A5006089964- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Thermal and Kinetic Analysis
- Crystallography and molecular interactions
- X-ray Diffraction in Crystallography
- Analytical Methods in Pharmaceuticals
- Advanced Drug Delivery Systems
- Electrochemical Analysis and Applications
- Chemical Thermodynamics and Molecular Structure
- Analytical Chemistry and Chromatography
- Polysaccharides Composition and Applications
- Adsorption and biosorption for pollutant removal
- Advanced Photocatalysis Techniques
- Advancements in Transdermal Drug Delivery
- Energetic Materials and Combustion
- thermodynamics and calorimetric analyses
- TiO2 Photocatalysis and Solar Cells
- Conducting polymers and applications
- Material Dynamics and Properties
- Hydrogels: synthesis, properties, applications
- Advanced oxidation water treatment
- 3D Printing in Biomedical Research
- Microencapsulation and Drying Processes
- Catalytic Processes in Materials Science
- Advanced Chemical Sensor Technologies
University of Greenwich
2015-2024
University of Surrey
2024
California Maritime Academy
2023
University of East Anglia
2007
Queen's University Belfast
2004
University of London
2004
Bioadhesive buccal films are innovative dosage forms with the ability to adhere mucosal surface and subsequently hydrate release deliver drugs across membrane. This study aims formulate characterize stable carrageenan (CAR) based desirable drug loading capacity. The were prepared using CAR, poloxamer (POL) 407, various grades of PEG (plasticizer) loaded paracetamol (PM) indomethacin (IND) as model soluble insoluble drugs, respectively. characterized by texture analysis, thermogravimetric...
3D printed LEGO®-like designs are an attractive approach for the development of compartmental delivery systems due to their potential dose personalisation through customisation drug release profiles. Additive manufacturing technologies such as Fused Deposition Modelling (FDM) ideal printing structures with complex geometries and various sizes. This study is a paradigm fabrication LEGO® -like tablets by altering design modular units filament composition different substances. By using...
Polyphenolic compounds are used for treating various diseases due to their antioxidant and anticancer properties. However, utilization of hydrophobic is limited low bioavailability. In order achieve a greater application bioactive compounds, hydrogel beads based on biopolymers can be as carriers enhanced incorporation controlled delivery. this study, the biopolymers-κ-carrageenan, sodium alginate poloxamer 407 were prepared encapsulation curcumin. The characterized using IR, SEM, TGA DSC....
Sirolimus has recently been introduced as a therapeutic agent for breast and prostate cancer. In the current study, conventional Stealth liposomes were used carriers encapsulation of sirolimus. The physicochemical characteristics sirolimus liposome nanoparticles investigated including particle size, zeta potential, stability membrane integrity. addition atomic force microscopy was to study morphology, surface roughness mechanical properties such elastic modulus deformation deformation. in...
Solvent cast films are used as oral strips with potential to adhere the mucosal surface, hydrate and deliver drugs across buccal membrane. The objective of this study was formulation development bioadhesive optimum drug loading for delivery. Films prepared from κ-carrageenan, poloxamer polyethylene glycol or glycerol, were loaded ibuprofen a model water insoluble drug. characterized using texture analysis (TA), hot stage microscopy (HSM), differential scanning calorimetry (DSC),...
Hydrophilic matrices composed of chitosan (CS) and xanthan gum (XG) complexes are pharmaceutical interest in relation to drug delivery due their ability control the release active ingredients. Molecular dynamics simulations (MDs) have been performed order obtain information pertaining effect state protonation degree N-acetylation (DA) on molecular conformation its interact with aqueous solutions. The conformational flexibility CS was found be highly dependent protonation. Upon complexation...
The development and evaluation of a controlled-release (CR) pharmaceutical solid dosage form comprising xanthan gum (XG), low molecular weight chitosan (LCS), metoprolol succinate (MS) are reported. research is, partly, based upon the utilization computational tools: in this case, dynamics simulations (MDs) response surface method (RSM) order to underpin design/prediction minimize experimental work required achieve desired outcomes. capability system control release MS was studied as...
DC Bead is a drug delivery embolisation system that can be loaded with doxorubicin or irinotecan for the treatment of variety liver cancers. In this study we demonstrate topoisomerase I inhibitor topotecan hydrochloride successfully into sulfonate-modified polyvinyl alcohol hydrogel matrix, resulting in sustained-release eluting bead (DEBTOP) useful therapeutic purposes. The vitro loading capacity, elution characteristics and effects on mechanical properties beads are described reference to...
Pollen grains, with their resilient sporopollenin exine and defined morphologies, have been explored as bio-templates for the synthesis of calcium phosphate minerals, particularly hydroxyapatite (HAp) β-tricalcium (TCP). Various pollen morphologies from different plant species (black alder, dandelion, lamb’s quarters, ragweed, stargazer lily) were evaluated. grains underwent acid washing to remove allergenic material facilitate subsequent calcification. Ragweed quarter chosen templates salts...
Films based on carrageenan, alginate and poloxamer 407 have been formulated with the main aim to apply prepared formulations in wound healing process. The films were loaded diclofenac, an anti-inflammatory drug, as well diclofenac curcumin, multipurpose order enhance encapsulation achieve controlled release of these low-bioavailability compounds. obtained data demonstrated improved drug bioavailability (encapsulation efficiency higher than 90%), high, cumulative vitro percentages (90.10% for...
This study is focussed on a comprehensive investigation the state of pollution Danube and Sava rivers in Belgrade region. Different complementary analytical approaches have been used covering both (i) organic ccontaminants river water by target analyses hormones neonicotinoids as well non-target screening (ii) heavy metals sediments. Finally, some common quality parameters analysed. The overall moderate level. Bulk did not reveal any unusual observation. Also quantification preselected...
The photodecolourisation of textile dye Reactive Blue 19 (RB 19), an anionic anthraquinone the reactive class, was investigated using UV radiation in presence H2O2 a batch photo-reactor with low-pressure mercury lamps. effects system parameters: initial pH, concentration, concentration peroxide and intensity, as well salts, (NaCl, Na2SO4, NaNO3, NaH2PO4) on decolourisation examined. Increasing pH resulted increase efficiency. Results showed that from 10 to 100 mg·l–1, efficiency process...
The purpose of this work was to evaluate the possibility creating a ternary co-amorphous system and determine how properties material are altered by addition selected third component. Piroxicam indomethacin form stable with Tg above room temperature. component added based on tendency crystallise (benzamide, caffeine) or amorphous (acetaminophen, clotrimazole) cooling. Generated systems were characterised TGA, HSM, DSC, FTIR XRD. Stable successfully generated, which confirmed using XRD, DSC...
The subject of our research is the optimization direct compression (DC), controlled release drug matrices comprising chitosan/xanthan gum. foregoing considered from two main perspectives; use low molecular weight chitosan (LCS) with xanthan gum (XG) and determination important attributes for mixtures polymers. Powder flow, deformation behaviour, work parameters were used to characterize powder tableting properties. Compression pressure LCS content within matrix investigated their influence...
Dehydrated DLPC, DMPC, DPPC and DSPC have been characterised at temperatures below the diacyl carbon chain-melting transition (T m), using DSC. For first time, existence of pre-Tm processes, which are, usually, only observed in colloidal/liposomal state saturated phospholipids, has detected for dehydrated phosphatidylcholines. Temperature-modulated differential scanning calorimetry was used to characterise several complexes, overlapping pre-T m processes. Kinetic studies m) show activation...