A5015771964- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Inflammatory mediators and NSAID effects
- Advancements in Transdermal Drug Delivery
- Computational Drug Discovery Methods
- Advanced Drug Delivery Systems
- Cancer therapeutics and mechanisms
- Estrogen and related hormone effects
- Bioactive Compounds and Antitumor Agents
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Synthesis and Biological Evaluation
- Dermatology and Skin Diseases
- Clay minerals and soil interactions
- Eicosanoids and Hypertension Pharmacology
- Advanced biosensing and bioanalysis techniques
- Drug Transport and Resistance Mechanisms
- Surfactants and Colloidal Systems
- Analytical Chemistry and Sensors
- Antibiotics Pharmacokinetics and Efficacy
- Microencapsulation and Drying Processes
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
University of Belgrade
2016-2025
Deleted Institution
2019-2024
The aim of the study was a synthesis and investigation dose-dependent anti-inflammatory effect new thiourea derivatives naproxen with selected aromatic amines esters amino acids. results in vivo indicate that m-anisidine (4) N-methyl tryptophan methyl ester (7) showed most potent activity four hours after injection carrageenan, percentage inhibition 54.01% 54.12%, respectively. In vitro assays COX-2 demonstrated none tested compounds achieved 50% at concentrations lower than 100 µM. On other...
The objective of this study was to synthesize seven novel thiourea derivatives naproxen (8–14), examine the anti-inflammatory activity newly synthesized compounds, investigate cytotoxic potential both sets compounds (1–7 and 8–14), select most promising antitumor drug candidates. results in vivo clearly showed that 8 9 were capable decreasing paw edema, as evident from a high percentage inhibition (44.83% 49.29%, respectively). In addition, vitro enzyme assays demonstrated neither reached...
Background/Objectives: The novel pyrazoloquinolinone ligand CW-02-79 shows a unique profile of selective binding to σ2 receptors, but its poor solubility in both water and lipids makes research development burdensome task. We aimed develop phospholipid-complex-based nanoemulsion formulation containing suitable for intravenous administration preclinical research. Methods: decorated undecorated nanoemulsions were formulated subjected detailed physiochemical characterization. delivery exposure...
Background/Objectives: Acridine, an aromatic heterocyclic compound, serves as a basis for the synthesis of potent bioactive derivatives, displaying broad spectrum biological activity, such antibacterial, antitumor, and antiparasitic activity. With ability to undergo various types electrophilic substitutions, introducing different side chains could lead compounds being active towards potentially multiple biotargets. Toxoplasma gondii, ubiquitous protozoan parasite with worldwide distribution,...
Recent reports indicate that α6β2/3γ2 GABAAR selective ligands may be important for the treatment of trigeminal activation-related pain and neuropsychiatric disorders with sensori-motor gating deficits. Based on 3 functionally pyrazoloquinolinones, 42 novel analogs were synthesized, their in vitro metabolic stability cytotoxicity as well vivo pharmacokinetics, basic behavioral pharmacology, effects locomotion investigated. Incorporation deuterium into methoxy substituents increased duration...
The majority of drugs have a low dissolution rate, which is limiting step for their absorption. In this manuscript, solid dispersions (SD), self-microemulsifying drug delivery systems (S-SMEDDS) and self-nanoemulsifying (S-SNEDDS) were evaluated as potential formulation strategies to increase the rate carbamazepine. Influence increased on permeability carbamazepine was using PAMPA test. S-SMEDDS S-SNEDDS formulations, ratio liquid SMEDDS/SNEDDS carrier (Neusilin® UFL2) varied, content...
Apart from cytotoxicity, inhibitors of the COX-2 enzyme have demonstrated additional effects important for cancer treatment (such as radiosensitization tumor cells and cell antimigratory effects); however, relationship between inhibition other inflammation-related 5-LOX anticancer activity is still not well understood. In our study, cytotoxicity thirteen previously presented by group (1–13) was tested on three lines (HCT 116, HT-29 BxPC-3) one healthy line (MRC-5). Compounds 3, 5, 6 7 showed...
Background – Myotonic dystrophy type 1 (DM1) is the most common muscular in adults. There a complete lack of studies that assessed quality life (QoL) trajectory during time DM1 cohorts. Aim To analyze changes QoL patients with 5-year follow-up period and to assess responsiveness SF-36 questionnaire. Patients Method At baseline, this study comprised 84 patients, whom 62 were retested after mean 64.2 ± 3.9 months. Severity weakness was using Muscular Impairment Rating Scale (MIRS). completed...