A5074898722- Bone health and treatments
- Dental Implant Techniques and Outcomes
- Bone and Joint Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- Spectroscopy and Chemometric Analyses
- Bone Metabolism and Diseases
- Forensic Anthropology and Bioarchaeology Studies
- French Urban and Social Studies
- Dental Trauma and Treatments
- Hip disorders and treatments
- Laser Applications in Dentistry and Medicine
- Hematopoietic Stem Cell Transplantation
- Sport and Mega-Event Impacts
- Mesenchymal stem cell research
- Dental materials and restorations
- Forensic Entomology and Diptera Studies
- Parathyroid Disorders and Treatments
- Oral health in cancer treatment
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Orthopaedic implants and arthroplasty
- Anatomy and Medical Technology
Université de Lille
2011-2022
Centre Hospitalier Universitaire de Lille
2007-2022
Adiposité Médullaire et Os
2016-2022
Université du littoral côte d'opale
2008-2022
Centre Oscar Lambret
2020
Unité de Recherche Pluridisciplinaire Sport, Santé, Société
2019
Laboratoire Paul Painlevé
2015-2018
Centre National de la Recherche Scientifique
1998-2017
Cultures et Environnements. Préhistoire, Antiquité, Moyen Âge
2017
New York University
2017
Surface-enhanced Raman scattering (SERS) is a powerful and sensitive technique for the detection of fingerprint signals molecules investigation series surface chemical reactions. Many studies introduced quantitative applications SERS in various fields, several methods have been implemented each specific application, ranging performance characteristics, analytes used, instruments, analytical matrices. In general, very few validated according to international guidelines. As consequence,...
Osteoblasts and adipocytes share a common mesenchymal stem cell origin. Therefore, it has been suggested that the accumulation of marrow observed in bone loss is caused by shift commitment cells from osteogenic pathway to adipogenic pathway. Supporting this hypothesis competition between lineages was widely demonstrated on partially homogeneous populations. However, some data mouse models showed existence an independent relationship mineral content adiposity. combination adipogenesis...
The variable configuration of Raman spectroscopic platforms is one the major obstacles in establishing spectroscopy as a valuable physicochemical method within real-world scenarios such clinical diagnostics. For real world applications like diagnostic classification, models should ideally be usable to predict data from different setups. Whether it done by training rugged model with many setups or primary-replica strategy where are developed on 'primary' setup and test generated 'replicate'...
Acellular extrinsic fiber cementum is a mineralized tissue that covers the cervical half of tooth root surface. It contains mainly or Sharpey's fibers run perpendicular to surface anchor via periodontal ligament. continuously and slowly produced throughout life exhibits an alternating bright dark pattern under light microscopy. However, although better understanding structural background acellular relevant many fields, such as cementochronology, periodontology engineering, remains rarely...
Knowledge of the organization components bone is primary importance in understanding how this tissue responds to stresses and provides a starting point for design development biomaterials. Bone structure has been subject numerous studies. The mineralized fiber arrangement cortical either twisted or orthogonal plywood structure. Both mineral models coexist compact bone. Raman polarized spectroscopy offers definite advantages study biological samples, enabling simultaneous analysis organic...
X-linked hypophosphatemia (XLH) is a skeletal disorder arising from mutations in the PHEX gene, transmitted most cases as an dominant trait. deficiency leads to renal phosphate wasting and hypophosphatemia, well impaired mineralization of bone dentin, resulting severe dental complications. Dentin defects appear characteristic, large interglobular spaces lack fusion calculospherites circumpulpal region during process. Here, we examined changes composition structure dentin using Raman...
Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting young population as peak age diagnosis in 40 s. The natural history non-traumatic ON leads to collapse requiring prosthetic replacement 60% cases. Although trabecular bone involvement suspected, underlying modifications induced at molecular level have not been explored humans. Here, we examine changes composition and structure evaluated by Raman spectroscopy human end-stage ON. Comparing samples from heads...
Bone marrow adipocytes (BMAds) constitute the most abundant stromal component of adult human bone marrow. Two subtypes BMAds have been described, more labile regulated (rBMAds) and stable constitutive (cBMAds), which develop earlier in life are resilient to environmental metabolic disruptions. In vivo, rBMAds enriched saturated fatty acids, contain smaller lipid droplets (LDs) readily provide hematopoietic support than their cBMAd counterparts. Mouse models used for research, but isolation...
X-linked hypophosphatemia (XLH) is a skeletal disease caused by inactivating mutations in the PHEX gene. Mutated or absent protein/enzyme leads to decreased serum phosphate level, which cause mineralization defects skeleton and teeth (osteomalacia/odontomalacia). It not yet altogether clear whether these manifestations are solely insufficient circulating availability for also direct, local intrinsic effect impaired activity. Here, we evaluated role of 3-dimensional model extracellular matrix...
Despite numerous studies of human biominerals, some problems still remain concerning the relationship between their composition and structure. For a better understanding this problem, full spectra internal vibrations tooth enamel crystallites were obtained through polarized Raman microspectrometry these are published for first time. The micro-Raman technique is nondestructive enables micrometric-scale examination all samples with minimum artifacts. show variation from predicted bands many...