A5078062746- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Liver Disease Diagnosis and Treatment
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Hepatitis B Virus Studies
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Protein Kinase Regulation and GTPase Signaling
- Listeria monocytogenes in Food Safety
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Cancer, Hypoxia, and Metabolism
- Pneumonia and Respiratory Infections
- Retinoids in leukemia and cellular processes
- Chemical Synthesis and Analysis
- Tuberculosis Research and Epidemiology
- Essential Oils and Antimicrobial Activity
- Synthesis and Reactivity of Heterocycles
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini"
2020-2025
IRCCS Ospedale San Raffaele
2021
University of Parma
2015-2020
Azienda Ospedaliero Universitaria San Giovanni Battista
1972
We described the molecular characterization of an Enterobacter cloacae strain resistant to cefiderocol, co-harbouring blaIMP-19 and mcr-4.3 resistance genes METHODS: The was isolated from rectal swab a 77-year-old woman during screening for detection patients colonized by carbapenemase-producing Enterobacterales (CPE), in Bologna (Italy). identified at species level MALDI-TOF mass spectrometry presence IMP carbapenemase confirmed both phenotypic immunochromatographic method, rapid commercial...
Between 2021 and 2024, we detected carbapenemase gene bla OXA-181 in 16 of 11,398 Salmonella enterica (SE) isolates: 10 SE 1,4,[5],12:i:-, three Bovismorbificans, two London one Rissen from pigs, humans, pork meat wild roe deer. The was first pig isolates, later suggesting zoonotic transmission. Phylogenetic analysis indicated that horizontal transfer, mainly through plasmids, contributed to the spread. These findings highlight a possible emerging public health threat importance One Health...
The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and reconstruct the origin evolutionary dynamics in Europe between February June 2020. cluster analysis showed only small clusters including < 80 Italian isolates, while most strains intermixed whole tree. Pure observed mainly after lockdown distancing measures adopted. Lineage B B.1 spread late January early 2020, from China Veneto Lombardy, respectively. B.1.1 (20B) probably evolved within central...
Listeria monocytogenes is an ubiquitous pathogen isolated from different host species including fish, crustaceans, and molluscs, but it rarely a pathogenic microorganism to marine reptiles. In particular, only two cases of fatal disseminated listeriosis have been described in the loggerhead sea turtle (Caretta caretta). this study, we describe lethal case L. infection turtle. The was found alive, stranded on beach North-eastern Italy, perished soon after being rescued. autoptic examination...
The population structure of human isolates Listeria monocytogenes in Emilia-Romagna, Italy, from 2012 to 2018 was investigated with the aim evaluating presence genomic clusters indicative possible outbreaks, proportion cluster-associated vs. sporadic and different methods metrics analysis for use routine surveillance. In 2012-2018 period notification rate confirmed invasive cases Emilia-Romagna 0.91 per 100,000 year, more than twice average EU countries. Out total 283 cases, 268 (about 95%)...
The molecular symmetry of multimeric proteins is generally determined by using X-ray diffraction techniques, so that the basic question as to whether this perfectly preserved for same protein in solution remains open. In work, human transthyretin (TTR), a homotetrameric plasma transport with two binding sites thyroid hormone thyroxine (T4), considered case study. Based on crystal structure TTR tetramer, hypothetical D2 inferred solution, whose functional behavior reveals presence markedly...
This case report describes for the first-time cases of severe gastroenteritis in water buffalo calves due to a new serovar Salmonella enterica. The study was carried out on fecal matrix collected from live that showed profuse diarrhea, dehydration and fever, exhibiting systemic course. Culture molecular investigations identified pathogens isolated intestinal contents as two serovars, enterica O:35 isolates multi-drug resistance. Timely diagnosis associated with targeted antimicrobial...
Human salmonellosis is a high-priority foodborne disease worldwide. The main reservoir of
The aim of this study was the reconstruction SARS-CoV-2 evolutionary dynamics in time and space Italy Europe between February June 2020. cluster analysis showed that pure Italian clusters were observed mainly after lockdown distancing measures adopted. Lineage B B.1 spread late January early 2020, from China to Veneto Lombardy, respectively. B.1.1 most probably evolved within central south regions, European countries. lineage B.1.1.1 entered only second half March remained localized Piedmont...
Bovine tuberculosis (bTB) is a chronic inflammatory disease primarily caused by Mycobacterium bovis . The infection affects domestic animals and wildlife, posing zoonotic risk to humans. To understand the dynamics of transmission genetic diversity in Italy’s M. population, we conducted whole-genome sequencing (WGS) analysis on two prevalent genotypes, belonging Spoligotype SB0120, identified different geographical temporal contexts. By comparing these genomes with international isolates,...
A clinical strain of Klebsiella pneumoniae typed as sequence type 307 carrying three different alleles the flu gene encoding Escherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. The are located in chromosome inside putative integrative conjugative elements. displays phenotypes Ag43, i.e. bi-phasic colony morphology enhanced production. Furthermore, produces low amount capsule known to affect Ag43 function. Analysis 1431 worldwide...
This study integrated population data with in vitro assessment of virulence phenotypes to unveil that a considerable part the global Salmonella Derby is evolving enhance its host adaptation swine and this evolution simultaneously increasing attenuation for humans. The shows fixation deleterious mutations SPI-1 has role process. evidence indicates key S. humans but not circulation swine. results show genes generally considered essential pathogenesis do play same all serovars or lineages...
Abstract Background Listeria monocytogenes is a foodborne pathogen with low incidence but severe manifestations in at risk categories (up to 30% fatality rate YOPI). L. can form biofilm and persist food processing environments for decades. In the Lombardy Region up 50% of listeriosis cases have been attributed dairy products. This study aimed investigating clone widely present one most important Italian cheese production chain. Methods Through retrospective analysis PFGE database cluster...
Abstract The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and reconstruct the origin evolutionary dynamics in Europe between February June 2020. cluster analysis showed only small clusters including <80 Italian isolates, while most strains intermixed whole tree. Pure observed mainly after lockdown distancing measures adopted. Lineage B B.1 spread late January early 2020, from China Veneto Lombardy, respectively. B.1.1 probably evolved within...