A5079373121- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Osteoarthritis Treatment and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Mosquito-borne diseases and control
- Nanoparticle-Based Drug Delivery
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Cholinesterase and Neurodegenerative Diseases
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Genetic Neurodegenerative Diseases
- Vitamin D Research Studies
- Cancer Cells and Metastasis
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic function and diabetes
Nantes Université
2017-2021
Zimmer Biomet (France)
2010-2021
Micro et Nanomédecines translationnelles
2010-2021
Université d'Angers
2012-2021
Inserm
2012-2021
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2021
Université Nantes Angers Le Mans
2011-2016
Geriatric Research Education and Clinical Center
2012
Hôpital Saint Eloi
2010
Centre Hospitalier Universitaire d'Angers
1998-2006
Abstract The infusion of BDNF and NT‐3 into Schwann cell (SC) grafts promotes regeneration brainstem neurones the placed in adult rat spinal cord transected at T8 ( Xu et al . 1995b ). Here, we compared normal SCs with genetically modified to secrete human BDNF, grafted as trails 5 mm long distal a transection site also deposited site, for their ability stimulate supraspinal axonal beyond injury. were infected replication‐deficient retroviral vector pL(hBDNF)RNL encoding preproBDNF cDNA....
This study, based on in situ hybridization and immunolabeling experiments, presents the time-course cellular distribution of inducible NO synthase (iNOS) expression a rat model brain inflammation. Both intrahippocampal injection lipopolysaccharide (LPS) or buffer (stab lesion) induce an early, transient, restricted iNOS mRNA immunoreactivity CNS. The topographic phenotypic characteristics iNOS-producing cells are distinct. After stab lesion, mRNAs, expressed at 5 h mainly interventricular...
Zika virus (ZIKV) is a mosquito-borne Flavivirus that causes disease with particular neurological complications, including Guillain-Barré Syndrome and congenital microcephaly. Although ZIKV has been shown to directly infect human neural progenitor cells (hNPCs), thereby decreasing their viability growth, it as yet unknown which of the cellular pathways involved in disruption neurogenesis are affected following infection. By comparing effect two strains vitro on hNPCs, differentiation process...
Abstract In recent years, a neuroimmunomodulatory role for 1,25‐dihydroxyvitamine D 3 [1,25(OH) 2 ] has emerged. Microglial cells present potential target the effects of this hormone in brain. This study focuses on effect 1,25(OH) expression and production inflammatory cytokines nitric oxide (NO) by EOC13 microglial cell line. The presence vitamin D3 receptor microglia was demonstrated RT‐PCR. inhibited tumor necrosis factor‐α, interleukin‐6, NO stimulated concentration‐related fashion....
RationaleEngraftment and survival of transplanted stem or stromal cells in the microenvironment host tissues may be improved by combining such with scaffolds to delay apoptosis enhance regenerative properties. AimsWe examined whether poly(lactic-co-glycolic acid) pharmacologically active microcarriers (PAMs) releasing vascular endothelial growth factor (VEGF) survival, differentiation, angiogenesis adipose tissue-mesenchymal (AT-MSCs).We analysed efficacy AT-MSCs conjugated PAMs a murine...