A5046598438- Digital Mental Health Interventions
- Mental Health Research Topics
- Hydrogels: synthesis, properties, applications
- Mental Health Treatment and Access
- Respiratory Support and Mechanisms
- Nanoplatforms for cancer theranostics
- Behavioral Health and Interventions
- Synthesis and properties of polymers
- Aortic Disease and Treatment Approaches
- Cancer, Hypoxia, and Metabolism
- Telemedicine and Telehealth Implementation
- Supramolecular Self-Assembly in Materials
- Infection Control and Ventilation
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Arrest and Resuscitation
- Pancreatic and Hepatic Oncology Research
- Intensive Care Unit Cognitive Disorders
- Innovative Microfluidic and Catalytic Techniques Innovation
- Dendrimers and Hyperbranched Polymers
- Hepatocellular Carcinoma Treatment and Prognosis
- Pituitary Gland Disorders and Treatments
- Biomedical and Engineering Education
- Polymer Surface Interaction Studies
- Cerebrovascular and Carotid Artery Diseases
- Nanoparticle-Based Drug Delivery
King's College London
2021-2024
The London College
2024
University of Otago
2024
University of Bath
2024
University of Oxford
2024
Medway School of Pharmacy
2024
University of Nottingham
2024
University of Brighton
2016-2017
BTG International (United Kingdom)
2017
Biocompatibles (United Kingdom)
2010-2017
DC Bead is a drug delivery embolisation system that can be loaded with doxorubicin or irinotecan for the treatment of variety liver cancers. In this study we demonstrate topoisomerase I inhibitor topotecan hydrochloride successfully into sulfonate-modified polyvinyl alcohol hydrogel matrix, resulting in sustained-release eluting bead (DEBTOP) useful therapeutic purposes. The vitro loading capacity, elution characteristics and effects on mechanical properties beads are described reference to...
<title>Abstract</title> Background The field of digital mental health has followed an exponential growth trajectory in recent years. While the evidence base increased significantly, its adoption within and care services been slowed by several challenges, including a lack knowledge from researchers regarding how to navigate pathway for mandatory regulatory approval. This paper details steps that team must take achieve required approvals carry out research study using novel intervention. We...
To extend the platform of clinically utilised chemoembolic agents based on ion-exchange systems to support delivery anionic drugs, a series PVA-based beads was produced with different levels (3-acrylamidopropyl)trimethylammonium chloride (APTA) in their formulation. The were characterised confirm composition and effect formulation variation physical properties assessed. Suspension polymerisation shown successfully produce uniformly spherical copolymer APTA content up 60 wt%. Equilibrium...
BackgroundThe manufacturing of any standard mechanical ventilator cannot rapidly be upscaled to several thousand units per week, largely due supply chain limitations. The aim this study was design, verify and perform a pre-clinical evaluation based on components not required for ventilators, that met the specifications provided by Medicines Healthcare Products Regulatory Agency (MHRA) rapidly-manufactured systems (RMVS).MethodsThe design utilises closed-loop negative feedback control, with...
Hydrogel microspheres with the capability to interact charged species such as various drugs by ion-exchange processes are useful in a variety of biomedical applications. Such systems have been developed allow active loading microsphere chemotherapeutic agents hospital pharmacy for subsequent locoregional therapy tumours liver drug-eluting bead chemoembolization (DEB-TACE). A microspherical embolisation described, all based upon hydrogels bearing anionic functionalities interaction...
Background. Ultrasound has been explored as an alternative, less bulky, time-consuming and expensive means of intraoperative imaging in pituitary surgery. However, its use limited by the size probes relative to transsphenoidal corridor. We developed a novel prototype that is more slender than previously reported forward-viewing and, this report, we assess feasibility safety initial patient cohort. Method. The probe was integrated into approach patients with adenoma, following single-centre...
Drug release from chemoembolization microspheres stimulated by the presence of a chemically reducing environment may provide benefits for targeting drug resistant and metastatic hypoxic tumours. A water-soluble disulfide-based bifunctional cross-linker bis(acryloyl)-(l)-cystine (BALC) was synthesised, characterised incorporated into modified poly(vinyl) alcohol (PVA) hydrogel beads at varying concentrations using reverse suspension polymerisation. The were to confirm amount within each...
<sec> <title>BACKGROUND</title> Evidence suggests that digital mental health interventions (DMHIs) for common conditions are effective. However, interventions, such as face-to-face therapies, pose risks to patients. A <i>safe</i> intervention is considered one in which the measured benefits outweigh identified and mitigated risks. </sec> <title>OBJECTIVE</title> This study aims review literature assess how DMHIs safety, what reported, they both research postmarket phases building...
The increase in regulatory challenges on medical technology developed and deployed the UK is having a negative impact innovation. In this paper we show how limited capacity of Approved Notified Bodies one more barrier innovation pipeline, that could push teams to consider applying for FDA approval instead UKCA marking, potentially limiting much our patients benefit from world-leading research undertaken universities.