A5025313751- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ferrocene Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Essential Oils and Antimicrobial Activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Pyrroles
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Hepatitis C virus research
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Bioactive Natural Diterpenoids Research
- Organometallic Compounds Synthesis and Characterization
- interferon and immune responses
- Antibiotic Resistance in Bacteria
- Sulfur-Based Synthesis Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Long-Term Effects of COVID-19
- Allergic Rhinitis and Sensitization
- Protein Hydrolysis and Bioactive Peptides
- Lichen and fungal ecology
- Metabolism and Genetic Disorders
University of Kragujevac
2015-2025
Abstract Antibiotic resistance is one of the most significant problems in everyday clinical practice. The number bacterial strains, as well antibiotics to which they are resistant, has been constantly increasing over past few decades. One main causes this excessive and improper use antibiotics. essential significance phenomenon reflected increasingly difficult treatment bacterial, primarily nosocomial, infections. There numerous mechanisms by bacteria achieve antibiotic resistance, but...
Macrolides, lincosamides, and streptogramins (MLS) resistance genes are responsible for to these antibiotics in Staphylococcus infections. The purpose of the study was analyze distribution MLS community- hospital-acquired isolates. phenotypes [constitutive macrolide-lincosamide-streptogramin B (cMLSb), inducible (iMLSb), macrolide/macrolide-streptogramin (M/MSb), lincosamide-streptogramin A/streptogramin (LSa/b)] were determined by double-disc diffusion method. presence (ermA, ermB, ermC,...
Clinical manifestations of SARS-CoV-2 infection range from mild to critically severe. The aim the study was highlight immunological events associated with severity infection, an emphasis on cells innate immunity. Thirty COVID-19 patients mild/moderate symptoms and 27 severe/critically severe were recruited Center Kragujevac during April 2020. Flow cytometric analysis performed reveal phenotypic functional alterations peripheral blood correlate them disease. In cases, number T B lymphocytes,...
The aim of this study was to identify some the secondary metabolites present in acetonic, methanolic, and hexanic extracts lichen Xanthoparmelia stenophylla examine their antioxidant, antimicrobial, cytotoxic activity. Compounds depsid structure lecanoric acid, obtusic atranorin as well usnic acid with a dibenzofuran were identified by HPLC. acetone extract shown have highest total phenolic (167.03 ± 1.12 mg GAE/g) flavonoid content (178.84 0.93 QE/g) best antioxidant activity (DPPH IC50 =...
This paper presents the synthesis and structural characterization of a series new ruthenium(II) complexes 1-7, with general formula mer-[RuL3(N-N)Cl]Cl, where L is 2,2':6',2''-terpyridine (tpy) or 4'-(4-chlorophenyl)-2,2':6',2''-terpyridine (Cl-Ph-tpy) N-N o-benzoquinonediimine (o-bqdi), 2,3-naphthoquinonediimine (nqdi), 4,4'-dimethyl-2,2'-bipyridine (dmbpy) 2,2'-bipyridine-4,4'-dicarboxylic acid (dcbpy). The kinetic results showed that ligand substitution reactions Ru(II)-polypyridyl...
Acetylshikonin (AcSh), as a red colored pigment found in roots of the plants from family Boraginaceae, showed excellent cytotoxic activity. Due to its hydrophobic nature, and thus poor bioavailability, aim this study was prepare acetylshikonin/β-cyclodextrin (AcSh/β-CD) inclusion complex by using coprecipitation method, characterize obtained system UV/VIS, IR 1H NMR spectroscopy, determine Phase solubility test indicated formation AL-type binary (substrate/ligand ratio 1:1 M/M), with...
Dinuclear complexes [Pd<sub>2</sub>(tpbd)Cl<sub>2</sub>]Cl<sub>2</sub>, [Pt<sub>2</sub>(tpbd)Cl<sub>2</sub>]Cl<sub>2</sub> and [PdPt(tpbd)Cl<sub>2</sub>]Cl<sub>2</sub> (tpbd = <italic>N</italic>,<italic>N</italic>,<italic>N</italic>′,<italic>N</italic>′-tetrakis(2-pyridylmethyl)benzene-1,4-diamine) have been synthesized the kinetic, interactions with DNA/BSA cytotoxic activity were studied.
Hyssopus officinalis L. is a well-known aromatic plant used in traditional medicine and the food cosmetics industry. The aim of this study to assess antioxidant, genotoxic, antigenotoxic cytotoxic properties characterized hyssop essential oils methanol extracts. Chemical composition was analyzed by gas chromatography - mass spectrometry (GC-MS) liquid with diode array detection (LC-DAD-MS), respectively. Antioxidant activity examined 2,2-diphenyl-1-picrylhydrazyl (DPPH) ferric...
