A5002793023- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Ferrocene Chemistry and Applications
- Radiopharmaceutical Chemistry and Applications
- Synthesis and Biological Evaluation
- Machine Learning in Materials Science
- Organometallic Complex Synthesis and Catalysis
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- Advanced Nanomaterials in Catalysis
- Lanthanide and Transition Metal Complexes
- Cyclopropane Reaction Mechanisms
- Radioactive element chemistry and processing
- Inorganic and Organometallic Chemistry
- Synthesis and biological activity
- Crystallography and molecular interactions
- Magnetism in coordination complexes
- Synthesis and Catalytic Reactions
- Photodynamic Therapy Research Studies
- Asymmetric Hydrogenation and Catalysis
- Synthesis of Tetrazole Derivatives
University of Bern
2022-2024
University of York
2024
University of Zurich
2013-2023
The University of Queensland
2019-2023
King's College London
2022
Imperial College London
2022
St Thomas' Hospital
2022
Research Institute for Bioscience and Biotechnology
2020
University Hospital Regensburg
2014
There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 were evaluated against dangerous ESKAPE pathogens and found have higher hit-rate than organic molecules.
With the widespread rise of antimicrobial resistance, most traditional sources for new drug compounds have been explored intensively classes antibiotics. Meanwhile, metal complexes long had only a niche presence in medicinal chemistry landscape, despite some compounds, such as anticancer cisplatin, having profound impact and still being used extensively cancer treatments today. Indeed, largely ignored antibiotic development. This is surprising access to unique modes action exist wider range...
Two Ru(II) polypyridyl complexes, Ru(DIP)2(bdt) (1) and [Ru(dqpCO2Me)(ptpy)]2+ (2) (DIP = 4,7-diphenyl-1,10-phenanthroline, bdt 1,2-benzenedithiolate, dqpCO2Me 4-methylcarboxy-2,6-di(quinolin-8-yl)pyridine), ptpy 4′-phenyl-2,2′:6′,2″-terpyridine) have been investigated as photosensitizers (PSs) for photodynamic therapy (PDT). In our experimental settings, the phototoxicity phototoxic index (PI) of 2 (IC50(light): 25.3 μM, 420 nm, 6.95 J/cm2; PI >4) particularly 1 0.62 PI: 80) are...
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal strains that resistant to most current antifungals spreading rapidly across the world. To prevent a second resistance crisis, classes of urgently needed. Metal complexes have proven be promising candidates for novel antibiotics, so far, few compounds been explored their potential application as agents. In this work, we report evaluation 1039 metal-containing were screened by Community Open...
To accelerate the discovery of novel metalloantibiotics we applied combinatorial synthesis to preparation 420 manganese tricarbonyl complexes.
Rising antimicrobial resistance (AMR) and lack of innovation in the antibiotic pipeline necessitate novel approaches to discovering new drugs. Metal complexes have proven be promising compounds, but number studied compounds is still low compared millions organic molecules investigated so far. Lately, machine learning (ML) has emerged as a valuable tool for guiding design small molecules, potentially even low-data scenarios. For first time, we extend application ML discovery metal-based...
Abstract Resistance to currently available antifungal drugs has quietly been on the rise but overshadowed by alarming spread of antibacterial resistance. There is a striking lack attention threat drug‐resistant fungal infections, with only handful new in development. Given that metal complexes have proven be useful chemotypes fight against diseases such as cancer, malaria, and bacterial it reasonable explore their possible utility treating infections. Herein we report series cobalt(III)...
Antimicrobial resistance is a looming health crisis, and it becoming increasingly clear that organic chemistry alone not sufficient to continue provide the world with novel effective antibiotics. Recently there has been an increased number of reports describing promising antimicrobial properties metal-containing compounds. Platinum complexes are well known in field inorganic medicinal for their tremendous success as anticancer agents. Here we report on antibacterial platinum cyclooctadiene...
Abstract New antibiotics and innovative approaches to kill drug‐resistant bacteria are urgently needed. Metal complexes offer access alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We developed a light‐activated rhenium complex with activity against S. aureus E. coli . The profile mutant strains combined assessments cellular uptake synergy suggest two distinct action.
Chemotherapy remains one of the dominant treatments to cure cancer. However, due many inherent drawbacks, there is a search for new chemotherapeutic drugs. Many classes compounds have been investigated over years discover targets and synergistic mechanisms action including multicellular targets. In this work, we designed drug candidate against cancer, namely, [Ru(DIP)2(sq)](PF6) (Ru-sq) (DIP = 4,7-diphenyl-1,10-phenanthroline; sq semiquinonate ligand). The aim was combine great potential...
