Abstract Malignant transformation in invasive breast cancer (IBC) is the result of accumulation successive mutations critical regions genome. Another important mechanism for controlling malignant progression cellular senescence. Although some research suggests its protective role, recent studies have shown that senescence has a significant impact on development and cancer. The aim our work to examine potential prognostic value specific marker, β galactosidase (GLB1). investigation...

Six β-hydroxy-β-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These belong to the aryl acid class compounds, structurally similar NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expected. The aim this work was determine activity, examine gastric tolerability, carry out molecular docking experiments identify potential COX-2 inhibitors among acids, elucidate effect α-methyl substitution on activity....

Nonsteriodal anti-inflammatory drugs (NSAIDs) are numerous and widely used for more than 60 years, but there is still a strong need developing novel selective NSAIDs. The justified by the fact that nonselective NSAIDs can produce serious gastric side effects some of NSAID withdrawn due to their cardiotoxic effects.Eight β-hydroxy-β-arylpropanoic acids, which belong arylpropanoic acid class compounds, structurally similar nonsteroidal (NSAIDs), were docked into 3D catalytic site both...

Redox imbalance occurs when the factors of oxidative stress, known as prooxidants, outweigh mechanisms antioxidant protection. In a healthy state, homeostatic ensure balanced production free radicals and complete series antioxidants responsible for their safe removal. The generation is part physiological processes in organism, some which act specific signaling molecules, presence activity are necessary these processes. various diseases such cancer, cardiovascular disease, diabetes,...

Abstract Oral anticoagulants are a group of drugs used for the prevention and treatment venous thrombosis thromboembolism. For last ten years, direct oral (DOAC) have been available equally effective, but significantly safer than vitamin K antagonists. In case an overdose, their most important side effect is still bleeding. Due to widespread use, as well increased toxicological importance there need develop analytical method determination DOAC in biological material. The aim this paper was...

The pKa values of twelve ?-hydroxy-?-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. stationary phase was octadecyl (C-18) silica gel, the mobile phases mixtures methanol one ten different buffers (60:40 volume ratio). mean retention time each compound plotted against pH used phases. inflection point obtained sigmoidal curve represents s w compound. Using in previously established equations for specific methanol/buffer mixture, (in pure water) calculated....

pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, mobile a mixture methanol one nine different buffers (60:40, v/v). wspH measured after mixing with an appropriate buffer. The mean retention time each compound plotted against phase. inflection point sigmoidal curve represented wspK compound. Using in already known equations for specific methanol/buffer mixture, wwpK calculated....

Evaluation of pharmacokinetic properties is a significant step at the early stages drug development. In this study, an in vitro evaluation five newly synthesized compounds was performed. These belong to N-hydroxyurea and hydroxamic acid derivatives analogs NSAIDs indomethacin, flurbiprofen, diclofenac, ibuprofen, naproxen (compounds

Abstract The serotonin receptor ligands and their related compounds are used for the treatment of central nervous system (CNS)-related disorders. retention profile six such as aripiprazole, ziprasidone, risperidone, olanzapine, mianserin, quetiapine was investigated on two stationary phases that differ in polarities (C8 alkyl pentafluorophenylpropyl (PFP)). design experiments (DoE) methodology to define mechanism produce acceptable separation results. chromatographic conditions provide best...

Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but also cancer, atherosclerosis, Alzheimer's disease, Parkinson's disease. Potential cardiovascular hepatic side effects of cyclooxygenase-2 have limited their use. The development safe remains a high priority drug discovery. Based on the structure...

Lipophilicity parameters (logP) were determined for thirteen synthesized β-hydroxy-β-arilalkanoic acids using reversed phase high performance liquid chromatography. Anti-inflammatory activity and potential selectivity towards cyclooxygenase-2 inhibition of synthetized compounds was assessed. Stationary octadecyl modified (C-18) silicagel, four used mobile phases contained different amount methanol. Both standard with known logP values (aspirin, ibuprofen, ketoprofen, naproxen phenanthrene)...

Abstract Neonatal pneumopericardium, a collection of air in the pericardial sac, is less common form leak syndrome, but unfortunately with high mortality rate. We report rare case male fullterm newborn who soon after birth presented respiratory distress. Chest radiograph showed spontaneous bilateral pneumothorax which chest drain was placed between anterior and midaxillary line 5 th right intercostal space. The infant tachypnea, dyspnea, muffled heart sounds, acidosis indicating...

Abstract Bacterial DNA gyrase and topoisomerase IV control the topological state of during replication represent important antibacterial drug targets. To be successful as candidates, newly synthesized compounds must possess optimal lipophilicity, which enables efficient delivery to site action. In this study, retention behavior twenty-three previously dual inhibitors was tested in RP-HPLC system, consisting C8 column acetonitrile/phosphate buffer (pH 5.5 pH 7.4) mobile phase. logD calculated...