A5044327594- Pregnancy and preeclampsia studies
- Nanoparticles: synthesis and applications
- Reproductive System and Pregnancy
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Essential Oils and Antimicrobial Activity
- Birth, Development, and Health
- Phytochemicals and Antioxidant Activities
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Bee Products Chemical Analysis
- Edible Oils Quality and Analysis
- Antioxidant Activity and Oxidative Stress
- Synthesis and Characterization of Heterocyclic Compounds
- Fatty Acid Research and Health
- Proteins in Food Systems
- Galectins and Cancer Biology
- Polysaccharides Composition and Applications
- Free Radicals and Antioxidants
- Garlic and Onion Studies
- Quantum Dots Synthesis And Properties
- Ovarian function and disorders
- Advancements in Transdermal Drug Delivery
- Moringa oleifera research and applications
- Natural product bioactivities and synthesis
University of Belgrade
2017-2025
Institute for the Application of Nuclear Energy
2022-2024
Yellowstone Forever
2021
Institut za filozofiju
2017
Olive-derived bioactive compound oleuropein was evaluated against damage induced by hydrogen peroxide in human trophoblast cells vitro, examining the changes several markers implicated oxidative stress interactions placenta. Trophoblast HTR-8/SVneo were preincubated with OLE at 10 and 100 µM exposed to H2O2, as a model of stress. Protein lipid peroxidation, well antioxidant enzymes' activity, determined spectrophotometrically, DNA comet assay. iNOS protein expression assessed Western blot,...
The biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for the visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) compared pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 or HeLa cells within tested concentration range (1-20 mg/mL), while TiO2/DHQ displayed a significant reduction viability both lines at higher concentrations (≥10...
Fumaria officinalis (fumitory), in the form of dust, was employed as a source bioactive extracts whose chemical profile and biological potential were investigated. According to results optimization extraction protocol, extract with highest polyphenol yield prepared using fumitory dust under optimal conditions determined statistical tool, 23 full factorial design: 50% ethanol 30:1 mL/g ratio during 120 s microwave (22.56 mg gallic acid equivalent/g plant material). LC-MS...
Caffeic acid (CA) has the potential to modulate human extravillous trophoblast cell function. CA stimulated invasion and migration of HTR-8/SVneo cells at least partly through upregulation α1 integrin subunit MMP-2 -9.
Biological activities, including cell viability, oxidative stress, genotoxicity/antigenotoxicity, and antimicrobial activity, were evaluated for a visible-light-responsive TiO2-based ICT complex with dihydroquercetin (DHQ) compared pristine TiO2, its inorganic component. Pristine TiO2 did not induce cytotoxicity in MRC-5 or HeLa cells within the tested concentration range (1-20 mg/mL), while TiO2/DHQ displayed significant reduction viability both lines at higher concentrations (≥10 mg/mL)....
Copper( ii ) complexes with a salicylaldehyde derivative and α-diimines as co-ligands show wide variety of biological activities, such antibacterial, antifungal, antioxidant anticancer activities.
An increase of reactive oxygen species in the placenta and oxidative disbalance has been recognized as a significant factor contributing to pregnancy complications. Dietary intake food rich antioxidants during could exert protective role prevention adverse outcomes such preeclampsia, miscarriage, others. Flavonoid taxifolin shown numerous health-promoting effects large number studies conducted on animals, well various human cell types vitro. However, its placental cells-trophoblasts-have yet...
The aims of the presented study were development four types silibinin-loaded liposomes (multilamellar liposomes-MLVs, sonicated small unilamellar liposomes-SUVs, UV-irradiated liposomes, and lyophilized liposomes) their physicochemical characterization biological potential related to skin health benefits.
Methanolic pulp extracts from the four selected Serbian accessions of Cucurbita maxima were evaluated for phenol profile cytotoxic effects and antimicrobial activity. The results revealed that quinic acid amentoflavone most abundant phenols. increased viability HTR-8 SV/Neo, JEG-3, JAR cells, with pronounced increase in treatment MAX 113 extract. Furthermore, HeLa showed a modest effect. evaluation out pumpkin extracts, 117 could moderately suppress growth Staphylococcus aureus epidermidis...
Successful pregnancy establishment requires highly synchronized cross talk between the invasive trophoblast cells and receptive maternal endometrium. Any disturbances in this tightly regulated process may lead to complications. Local factors such as nutrients, hormones, cytokines reactive oxygen species modulate invasion of extravillous trophoblasts through critical signaling cascades. Epidemiological studies strongly indicate that a Mediterranean diet can significantly impact molecular...
Galectins are a class of lectins that extensively expressed in all organisms. involved range functions, including early development, tissue regeneration, cancer and inflammation. It has been shown galectin-8 is the villous extravillous trophoblast (EVT) cells human placenta; however, its physiological role pregnancy establishment not elucidated. Taking these factors into account, we investigated functional HTR-8/SVneo cells—a EVT cell line—and primary cytotrophoblast isolated from...
Abstract Dry olive leaf extract (DOLE) and its active component oleuropein (OLE) were applied as reducing stabilizing agents to prepare colloidal 20–25 nm silver nanoparticles (Ag NPs). The Ag NPs characterized using transmission electron microscopy, X-ray diffraction analysis, absorption spectroscopy. cytotoxic actions of coated NPs, their inorganic organic components, examined against trophoblast cells human peripheral blood lymphocytes (PBLs), Gram-positive, Gram-negative bacteria, yeast....
The antibacterial performance and cytotoxic examination of in situ prepared silver nanoparticles (Ag NPs), on inorganic-organic hybrid nanopowder consisting zirconium dioxide (ZrO2 NPs) dihydroquercetin (DHQ), was performed against Gram (-) bacteria Escherichia coli (+) Staphylococcus aureus, as well human cervical cancer cells HeLa healthy MRC-5 cells. surface modification ZrO2 NPs, synthesized by the sol-gel method, with DHQ leads to interfacial charge transfer (ICT) complex formation...
Systemic oxidative stress stemming from increased free radical production and reduced antioxidant capacity are common characteristics of obese individuals. Using hydrogen peroxide (H2O2) to induce DNA damage in vitro, peripheral blood mononuclear cells (PBMCs) subjects controls, the protective ability dihidroqercetin (DHQ) biochaga (B) alone or combination, were evaluated. The effects DHQ B estimated under two experimental conditions: pre-treatment, where pre-incubated with substances prior...