Coronavirus Disease 2019 (COVID-19) has been ranked among the most fatal infectious diseases worldwide, with host's immune response significantly affecting prognosis. With an aim to timely predict likely outcome of SARS-CoV-2 infection, we investigated association IFNL3 and IFNL4 polymorphisms, as well other potentially relevant factors, COVID-19 mortality. This prospective observational case-control study involved 178 patients, hospitalized at Corona Center or Clinic for Infectious Diseases...
Despite the pivotal role of IFN-λs in innate immune response, data on its genetic polymorphism relation to COVID-19 severity are scarce and contradictory. In present study, we aimed determine if presence most frequent functional single nucleotide polymorphisms (SNPs) two important coding genes, namely IFNL3 IFNL4, alters likelihood SARS-CoV-2-infected patients develop more severe form disease. This observational cohort study involved 178 hospitalized at University Clinical Centre Kragujevac,...
Four neutral Rh1-Rh4 complexes of the general formula [Rh
As cancer remains a significant global health challenge, there is an increasing need for novel therapeutic approaches. We investigated the antitumor potential of
In order to make progress in discovering the new agents for cancer treatment with improved properties and considering fact that 3-hydroxy-3-pyrrolin-2-ones belong a class of biologically active compounds, we tested series eleven novels 1,5-diaryl-4-(2- thienylcarbonyl)-3-hydroxy-3-pyrrolin-2-ones their antitumor potential.All novel compounds were characterized by spectral (IR, NMR, MS) elemental analysis. All screened cytotoxic activity on two cell lines, SW480 MDA-MB 231, non-transformed...
Purpose We aimed to determine the association of two most important functional polymorphisms IL-8 and IL-10 with clinical course outcome acute pancreatitis. Method Ninety-three patients pancreatitis were genotyped for -251T>A -1082G>A using PCR-RFLP. The severity disease was determined based on Atlanta Classification system. Results In treated opioids, odds severe form pancreatitis, its complications, death increased. Advanced age associated higher organ/multiple organ failure other...
Abstract Two new neutral ruthenium(II) complexes [Ru( η 6 ‐ p ‐cymene)Cl 2 ( 1 )] 3 ) and 4 =5‐(phenylamino)‐3‐pyrrolidin‐1‐ylisothiazole‐4‐carbonitrile; =3‐morpholin‐4‐yl‐5‐(phenylamino)isothiazole‐4‐carbonitrile) have been synthesized characterized using elemental analysis, IR, UV‐Vis NMR spectroscopy. The crystal structure was confirmed for complex both ligands. Examination of the interactions ligands with CT‐DNA (Calf Thymus DNA), as well HSA (Human Serum Albumin) revealed that could...
The aim of the study was to examine immunomodulatory effect crude Chelidonium majus L ethanolic extract on ex vivo harvested peripheral blood mononuclear cells (PBMNCs). PBMNCs were isolated by density gradient centrifugation. PBMNC cytotoxicity assay performed with HeLa tumor as target cells. MTT used estimate proliferation and cytotoxic efficiency treated PBMNCs. Flow cytometric analysis for immunophenotyping. Treatment induced moderate proliferative response, perturbation in ratios,...
Introduction/Objective. The duration of vaccine-induced protection against SARS-CoV-2 is shown to be limited. aim this study was assess vaccine effectiveness (VE) a third dose four different COVID-19 vaccines during Delta variant predominance in Serbia. Methods. data for the period from August 18, October 1, 2021 were used estimate incidence rates (IR) infection, COVID-19-related hospitalization, and intensive care unit (ICU) admission. included 41,186 fully vaccinated subjects, which 13,589...
Abstract Teucrium polium has been used in traditional medicine around the world for centuries treatment of various conditions and diseases. Many studies have confirmed pharmacological effects its extracts, although immunomodulatory effect not investigated. Therefore, aim our study was to examine methanolic extract T. (TPE) on peripheral blood mononuclear cells (PBMCs) derived from healthy donors patients with hepatitis C virus HCV infection. We analyzed PBMCs viability using MTT test. The...
Background: Infertility is the inability of a sexually active couple, which not using contraception, to achieve pregnancy in one year. Aim: The aim this study was develop and test reliability scale for measuring intensity fear from infertility among students. Material: Creation questionnaire went through several phases: literature review, formation item pool, construction final version questionnaire, testing it on sample statistical analysis. contains 21 questions, with answers form...
Phenolic acids are a large class of compounds occur naturally in variety plants and exhibit wide range biological activities, but toxic effects have also been observed. This study was designed to assess genotoxic effect two selected phenolic acids, gallic ellagic, somatic germ cells Drosophila melanogaster using the sex-linked recessive lethal (SLRL) test comet assay vivo. The obtained results revealed that tested did not induce therefore safety margin for therapeutic use.