A5063394076- Folate and B Vitamins Research
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Exercise and Physiological Responses
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Garlic and Onion Studies
- Diabetes Treatment and Management
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Cardiac Arrest and Resuscitation
- Chemotherapy-induced organ toxicity mitigation
- Phytochemicals and Antioxidant Activities
- Chemotherapy-induced cardiotoxicity and mitigation
- Neuropeptides and Animal Physiology
- Heart Rate Variability and Autonomic Control
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Metal complexes synthesis and properties
- Cardiomyopathy and Myosin Studies
- Peptidase Inhibition and Analysis
University of Kragujevac
2016-2025
Sechenov University
2022-2025
Redox (Norway)
2023
University of Louisville
2016-2021
Czech Academy of Sciences, Institute of Physiology
2018
The aim of our study was to examine the effects different dietary strategies, high-fat (HFd) or standard diet (Sd) alone in combination with standardized oral supplementation (0.45 mL/kg/day) Aronia melanocarpa extract (SAE) rats metabolic syndrome (MetS). SAE is an official product pharmaceutical company Pharmanova (Belgrade, Serbia); however, procedure for extraction done by EU-Chem Serbia). Rats were divided randomly into six groups: control Sd, Sd and SAE, MetS HFd, HFd during 4 weeks....
This study aimed to examine the effects of diallyl trisulfide (DATS), most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with (MetS). For that purpose, we used 36 male Wistar albino divided into control rats, MetS treated 40 mg/kg DATS every second day for 3 weeks. In first part, studied impact found significantly raised H2S, decreased homocysteine glucose levels enhanced lipid antioxidative, while reducing prooxidative parameters....
The phytochemical analysis of the investigated Immortelle essential oil revealed presence monoterpenes and sesquiterpenes as major components that might be efficient a wound healing potential agent. present study aimed to develop an ointment based on investigate its effects excision wounds in diabetic rats. topical formulated was subjected pharmaco-technical characterization. Thirty-two rats with induced were used evaluate vivo ointment. animals randomly divided into four groups untreated or...
The aim of the study was a synthesis and investigation dose-dependent anti-inflammatory effect new thiourea derivatives naproxen with selected aromatic amines esters amino acids. results in vivo indicate that m-anisidine (4) N-methyl tryptophan methyl ester (7) showed most potent activity four hours after injection carrageenan, percentage inhibition 54.01% 54.12%, respectively. In vitro assays COX-2 demonstrated none tested compounds achieved 50% at concentrations lower than 100 µM. On other...
Background: The impact of the SARS-CoV-2 viral infection during pregnancy on fetus can be direct—transmitted through placenta—and indirect—creating unfavorable conditions for development because inflammation, micro-thrombosis, and hypercoagulation. Our study aimed to determine types frequency pathohistological changes in placental tissue SARS-CoV-2-positive pregnant women examine possible role oxidative stress prognosis delivery its maternal fetal complications. Methods: This prospective...
The aim of this study was to identify some the secondary metabolites present in acetonic, methanolic, and hexanic extracts lichen Xanthoparmelia stenophylla examine their antioxidant, antimicrobial, cytotoxic activity. Compounds depsid structure lecanoric acid, obtusic atranorin as well usnic acid with a dibenzofuran were identified by HPLC. acetone extract shown have highest total phenolic (167.03 ± 1.12 mg GAE/g) flavonoid content (178.84 0.93 QE/g) best antioxidant activity (DPPH IC50 =...
Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that ubiquitously expressed in all cell types of vasculature. TLR-4 activation known inflammation associated with pathogenesis hypertension. In this study we hypothesize HHcy induces hypertension by activation, which promotes inflammatory cytokine (IL-1β, IL-6, and TNF-α) upregulation initiation mitochondria-dependent apoptosis,...
The aim of the present study was to investigate whether short-term, concurrent exercise training before hindlimb suspension (HLS) prevents or diminishes both soleus and gastrocnemius atrophy analyze changes in mitochondrial molecular markers were associated. Male C57BL/6 mice assigned control at 13 ± 1 wk age, 7-day HLS 12 age (HLS), 2 10 (Ex+HLS), 11 (Ex) groups. resulted a 27.1% 21.5% decrease muscle weight-to-body weight ratio, respectively. Exercise 5.6% 8.1% increased biogenesis-...
Galium verum L . ( G , lady’s bedstraw ) is a perennial herbaceous plant, belonging to the Rubiaceae family. It has been widely used throughout history due multiple therapeutic properties. However, effects of this plant species on functional recovery heart after ischemia have still not fully clarified. Therefore, aim our study was examine methanol extract G. myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), with special emphasis role oxidative stress....
The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model metabolic syndrome (MetS). This included 40 Wistar rats divided into 5 groups: CTRL-healthy non-treated rats; MetS-non-treated H-TV, M-TV L-TV-rats with MetS treated either 300, 200 or 100 mg/kg TVH per os for 4 weeks. After finishing treatment, we conducted an oral glucose tolerance test (OGTT), hemodynamic measurements animals were...
Objective:The aim of this study was to compare protective effects ischemic and potential pharmacological preconditioning with omeprazole on isolated rat heart subjected ischemia/reperfusion.Methods: The hearts male Wistar albino rats were excised perfused a Langendorff apparatus.In control group (CG) after stabilization period, global ischemia (perfusion totally stopped) for 20 minutes 30 reperfusion.Hearts II (IPC) submitted lasting 5 before reperfusion.In third (OPC) first underwent 100µM...
Abstract The aim of our study was to assess and compare the effects dipeptidyl peptidase 4 (DPP4) inhibitors, saxagliptin sitagliptin, on metabolic control disease cardiac function in rats with diabetes mellitus type 2 (T2DM). This research would provide novel understanding into potentially protective DPP4 inhibitors helping salvage heart exposed ischaemia–reperfusion (I–R) injury. Forty‐eight Wistar albino were randomly divided four groups: CTRL, Control healthy group; T2DM, T2DM; T2DM +...