A5021221653- Folate and B Vitamins Research
- Cardiac and Coronary Surgery Techniques
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Adipose Tissue and Metabolism
- Fullerene Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Biochemical effects in animals
- Nutrition and Health in Aging
- Chemotherapy-induced cardiotoxicity and mitigation
- Trace Elements in Health
- Natural Antidiabetic Agents Studies
- Aortic Disease and Treatment Approaches
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cell Adhesion Molecules Research
- Vitamin C and Antioxidants Research
- Diet, Metabolism, and Disease
- Angiogenesis and VEGF in Cancer
- Ion Transport and Channel Regulation
- Acute Myocardial Infarction Research
- Congenital gastrointestinal and neural anomalies
University of Belgrade
2015-2024
Oncology Institute of Vojvodina
2024
Institut za onkologiju i radiologiju Srbije
2024
University of Belgrade – Faculty of Medicine
2023
Univerzitetski Klinički Centar Srbije
2014
Institute for Cardiovascular Diseases of Vojvodina
2012
Institut za kardiovaskularne bolesti Dedinje
2009
The aim of our study was to examine the effects different dietary strategies, high-fat (HFd) or standard diet (Sd) alone in combination with standardized oral supplementation (0.45 mL/kg/day) Aronia melanocarpa extract (SAE) rats metabolic syndrome (MetS). SAE is an official product pharmaceutical company Pharmanova (Belgrade, Serbia); however, procedure for extraction done by EU-Chem Serbia). Rats were divided randomly into six groups: control Sd, Sd and SAE, MetS HFd, HFd during 4 weeks....
The aim of this study was to examine the effects folic acid administration on antioxidant enzyme (superoxide dismutase (SOD) and catalase (CAT)) activities, lactate malate dehydrogenase (LDH MDH) certain LDH MDH isoform distribution in cardiac tissue diabetic Wistar male rats. Diabetes mellitus (DM) induced by streptozotocin (STZ). There were five groups: C1-control (physiological saline 1 ml/kg, i.p. one day), C2-control with daily physiological treatment (1 28 days), DM-diabetes (STZ 100...
Osteoarthritis represents a leading cause of disability with limited treatment options. Furthermore, it is frequently accompanied by cardiovascular and cognitive disorders, which can be exacerbated osteoarthritis or drugs used for its treatment. Here, we examined the behavioral cardiac effects novel antidepressant vortioxetine in an model, compared them to duloxetine (an established treatment). was induced male female rats intraarticular sodium-monoiodoacetate injection. Antidepressants were...
We studied the in vivo effects of estradiol on size and biochemical parameters cardiomyocytes pathophysiological conditions such as obesity insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or with high-fat diet (obese, 14). Half obese (obese + estradiol, treated a single dose (40 μg/kg, intraperitoneally) 24 hours after treatment all killed. Estradiol resulted significant increase protein kinase B (Akt) activation ( P < .05) decrease heart mass .05), ratio...
Coronary artery by-pass grafting (CABG) with arterial grafts is widely accepted as the procedure of choice in treatment coronary ischemic disease. It brings back focus on morphological studies arteries used conduits this procedure. One most frequently CABG internal thoracic an excellent graft prognosis and patency rate. The aim study was a detailed morphometric description emphasis its basic histological structure changes aging atherosclerosis. Therefore, 42 full-length were obtained during...
The aim of this study was to investigate the effects aerobic treadmill training regimen four weeks duration on oxidative stress parameters, metabolic enzymes, and histomorphometric changes in colon hyperhomocysteinemic rats. Male Wistar albino rats were divided into groups (n = 10, per group): C, 0.9% NaCl 0.2 mL/day subcutaneous injection (s.c.) 2x/day; H, homocysteine 0.45 µmol/g b.w./day s.c. CPA, saline (0.9% 2x/day) an program; HPA, (0.45 program. HPA group had increased level...
Macrophage inhibitory factor (MIF) is a multipotent cytokine, involved in the inflammatory response to infections or injuries. This study investigates role of MIF liver fibrosis and modulating effect betaine on thioacetamide (TAA)-induced fibrosis. The wild-type knockout MIF−/− C57BL/6 mice were divided into following groups: control; Bet group, which received betaine; MIF−/−; MIF−/−+Bet; TAA TAA; TAA+Bet; MIF−/−+TAA; MIF−/−+TAA+Bet group. After eight weeks treatment, tissue was collected...
Fullerenol (C60(OH)24) is present in aqueous solutions the form of polyanion nanoparticles with particles' size distribution within range from 15 to 42 nm. In this research it assumed that these features could enable fullerenol (FNPs) bind positively charged molecules like doxorubicin (DOX) and serve as drug carriers. Considering this, fullerenol/doxorubicin nanocomposite (FNP/DOX) formed characterized by ultra-performance liquid chromatography tandem mass spectrometry, dynamic light...
Nonalcoholic fatty liver disease (NAFLD) represents a hepatic manifestation of metabolic syndrome. The aim this study was to examine the effect betaine on ultrastructural changes in mouse with methionine- and choline-deficient (MCD) diet-induced NAFLD. Male C57BL/6 mice were divided into groups: Control—fed standard chow, BET—standard chow supplemented (1.5% w/v drinking water), MCD—fed MCD diet, + BET—MCD diet supplementation for 6 weeks. Liver samples taken pathohistology transmission...
Abstract The effects of betaine on hepatocytes chromatin architecture changes were examined by using fractal and gray-level co-occurrence matrix (GLCM) analysis in methionine/choline-deficient (MCD) diet-induced, nonalcoholic fatty liver disease (NAFLD). Male C57BL/6 mice divided into groups: (1) Control: standard diet; (2) BET: diet supplementation through drinking water (solution 1.5%); (3) MCD group: for 6 weeks; (4) MCD+BET: fed with + weeks. Liver tissue was collected histopathology,...
Cardioprotective effects of fullerenol C60(OH)24 nanoparticles (FNP) were investigated in pigs after a single treatment with doxorubicin (DOX). Semithin and ultrathin sections myocardial tissue routinely prepared for transmission electron microscopy analyzed. Extensive intracellular damage was confirmed cardiomyocytes DOX-treated animals. By means ultrastructural analysis, certain degree parenchymal degeneration even animals treated FNP alone, including both the oral intraperitoneal...