A5041949087- Pesticide Exposure and Toxicity
- Paraoxonase enzyme and polymorphisms
- Heavy Metal Exposure and Toxicity
- Cholinesterase and Neurodegenerative Diseases
- Reproductive Physiology in Livestock
- Garlic and Onion Studies
- Ruminant Nutrition and Digestive Physiology
- Protein Structure and Dynamics
- Birth, Development, and Health
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biochemical effects in animals
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Fungal Biology and Applications
- Venomous Animal Envenomation and Studies
- Cynara cardunculus studies
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Nicotinic Acetylcholine Receptors Study
- Exercise and Physiological Responses
- Crystallography and molecular interactions
- Insect and Pesticide Research
- Hydrogen's biological and therapeutic effects
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
University of Belgrade
2015-2024
University of Belgrade – Faculty of Veterinary Medicine
2024
University of Veterinary Medicine
2005-2015
Croatian Veterinary Institute
2011-2015
Centre of Research Excellence in Nutrition and Metabolism
2009-2013
Institute for Technology of Nuclear and other Mineral Raw Materials
2007
Military Medical Academy
2007
Institute for Medical Research
2005
Olive-derived bioactive compound oleuropein was evaluated against damage induced by hydrogen peroxide in human trophoblast cells vitro, examining the changes several markers implicated oxidative stress interactions placenta. Trophoblast HTR-8/SVneo were preincubated with OLE at 10 and 100 µM exposed to H2O2, as a model of stress. Protein lipid peroxidation, well antioxidant enzymes' activity, determined spectrophotometrically, DNA comet assay. iNOS protein expression assessed Western blot,...
In this study we have described the π–π and cation–π interactions between porphyrin ring protein part of porphyrin-containing proteins to better understand their stabilizing role. The number was higher than that in same set studied. pyrrole groups one can be involved with π systems another protein. We found 5.1% Fe2+ metal cations surrounding amino acids as well rings other porphyrins. observed most an energy range −0.5 −2.0 kcal mol−1, while showed −2 −4 mol−1. Further, appreciable...
Chlorpyrifos is a widely used organophosphate pesticide (OP). In birds and mammals OP exhibits toxic effect via inhibition of cholinesterases [acetylcholinesterase (AChE) butyrylcholinesterase (BChE)] through oxidative/nitrosative stress. this study, the influence chlorpyrifos on cholinesterase activity, parameters oxidative stress [malondialdehyde (MDA); glutathione (GSH); superoxide dismutase (SOD); nitrite concentration (NO2-); hydrogen peroxide (H2O2)], inflammatory parameter [activity...
Summary In the present study, we examined effects of fish oil supplementation in 3 months old male Wistar rats on changes plasma and liver lipid metabolism oxidative stress parameters. Twenty were randomly divided into two groups ten animals: control group intervention group, treated for 6 weeks with capsules containing 45 mg eicosapentanoic acid 30 docosahexanoic acid. After intervention, biochemical parameters [triglycerides (TG), low‐density lipoprotein (LDL), high‐density (HDL) total...
Diazinon (DZN) is an organophosphate insecticide which exerts its effect through the inhibition of acetylcholinesterase enzyme (AChE). In this work, we studied development tolerance to subchronic p.o. administration DZN in rats, under both vivo and vitro conditions. A group 20 rats (2 groups, n = 10) was administered 1/10 established LD50 (namely 55.87 mg/kg bw) for 28 days. On 14th 28th day study with isolated diaphragm ileum, examined downregulation nicotinic muscarinic receptor function...
The ability of Agaricus blazei mushroom in its dried and powdered mycelial form was evaluated for antigenotoxic properties the first time. Antigenotoxic effects human peripheral blood cells against H 2 O ‐induced DNA damage were examined pretreatment posttreatment protocol by comet assay. results showed better on interventional level, respectively, after treatment. concentration 250 μ g/mL treatment most efficient regard to action damage. evaluation repair kinetics decrease induced 15 min...
This study is aimed at analysing biochemical and genetic endpoints of toxic effects after administration adrenaline. For this purpose, the was carried out on Wistar rats three doses adrenaline were used: 0.75 mg/kg, 1.5 3 mg/kg body weight. To achieve these aims, we investigated catalase (CAT), Cu, Zn-superoxide dismutase (SOD), malondialdehyde (MDA), nitrite (NO2-), carbonyl groups (PCC), nitrotyrosine (3-NT). Total activity lactate dehydrogenase (LDH), its relative distribution (LDH1-LDH5)...
The effects of co-administration dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters cell damage and inflammation in patients early long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 6 weeks. Patients assigned to groups: phase RA group MTX monotherapy (E MTX), two groups that received co-treatment DOLE MTX: + DOLE) (L-t MTX+ DOLE). Baseline values indicated increased disruption redox balance all groups. After three weeks E maintained high...
Cows in the peripartal period undergo changes thyroid hormones and are susceptible to lipomobilization and/or oxidative stress. The addition of chestnut tannins as polyphenolic compounds diet may improve feed efficiency prevent stress-related health disorders transition cows. However, relationship between tannin supplementation function, which plays an important role metabolic regulation, has not been investigated dairy This study was conducted investigate effects during close-up on status...