A5087201228- Nanoparticle-Based Drug Delivery
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Spectroscopy and Chemometric Analyses
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Cancer therapeutics and mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Iron oxide chemistry and applications
- Antibiotics Pharmacokinetics and Efficacy
- Bee Products Chemical Analysis
- Characterization and Applications of Magnetic Nanoparticles
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Analytical Chemistry and Chromatography
- Advanced Fluorescence Microscopy Techniques
- Radiopharmaceutical Chemistry and Applications
- Essential Oils and Antimicrobial Activity
- DNA and Nucleic Acid Chemistry
- Synthesis and bioactivity of alkaloids
- Metabolomics and Mass Spectrometry Studies
Université de Tours
2015-2024
Centre National de la Recherche Scientifique
2010-2024
Centre de Biophysique Moléculaire
2022-2024
Nanomed (Brazil)
2014-2023
Pharmac
2016-2019
Institut d'Imagerie Biomédicale
2007-2011
Université d'Orléans
2010
Interfaces, Confinement, Matériaux et Nanostructures
2010
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2010
Laboratoire des Biomolécules
2008-2009
The chemical and structural properties of ferrite-based nanoparticles, precursors for magnetic drug targeting, have been studied by Raman confocal multispectral imaging. nanoparticles were synthesised as aqueous fluids co-precipitation ferrous ferric salts. Dehydrated particles corresponding to (CP) oxidation (OX) steps the fluid preparation compared in order establish oxidation-related features. These are discussed correlation with spectra bulk iron oxides (magnetite, maghemite hematite)...
We report the efficient one-step synthesis and detailed physicochemical evaluation of novel biocompatible nanosystems useful for cancer therapeutics diagnostics (theranostics). These systems are superparamagnetic iron oxide nanoparticles (SPIONs) carrying anticancer drug doxorubicin coated with covalently bonded polymer poly(ethylene glycol) (PEG), native modified biological targeting ligand folic acid (PEG-FA). multifunctional (SPION-DOX-PEG-FA) designed to rationally combine multilevel...
Healthcare-associated infections resulting from bacterial attachment and biofilm formation on medical implants are posing significant challenges in particular with the emergence of resistance to antibiotics. Here, we report design, synthesis characterization self-assembled nanostructures, which integrate their surface antibacterial peptides. The WMR peptide, is a modification native sequence myxinidin, marine peptide isolated epidermal mucus hagfish, was used considering its enhanced...
We report here the development of stable aqueous suspensions biocompatible superparamagnetic iron oxide nanoparticles (SPIONs). These so-called ferrofluids are useful in a large spectrum modern biomedical applications, including novel diagnostic tools and targeted therapeutics. In order to provide prolonged circulation times for vivo, initial were coated with polymer poly(ethylene glycol) (PEG). To permit covalent bonding PEG SPION surface, latter was functionalized coupling agent,...
The present work depicts the efficient one-step synthesis and detailed evaluation of stable aqueous colloids silver nanoparticles (NPs) coated with poly(ethylene glycol) (PEG) covalently attached to their surface. Due steric repulsion between polymer-modified surfaces, stability nanoparticle suspension was preserved even at high ionic strength (0.1 M NaCl). At same time, PEG coating remains sufficiently permeable allow surface-enhanced Raman scattering (SERS) from micromolar concentrations...
Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering molecular finger print of the sample. It expected that its sensitivity would enable detection small chemical variations in biological samples associated with disease. ATR-IR particularly suitable for liquid sample analysis and, although air drying commonly performed before data collection, just drop human serum enough screening early diagnosis. However, dynamic range constituent biochemical...
Vibrational spectroscopic techniques can detect small variations in molecular content, linked with disease, showing promise for screening and early diagnosis. Biological fluids, particularly blood serum, are potentially valuable diagnosis purposes. The so-called Low Molecular Weight Fraction (LMWF) contains the associated peptidome metabolome has been identified as most relevant population disease-associated biomarker research. Although vibrational spectroscopy deliver a specific chemical...
The variable configuration of Raman spectroscopic platforms is one the major obstacles in establishing spectroscopy as a valuable physicochemical method within real-world scenarios such clinical diagnostics. For real world applications like diagnostic classification, models should ideally be usable to predict data from different setups. Whether it done by training rugged model with many setups or primary-replica strategy where are developed on 'primary' setup and test generated 'replicate'...
come from teaching and research institutions in France or abroad, public private centers.L'archive ouverte pluridisciplinaire
This study explores the suitability of Raman spectroscopy as a bioanalytical tool, when coupled with ultra-filtration and multivariate analysis, to detect imbalances in both high molecular weight (total protein content, γ globulins albumin) low (urea glucose) fractions same samples human patient serum, native liquid form. Ultracentrifugation was employed separate concentrate serum. Initially, aqueous solutions respective species, covering physiologically relevant concentration ranges, were...