivatives and utilising the potential 3,5-bis(trifluoromethyl)phenyl motif to participate in H-bond formation. This unique catalyst afforded products α-amination Michael reaction excellent yields with high level stereoselectivity. Although additional studies are necessary establish full broaden its application further, presented results may indicate alternative routes for further exploration...

Redox imbalance occurs when the factors of oxidative stress, known as prooxidants, outweigh mechanisms antioxidant protection. In a healthy state, homeostatic ensure balanced production free radicals and complete series antioxidants responsible for their safe removal. The generation is part physiological processes in organism, some which act specific signaling molecules, presence activity are necessary these processes. various diseases such cancer, cardiovascular disease, diabetes,...

ADVERTISEMENT RETURN TO ISSUEPREVArticlepKa of the +H3NCHCOOH radicalP. Neta, M. Simic, and E. HayonCite this: J. Phys. Chem. 1972, 76, 23, 3507–3508Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/j100667a038https://doi.org/10.1021/j100667a038research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are...

A novel synthetic route for highly substituted conjugated ketones has been developed utilizing glycals as starting materials. The two‐step process combined the Heck reaction/Lewis acid promoted ring opening to afford products in 33–80 % overall yields and with a high level of trans stereoselectivity. Since are essentially aldols, this methodology may be employed some cases an alternative typical aldol condensation. Densely substituted, selectively protected synthetically attractive...

Annulations of allene‐substituted proline derivatives promoted by transition metals have been investigated as a general way to access bicyclic structures with bridgehead nitrogen. Two processes, Pd‐ and Ag‐catalysed cyclisations, employed complementary control the substitution pattern product. The methodologies afforded in comparable yields, while Ag‐catalysis showed higher level diastereoselectivity. Both processes utilized synthesis naturally occurring pyrroles longamide B, stylisine D...

A novel and efficient synthetic route has been developed for the preparation of protoberberine derivatives. The methodology designed to control, primarily, substitution patterns on terminal rings, was used access a small array these compounds. Initial biological profiling suggested anticancer potential synthesised derivatives while structure-based target fishing identified their targets established rational basis further structural modifications. Although activities need improvement, our...

The aporphine alkaloid magnoflorine, known as a constituent of Asian Epimedium species, was isolated for the first time from wild growing European alpinum L. Identification done by comparison with literature data. HPLC method applied determination content in methanolic extracts plant material. underground part E. contains 1-2 % while its 9.2-11.8 %. aerial less (0.06-0.12 %), magnoflorine 0.4-0.8 Probably, high parts influences dose-dependent cytotoxic activity (300 ?g/ml; 39 survival cells...

In the continuation of our study substituted isocoumarins a series novel 3-azolyl isocoumarin and their thio derivatives, including some related lactone compounds was prepared biologically profiled against C. albicans showing moderate activity with MIC values in range 4?60 ?g mL-1, general. The additional characterisation selected carried out by exploring on CYP3A4 CYP2D6 enzymes, while experiments mutagenicity were performed AMES test. representative 3b, 4a 4b showed lower inhibitory CYP...

Abstract Octahydro‐dipyrroloquinoline skeleton is the building component of a very few naturally occurring compounds. Nevertheless, these natural products have been attractive synthetic targets, and their study commanded development efficient synthesis this core. While reported methods are based on dimerization procedure N‐arylpyrrolidines N‐arylhomopropargyl amines, our approach relay dipolar cycloaddition/amination sequence. This strategic allows sequential introduction aromatic moieties...

Abstract Several coumarin derivatives with a directly attached azole substituent at C‐4 were synthesized and biologically studied for their anticancer properties. The cell lines used this investigation (HeLa, K‐562, MDA‐MB‐53, MCF‐7) demonstrated different sensitivities. best response in the MTT (3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2 H ‐tetrazolium bromide) assay was shown by K‐562 cells, compounds displaying activity ( 3c , IC 50 3.06 μM; 4a 5.24 4c 4.7 μM) similar to that of...