Rhenium-based metallodrugs have recently been highlighted as promising candidates for new antibiotics to combat multi-drug resistant (MDR) pathogens. A class of rhenium(V) dioxo complexes were prepared from readily accessible diphosphine ligands, and shown possess potent activity against Staphylococcus aureus (S. aureus) Candida albicans (C. albicans) alongside low human cell toxicity.
We investigate the ultrafast vibrational dynamics of monolayers from adsorbed rhenium–carbonyl CO2-reduction catalysts on a semiconductor surface (indium–tin-oxide (ITO)) with two-dimensional attenuated total reflection infrared (2D ATR IR) spectroscopy. The complexes are partially equipped isotope-labeled (13C) carbonyl ligands to generate two spectroscopically distinguishable forms molecules. Ultrafast energy transfer between molecules is observed via temporal evolution cross-peaks their...
Multifunctional cyclopentadiene (Cp) ligands and their rhenium 99m Tc complexes were prepared by a versatile synthetic route. The properties of these Cp can be tuned on demand, either during synthesis (variation R1 ) or through post-synthetic functionalization with two equal different vectors (V1 V2 ). Variation groups enables combinatorial approach in the bioorganometallic complexes. This is demonstrated preparation containing both electron-donating electron-withdrawing at position...
Metal complexes have emerged as a promising source for novel classes of antibacterial agents to combat the rise antimicrobial resistance around world. In exploration transition metal chemical space metalloantibiotics, rhenium tricarbonyl moiety has been identified scaffold. Here we prepared eight bisquinoline and explored their properties. Significant activity against both Gram-positive Gram-negative bacteria was observed. However, all also showed significant toxicity human cells, putting...
An improved synthesis of aminoferrocene has been carried out that adheres with the basic green chemistry guidelines. Amination from aqueous NH3 as nitrogen source, inexpensive CuI/Fe2O3 couple cocatalyst in ethanolic solution, makes process environmentally attractive well a viable alternative for all practical purposes. This procedure also applied to prepare aminoruthenocene, being reported first time.
Multifunctional cyclopentadiene ligands are used to prepare difunctional and monofunctional, PSMA-targeting Re(<sc>i</sc>) <sup>99m</sup>Tc(<sc>i</sc>) complexes. The rhenium complex is shown bind the PSMA with an order of magnitude lower <italic>K</italic><sub>D</sub>.
There is a dire need for new classes of antimicrobial compounds to combat the growing threat widespread antibiotic resistance. With currently very scarce drug pipeline, consisting mostly derivatives known antibiotics, antibiotics are urgently required. Antibiotic notorious not having “drug-like” chemical structures. Metal complexes in clinical development treatment cancer, malaria and neurodegenerative diseases. However, only little attention has been paid their application as potential...
Multinuclear complexes or clusters are rarely investigated in medicinal inorganic chemistry although they represent structural intermediates between molecules and nanomaterials. We present this report two strategies towards 99m Tc-containing clusters. In a pre-assembly approach, the preformed but incomplete cluster fragment [Re3 (μ2 -OH)3 (μ3 -OH)(CO)9 ]- reacts with [99m Tc(CO)3 ]+ to highly stable TcRe3 -OH)4 (CO)12 ] cube. The same structure self-assembles when reacting mononuclear Re Tc...
The self-exchange kinetics of CO ligands in the solvated forms commonly used complex [MBr3(CO)3](2-) (M = Re, (99)Tc) were investigated in-depth by (13)C NMR spectroscopy organic solvents such as dimethylformamide and methanol. two homologues exhibit surprisingly different chemical behavior. In case rhenium, stable intermediate [NEt4][ReBr2(CO)4] was isolated characterized IR well single-crystal X-ray diffraction. For technetium, no could be identified. activation parameters (ΔH(⧧) 110 ± 7...
Abstract The formation of di‐ or polynuclear complexes at nanomolar concentrations is generally too slow to be observed with 99m Tc. It reported in this communication that an appropriate choice potentially bridging ligands, herein thiols HS‐R, accelerates the dimerization reaction extent dinuclear are formed very high dilution. nature [ Tc 2 (μ ‐SR) 3 (CO) 6 ] − shown by chromatographic comparison, not only its rhenium homologue as commonly done, but also true 99 analogue.